CYP4B1

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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. CYP4B1 shares with other CYP4 proteins a capacity to omega-hydroxylate medium-chain fatty acids, which may be related to an endogenous role for the enzyme. CYP4B1 also participates in the metabolism of certain xenobiotics that are protoxic, including valproic acid, 3-methylindole, 4-ipomeanol, 3-methoxy-4-aminoazobenzene, and numerous aromatic amines. Although these compounds have little in common structurally or chemically, their metabolism by CYP4B1 leads to tissue-specific toxicities in several experimental animals.
JUMP TOSUBSTRATESINDUCERSINHIBITORS
CYP11A1   *
CYP11B1   *
CYP11B2   *
CYP17A1   *
CYP19A1
CYP1A1
CYP1A2
CYP1B1
CYP21A2
CYP24A1   *
CYP27A1   *
CYP2A1   *
CYP2A6
CYP2B1   *
CYP2B2   *
CYP2B6
CYP2C11   *
CYP2C18   *
CYP2C19
CYP2C8
CYP2C9
CYP2D6
CYP2E1
CYP2J2
CYP2S1
CYP3A11   *
CYP3A2   *
CYP3A4
CYP3A5
CYP3A7
CYP4A1   *
CYP4B1
CYP4F11   *
CYP4F22   *
CYP51A1   *

  * Non-Human
3-Methoxy-4-aminoazobenzene
3-Methylindole
4-Ipomeanol
Androstenedione → 6beta-Hydroxyadrostenedione
Estradiol → 2-Hydroxyestradiol
Progesterone → 6beta-Hydroxyprogesterone
Valproic acid
Coffee   (weak)

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