CYP2D6

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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
JUMP TOSUBSTRATESINDUCERSINHIBITORS
CYP11A1   *
CYP11B1   *
CYP11B2   *
CYP17A1   *
CYP19A1
CYP1A1
CYP1A2
CYP1B1
CYP21A2
CYP24A1   *
CYP27A1   *
CYP2A1   *
CYP2A6
CYP2B1   *
CYP2B2   *
CYP2B6
CYP2C11   *
CYP2C18   *
CYP2C19
CYP2C8
CYP2C9
CYP2D6
CYP2E1
CYP2J2
CYP2S1
CYP3A11   *
CYP3A2   *
CYP3A4
CYP3A5
CYP3A7
CYP4A1   *
CYP4B1
CYP4F11   *
CYP4F22   *
CYP51A1   *

  * Non-Human
Alprenolol
Amitriptyline
Amphetamine
Aripiprazole
Atenolol
Atomoxetine
Bufuralol
Carvedilol
Chlorpheniramine
Chlorpromazine
Chlorpropamide
Clomipramine
Clonidine
Codeine
Debrisoquine
Desipramine
Dexfenfluramine
Dextromethorphan
Donepezil
Duloxetine
Encainide
Flecainide
Fluoxetine
Fluvoxamine
Haloperidol
Imipramine
Lidocaine
Methoxyamphetamine
Metoclopramide
Mexiletine
Minaprine
Nebivolol
Nortriptyline
Ondansetron
Oxycodone
Paroxetine
Perhexiline
Perphenazine
Phenacetin
Phenformin
Promethazine
Propafenone
Propranolol
Quinidine
Risperidone
Risperidone-OH
S-metoprolol
Sparteine
Tamoxifen
Thioridazine
Timolol
Tramadol
Venlafaxine
Zuclopenthixol
Dexamethasone
Rifampin
Ajmalicine
Amiodarone   (weak)
Berberine
Bupropion   (strong)
Celecoxib
Celery seed
Chinidin
Chlorpheniramine
Chlorpromazine
Cimetidine   (weak)
Cimicifuga racemosa   (weak)
Cinacalcet   (strong)
Citalopram
Clemastine
Clomipramine
Cocaine
Coniine
Coriander
Diphenhydramine
Doxepin
Doxorubicin
Duloxetine   (moderate)
Echinacea purpurea
Ellagic acid
Ergotamine
Escitalopram
Fluoxetin
Fluoxetine   (strong)
Garden cress
Gramine
Halofantrine
Haloperidol
Harmaline
Histamine H1 receptor antagonists
Hydrastic canadensis   (strong)
Hydroxyzine
Kale
Laudanosine
Levomepromazine
Lobelin
Methadone
Metoclopramide
Mibefradil
Midodrine
Moclobemide
Oregano
Paroxetine
Perphenazine
Promethazine
Quinidine
Ranitidine
Reduced-haloperidol
Resveratrol
Ritonavir
Rosemary
Sempervirine
Sertraline   (moderate)
Terbinafine   (moderate)
Ticlopidine
Trifluperidol
Tripelennamine
Vinblastine
Vincamine

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