CYP3A4

CYP3A4 on Wikipedia (opens in tab)
CYP3A4 on PubChem (opens in tab)
List
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
JUMP TOSUBSTRATESINDUCERSINHIBITORS
CYP11A1   *
CYP11B1   *
CYP11B2   *
CYP17A1   *
CYP19A1
CYP1A1
CYP1A2
CYP1B1
CYP21A2
CYP24A1   *
CYP27A1   *
CYP2A1   *
CYP2A6
CYP2B1   *
CYP2B2   *
CYP2B6
CYP2C11   *
CYP2C18   *
CYP2C19
CYP2C8
CYP2C9
CYP2D6
CYP2E1
CYP2J2
CYP2S1
CYP3A11   *
CYP3A2   *
CYP3A4
CYP3A5
CYP3A7
CYP4A1   *
CYP4B1
CYP4F11   *
CYP4F22   *
CYP51A1   *

  * Non-Human
Alfentanil
Alprazolam
Amlodipine
Androstenedione → 6beta-Hydroxyadrostenedione
Aprepitant
Arachidonic acid → Epoxyeicosatetraenoic acids
Arbamazepine
Aripiprazole
Astemizole
Atorvastatin
Azithromycin
Boceprevir
Buspirone
Cafergot
Caffeine
Cerivastatin
Chlorpheniramine
Cilostazol
Cisapride
Clarithromycin
Clobazam → Desmethylclobazam
Cocaine
Codeine-N-demethylation
Cyclosporine
Dapsone
Dexamethasone
Dextromethorphan
Diazepam
Diltiazem
Docetaxel
Domperidone
Eplerenone
Erythromycin
Estradiol
Felodipine
Fentanyl
Finasteride
Gleevec
Haloperidol
Hydrocortisone
Indinavir
Irinotecan
LAAM
Lercanidipine
Lidocaine
Lovastatin
Methadone
Midazolam
Nateglinide
Nelfinavir
Nevirapine
Nifedipine
Nisoldipine
Nitrendipine
Ondansetron
Pimozide
Progesterone
Propranolol
Quetiapine
Quinidine 3-OH
Quinine
Risperidone
Ritonavir
Romidepsin
Salmeterol
Saquinavir
Sildenafil
Simvastatin
Sirolimus
Sorafenib
Sunitinib
Tacrolimus
Tamoxifen
Taxol
Telaprevir
Telithromycin
Terfenadine
Testosterone → 2beta-Hydroxytestosterone
Torisel
Trazodone
Triazolam
Vemurafenib
Verapamil
Vincristine
Zaleplon
Ziprasidone
Zolpidem
Barbiturates
Carbamazepine
Coleus forskohlii
Curcumin
Echinacea purpurea
Efavirenz
Enzalutamide
Ginger rhizome
Ginkgo biloba
Glucocorticoids
Hypericum perfoliatum
Licorice   (weak)
Modafinil
Nevirapine
Oxcarbazepine
Panax ginseng
Phenobarbital
Phenytoin
Pioglitazone
Rifabutin
Rifampin
Rooibos tea
Salvia miltiorrhiza
Troglitazone
Amiodarone
Aprepitant   (moderate)
Black pepper
Boceprevir
Chloramphenicol
Chrysin
Cimetidine   (weak)
Cimicifuga racemosa   (weak)
Ciprofloxacin
Clarithromycin   (strong)
Cranberry juice
Curcumin
Delaviridine
Diethyl-dithiocarbamate
Diltiazem   (moderate)
Erythromycin   (moderate)
Fluconazole   (moderate)
Fluvoxamine
Garden cress   (weak)
Garlic
Gestodene
Ginkgo biloba   (weak)
Grapefruit juice   (moderate)
Green tea catechin   (weak)
Hydrastic canadensis   (strong)
Imatinib
Indinavir   (strong)
Itraconazole   (strong)
Kale
Ketoconazole   (strong)
Mibefradil
Mifepristone
Myricetin   (weak)
Nefazodone   (strong)
Nelfinavir   (strong)
Norfloxacin
Norfluoxetine
Red wine solids
Resveratrol
Ritonavir   (strong)
Rosemary
Saquinavir   (strong)
Starfruit
Suboxone   (strong)
Telaprevir
Telithromycin   (strong)
Verapamil   (moderate)
Voriconazole
White kidney bean   (strong)

CYPRESS™ IS A REGISTERED TRADEMARK ® OF DATAPUNK BIOINFORMATICS, LLC. COPYRIGHT © 2015, 2016, 2017 ALL RIGHTS RESERVED.    |    DEVELOPER BLOG     |