CYP1A2

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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
JUMP TOSUBSTRATESINDUCERSINHIBITORS
CYP11A1   *
CYP11B1   *
CYP11B2   *
CYP17A1   *
CYP19A1
CYP1A1
CYP1A2
CYP1B1
CYP21A2
CYP24A1   *
CYP27A1   *
CYP2A1   *
CYP2A6
CYP2B1   *
CYP2B2   *
CYP2B6
CYP2C11   *
CYP2C18   *
CYP2C19
CYP2C8
CYP2C9
CYP2D6
CYP2E1
CYP2J2
CYP2S1
CYP3A11   *
CYP3A2   *
CYP3A4
CYP3A5
CYP3A7
CYP4A1   *
CYP4B1
CYP4F11   *
CYP4F22   *
CYP51A1   *

  * Non-Human
Acetaminophen
Aflatoxin B1
Amitriptyline
Anthracene
Arachidonic acid → 19-hydroxyeicosatetraenoic acid
Caffeine
Clomipramine
Clozapine
Cyclobenzaprine
Cyclophosphamide
Docosahexaenoic acid → Epoxydocosapentaenoic acids
Duloxetine
Eicosapentaenoic acid → Epoxyeicosatetraenoic acids
Estradiol
Fluvoxamine
Haloperidol
Imipramine
Lidocaine
Melatonin
Mexiletine
Nabumetone
Naproxen
Olanzapine
Ondansetron
Phenacetin
Phenanthrene
Propranolol
Riluzole
Ropivacaine
Tacrine
Theophylline
Tizanidine
Triamterene
Verapamil
Warfarin
Zileuton
Zolmitriptan
Astaxanthin
Beta-naphthoflavone
Black pepper
Black tea
Brussel sprouts
Cabbage
Carbamazepine
Char-grilled meat
Chicory root
Cigarette smoke
Cruciferous vegetables
Green tea
Insulin
Licorice   (weak)
Methylcholanthrene
Modafinil
Multi-vitamin deficiency
Nafcillin
Omeprazole
Resveratrol
Rifampin
Amiodarone
Apiaceous vegetables
Chamomile
Cimetidine   (weak)
Cimicifuga racemosa   (weak)
Ciprofloxacin   (strong)
Clarithromycin
Daidzein
Dandelion
Echinacea purpurea   (strong)
Efavirenz
Erythromycin
Fluoroquinolones
Fluvoxamine
Furafylline
Galangin
Garlic   (weak)
Ginkgo biloba
Grapefruit
Honokiol
Interferon
Isoniazid
Kale
Ketoconazole
Methoxsalen
Mibefradil
Oral contraceptives
Peppermint
Pifithrin alpa   (strong)
Piper methysticum   (strong)
Quercetin
Salvia miltiorrhiza   (strong)
Scutellaria baicalensis
Sulforaphane
Ticlopidine
Turmeric   (weak)

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