Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs10421768

Hard Link
rs10421768 is a snp on gene HAMP (hepcidin antimicrobial peptide)

GeneHAMP Chromosome number 19 Chromosome position 35281996
Alleles A/G Minor Allele G Minor Allele Frequency 0.1589
Notation -582A>G Clinical significance Orientation (dbSNP) + (positive/forward strand)
SNP Function
Near 5' UTR promoter region 582 bp upstream of the ATG translation initiation codon.
Gene Function
The HAMP gene provides instructions for the production of a protein called hepcidin. Hepcidin was originally identified as having antimicrobial properties, which refers to the ability of this protein to fight bacterial infections. Researchers have discovered that hepcidin plays a major role in maintaining iron balance in the body. They believe that hepcidin circulates in the blood and inhibits iron absorption by the small intestine when the body's supply of iron is too high. Researchers have proposed that hepcidin production in the liver increases when iron enters liver cells from the blood. Hepcidin is then released into the bloodstream and travels throughout the body. This protein interacts primarily with other proteins in the intestines, liver, and certain white blood cells to adjust iron absorption and storage. In this way, iron supplies are monitored and iron absorption is adjusted to reflect the needs of an individual's body. At least eight mutations in the HAMP gene can cause hereditary hemochromatosis. People who have mutations in the HAMP gene are affected by a severe type of juvenile hemochromatosis, sometimes called type 2 hemochromatosis, that begins between the ages of 10 years and 30 years. People with mutations in the HAMP gene are unable to make normal hepcidin and cannot inhibit iron absorption, even when the body has sufficient supplies of iron. The organs of affected people become overloaded with iron, especially the liver and the heart, leading to the organ damage characteristic of this disorder.
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

NOT REPORTED




23andme V5

REPORTED




Ancestry DNA

NOT REPORTED




Genos Export for Promethease

NOT REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





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