CYP2E1

CYP2E1 on Wikipedia (opens in tab)
CYP2E1 on PubChem (opens in tab)
List
The CYP2 subfamily is responsible for the majority of P450-mediated drug metabolism in humans. While CYP2E1 itself carries out a relatively low number of these reactions (~4% of known P450-mediated drug oxidations), it and related enzymes CYP1A2 and CYP3A4 are responsible for the breakdown of a large number of toxic environmental chemicals and carcinogens that enter the body, in addition to basic metabolic reactions such as fatty acid oxidations.CYP2E1 metabolizes mostly small, polar molecules, including toxic laboratory chemicals such as dimethylformamide, aniline, and halogenated hydrocarbons . While these oxidations are often of benefit to the body, certain carcinogens and toxins are bioactivated by CYP2E1, implicating the enzyme in the onset of hepatotoxicity caused by certain classes of drugs.
JUMP TOSUBSTRATESINDUCERSINHIBITORS
CYP11A1   *
CYP11B1   *
CYP11B2   *
CYP17A1   *
CYP19A1
CYP1A1
CYP1A2
CYP1B1
CYP21A2
CYP24A1   *
CYP27A1   *
CYP2A1   *
CYP2A6
CYP2B1   *
CYP2B2   *
CYP2B6
CYP2C11   *
CYP2C18   *
CYP2C19
CYP2C8
CYP2C9
CYP2D6
CYP2E1
CYP2J2
CYP2S1
CYP3A11   *
CYP3A2   *
CYP3A4
CYP3A5
CYP3A7
CYP4A1   *
CYP4B1
CYP4F11   *
CYP4F22   *
CYP51A1   *

  * Non-Human
Acetaminophen
Acetone → Propylene glycol + Methylglyoxal
Aniline
Arachidonic acid → 19-hydroxyeicosatetraenoic acid
Benzene
Chlorzoxazone
Docosahexaenoic acid → Epoxydocosapentaenoic acids
Eicosapentaenoic acid → Epoxyeicosatetraenoic acids
Enflurane
Ethanol → Acetaldehyde + Acetate
Evoflurane
Halothane
Isoflurane
Methoxyflurane
N,N-dimethylformamide
Theophylline 8-OH
Broccoli   (weak)
Chicory root
Ethanol
Fish oils   (weak)
Garlic   (moderate)
Ginkgo biloba   (moderate)
Isoniazid
Omega-3 polyunsaturated fatty acids

Black tea
Dandelion
Diethyl-dithiocarbamate
Disulfiram
Garlic
Ginkgo biloba
Green tea
N-acetyl cysteine
Piper methysticum   (strong)
Red wine solids
Resveratrol
Watercress

CYPRESS™ IS A REGISTERED TRADEMARK ® OF DATAPUNK BIOINFORMATICS, LLC. COPYRIGHT © 2015, 2016, 2017 ALL RIGHTS RESERVED.    |    DEVELOPER BLOG     |