CYP1A1

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This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
JUMP TOSUBSTRATESINDUCERSINHIBITORS
CYP11A1   *
CYP11B1   *
CYP11B2   *
CYP17A1   *
CYP19A1
CYP1A1
CYP1A2
CYP1B1
CYP21A2
CYP24A1   *
CYP27A1   *
CYP2A1   *
CYP2A6
CYP2B1   *
CYP2B2   *
CYP2B6
CYP2C11   *
CYP2C18   *
CYP2C19
CYP2C8
CYP2C9
CYP2D6
CYP2E1
CYP2J2
CYP2S1
CYP3A11   *
CYP3A2   *
CYP3A4
CYP3A5
CYP3A7
CYP4A1   *
CYP4B1
CYP4F11   *
CYP4F22   *
CYP51A1   *

  * Non-Human
17-beta Estradiol → 2-Hydroxy-Estradiol
Arachidonic acid → 19-hydroxyeicosatetraenoic acid
Cigarette smoke
Docosahexaenoic acid → Epoxydocosapentaenoic acids
Eicosapentaenoic acid → Epoxyeicosatetraenoic acids
Astaxanthin
Black tea   (weak)
Brussel sprouts   (weak)
Curcumin   (weak)
Green tea   (weak)
Multi-vitamin deficiency
Resveratrol
Soybean   (weak)
Acacetin
Black raspberry
Black tea   (weak)
Blueberry
Chrysin   (strong)
Diosmetin
Ellagic acid
Eupatorin
Grape seed extract
Hesperetin
Melatonin   (weak)
Pifithrin alpa   (strong)
Rheum undulatum
Scutellaria baicalensis
Silybum marianum   (strong)
Soybean   (weak)

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