CYP2C19

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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
JUMP TOSUBSTRATESINDUCERSINHIBITORS
CYP11A1   *
CYP11B1   *
CYP11B2   *
CYP17A1   *
CYP19A1
CYP1A1
CYP1A2
CYP1B1
CYP21A2
CYP24A1   *
CYP27A1   *
CYP2A1   *
CYP2A6
CYP2B1   *
CYP2B2   *
CYP2B6
CYP2C11   *
CYP2C18   *
CYP2C19
CYP2C8
CYP2C9
CYP2D6
CYP2E1
CYP2J2
CYP2S1
CYP3A11   *
CYP3A2   *
CYP3A4
CYP3A5
CYP3A7
CYP4A1   *
CYP4B1
CYP4F11   *
CYP4F22   *
CYP51A1   *

  * Non-Human
Amitriptyline
Arachidonic acid → Epoxyeicosatetraenoic acids
Bisphenol A
Carisoprodol
Chloramphenicol
Citalopram
Clobazam → Desmethylclobazam
Clomipramine
Clopidogrel
Cyclophosphamide
Diazepam
Docosahexaenoic acid → Epoxydocosapentaenoic acids
Eicosapentaenoic acid → Epoxyeicosatetraenoic acids
Esomeprazole
Formoterol
Hexobarbital
Imipramine
Imipramine N-DeME
Indomethacin
Labetalol
Lansoprazole
Moclobemide
Nelfinavir
Nilutamide
Norphenytoin
Omeprazole
Pantoprazole
Phenobarbitone
Primidone
Progesterone
Proguanil
Propranolol
R-mephobarbital
R-warfarin 8-OH
S-mephenytoin
Teniposide
Voriconazole
Carbamazepine
Efavirenz
Enzalutamide
Hypericum perfoliatum
Norethindrone
Prednisone
Rifampicin
Ritonavir
Garlic   (weak)
Honokiol
Omeprazole   (weak)
Ticlopidine   (weak)

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