CYP1B1

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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.
JUMP TOSUBSTRATESINDUCERSINHIBITORS
CYP11A1   *
CYP11B1   *
CYP11B2   *
CYP17A1   *
CYP19A1
CYP1A1
CYP1A2
CYP1B1
CYP21A2
CYP24A1   *
CYP27A1   *
CYP2A1   *
CYP2A6
CYP2B1   *
CYP2B2   *
CYP2B6
CYP2C11   *
CYP2C18   *
CYP2C19
CYP2C8
CYP2C9
CYP2D6
CYP2E1
CYP2J2
CYP2S1
CYP3A11   *
CYP3A2   *
CYP3A4
CYP3A5
CYP3A7
CYP4A1   *
CYP4B1
CYP4F11   *
CYP4F22   *
CYP51A1   *

  * Non-Human
11-Deoxycorticosterone → Corticosterone
11-Deoxycortisol → Cortisol
17-beta Estradiol → 4-hydroxy Estradiol
18-Hydroxydeoxycorticosterone → 18,19-Dihydroxydeoxycorticosterone
Salvestrol → Cytotoxic metabolite
Cruciferous vegetables
Curcumin
Genistein
Phosphatidylcholine
Polycyclic aromatic hydrocarbons
2,4,3',5'-Tetramethoxystilbene
3,4,5,3',5'-pentamethoxystilbene
3,5,3',5'-tetramethoxystilbene
7-hydrocycymopolone
7-hydroxycymopochromanone
Acacetin
Alizarin
Alpha-naphthoflavone   (strong)
Amentoflavone
Apigenin
Baicalein   (weak)
Chrysin   (strong)
Cirsiliol
Crysoeriol
Desoxyrhapontigenin
Diosmetin
Echinacea purpurea
Eriodictyol
Eupatorin
Genkwanin
Grape seed extract
Hesperetin
Homoeriodictyol
Isoquercetin
Isosakuranetin
Kaempferol
Kaempherol
Luteolin
Melatonin   (weak)
Myricetin
Naringenin
Pinocembrin
Pinostilbene
Pterostilbene
Purpurin
Quercetin
Quercetrin
Rutin
Scutellarein   (weak)
Stilbene
Trans resveratrol

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