Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs1050450

Hard Link
rs1050450 is a snp on gene GPX1 (glutathione peroxidase 1)

GeneGPX1 Chromosome number 3 Chromosome position 49357401
Alleles G/A (transliterated to +) Minor Allele A Minor Allele Frequency 0.2175
Notation P198L Clinical significance Orientation (dbSNP) - (negative/reverse strand)
SNP Function
The main biological role is to protect the organism from oxidative damage. The biochemical function of glutathione peroxidase is to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water. GPX1 is the most abundant version, found in the cytoplasm of nearly all mammalian tissues, whose preferred substrate is hydrogen peroxide.
Gene Function
The GPX1 gene provides instructions for making a member of the glutathione peroxidase family. Glutathione peroxidase helps to detoxify hydrogen peroxide, an oxidizing molecule made in the body, into water, and is one of the most important antioxidant enzymes. This protein along with GPX 2, 3 and 4 are some of only a few proteins known to contain selenocysteine, a form of selenium, and protect cells from oxidative stress. In addition, this protein is characterized by a polyalanine sequence polymorphism which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. 
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

NOT REPORTED




Ancestry DNA

NOT REPORTED




Genos Export for Promethease

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

CURATED




GWAS Curated

NOT CURATED





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