Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs1799941

Hard Link
rs1799941 is a snp on gene SHBG (sex hormone-binding globulin)

GeneSHBG Chromosome number 17 Chromosome position 7630105
Alleles A/G Minor Allele A Minor Allele Frequency 0.0988
Notation Clinical significance Orientation (dbSNP) + (positive/forward strand)
SNP Function
[PMID 20841609] high SHBG could reduce risk of type 2 diabetes
Gene Function
SHBG transports androgens (such as testosterone) and estrogens in the blood. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. SHBG is produced mostly by the liver and is released into the bloodstream. SHBG levels are decreased by androgens, administration of anabolic steroids,[20] polycystic ovary syndrome, hypothyroidism, obesity, Cushing's syndrome, and acromegaly. Low SHBG levels increase the probability of Type 2 Diabetes. SHBG levels increase with estrogenic states (oral contraceptives), pregnancy, hyperthyroidism, cirrhosis, anorexia nervosa, and certain drugs. Long-term calorie restriction of more than 50 percent increases SHBG, while lowering free and total testosterone and estradiol.
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

NOT REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





MOST RECENT SEARCHES:
rs13063628 (THRB) | rs225014 (DIO2) | rs12885300 (DIO2-AS1) | rs12095080 (DIO1) | rs1991517 (LOC101928462) | rs2235544 (DIO1) | rs651852 (BHMT) | rs1801131 (MTHFR) | rs1799853 (CYP2C9) | rs1801181 (CBS) | rs1801394 (MTRR)

MOST FREQUENTLY SEARCHED:
rs9939609 (FTO) | rs1799941 (SHBG) | rs1801133 (MTHFR) | rs2569191 (CD14) | rs20541 (IL13) | rs2844682 (MUC21) | rs4680 (COMT) | rs2476601 (PTPN22) | rs6025 (F5) | rs2075252 (LRP2) | rs1801181 (CBS)








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