CYP3A7

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CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults.[3] The gene location is 7q22.1.The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals. Patients with the CYP3A7*1C allele suffer higher rates of cancer progression and mortality, possibly because of worse outcomes among patients treated with chemotherapy drugs that are broken down by the enzyme encoded by CYP3A7.
JUMP TOSUBSTRATESINDUCERSINHIBITORS
CYP11A1   *
CYP11B1   *
CYP11B2   *
CYP17A1   *
CYP19A1
CYP1A1
CYP1A2
CYP1B1
CYP21A2
CYP24A1   *
CYP27A1   *
CYP2A1   *
CYP2A6
CYP2B1   *
CYP2B2   *
CYP2B6
CYP2C11   *
CYP2C18   *
CYP2C19
CYP2C8
CYP2C9
CYP2D6
CYP2E1
CYP2J2
CYP2S1
CYP3A11   *
CYP3A2   *
CYP3A4
CYP3A5
CYP3A7
CYP4A1   *
CYP4B1
CYP4F11   *
CYP4F22   *
CYP51A1   *

  * Non-Human
Alfentanil
Alprazolam
Amlodipine
Aprepitant
Arbamazepine
Aripiprazole
Astemizole
Atorvastatin
Azithromycin
Boceprevir
Buspirone
Cafergot
Caffeine
Cerivastatin
Chlorpheniramine
Cilostazol
Cisapride
Clarithromycin
Cocaine
Codeine-N-demethylation
Cyclosporine
Dapsone
Dexamethasone
Dextromethorphan
Diazepam
Diltiazem
Docetaxel
Domperidone
Eplerenone
Erythromycin
Estradiol
Felodipine
Fentanyl
Finasteride
Gleevec
Haloperidol
Hydrocortisone
Indinavir
Irinotecan
LAAM
Lercanidipine
Lidocaine
Lovastatin
Methadone
Midazolam
Nateglinide
Nelfinavir
Nevirapine
Nifedipine
Nisoldipine
Nitrendipine
Ondansetron
Pimozide
Progesterone
Propranolol
Quetiapine
Quinidine 3-OH
Quinine
Risperidone
Ritonavir
Romidepsin
Salmeterol
Saquinavir
Sildenafil
Simvastatin
Sirolimus
Sorafenib
Sunitinib
Tacrolimus
Tamoxifen
Taxol
Telaprevir
Telithromycin
Terfenadine
Testosterone
Torisel
Trazodone
Triazolam
Vemurafenib
Verapamil
Vincristine
Zaleplon
Ziprasidone
Zolpidem
Barbiturates
Carbamazepine
Efavirenz
Enzalutamide
Glucocorticoids
Hypericum perfoliatum
Modafinil
Nevirapine
Oxcarbazepine
Phenobarbital
Phenytoin
Pioglitazone
Rifabutin
Rifampin
Troglitazone
Amiodarone
Aprepitant   (moderate)
Boceprevir
Celery seed
Chloramphenicol
Cimetidine   (weak)
Ciprofloxacin
Clarithromycin   (strong)
Cumin
Delaviridine
Diethyl-dithiocarbamate
Diltiazem   (moderate)
Erythromycin   (moderate)
Fennel
Fluconazole   (moderate)
Fluvoxamine
Garlic
Gestodene
Grapefruit juice   (moderate)
Imatinib
Indinavir   (strong)
Itraconazole   (strong)
Ketoconazole   (strong)
Mibefradil
Mifepristone
Nefazodone   (strong)
Nelfinavir   (strong)
Norfloxacin
Norfluoxetine
Ritonavir   (strong)
Saquinavir   (strong)
Starfruit
Suboxone   (strong)
Telaprevir
Telithromycin   (strong)
Verapamil   (moderate)
Voriconazole

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