Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs1799836

Hard Link
rs1799836 is a snp on gene MAOB (monoamine oxidase B)

GeneMAOB Chromosome number X Chromosome position 43768752
Alleles T/C (transliterated to +) Minor Allele C Minor Allele Frequency 0.4567
Notation ↓ A118723G Clinical significance Orientation (dbSNP) - (negative/reverse strand)
SNP Function
Intronic.
Gene Function
MAOB is an enzyme located in the outer mitochondrial membrane. It  and plays an important role in the breakdown of neuroactive and vasoactive amines in the central nervous system and peripheral tissues.  Like MAOA, it degrades dopamine. Alzheimer's disease and Parkinson's disease are both associated with elevated levels of MAO-B in the brain.  The normal activity of MAOB creates reactive oxygen species, which directly damage cells. MAOB levels have been found to increase with age, suggesting a role in natural age related cognitive decline and the increased likelihood of developing neurological diseases later in life.  More active polymorphisms of the MAOB gene have been linked to negative emotionality, and suspected as an underlying factor in depression. Activity of MAO-B has also been shown to play a role in stress-induced cardiac damage. The use of MAOB inhibitors to slow natural human aging in otherwise healthy individuals has been proposed, but remains a highly controversial topic. Supplements such as catechin and epicatechin and garlic show some ability to inhibit excess MAOB production. MAOB activity was increased for 60 minutes after exercise.
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

NOT REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





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