Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs1799971

Hard Link
rs1799971 is a snp on gene OPRM1 (opioid receptor, mu 1)

GeneOPRM1 Chromosome number 6 Chromosome position 154039662
Alleles A/G Minor Allele G Minor Allele Frequency 0.2234
Notation Clinical significance Orientation (dbSNP) + (positive/forward strand)
Gene Function
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains.
Pharmacogenomics
Morphine (A): Better response to pain relief drugs * Naltrexone (AG): Those with the AG genotype respond better to therapy (increase number of abstinent days)
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

CURATED




GWAS Curated

NOT CURATED





MOST RECENT SEARCHES:
rs1799971 (OPRM1) | rs6003 (F13B) | rs4344931 (AGXT) | rs121912855 (COL7A1) | rs10974944 (JAK2) | rs12272004 (CHR11-LOC116603724) | rs510769 (OPRM1) | rs2296972 (HTR2A-AS1) | rs622337 (HTR2A-AS1) | rs4251417 (SLC6A4) | rs2873804 (DBH)

MOST FREQUENTLY SEARCHED:
rs9939609 (FTO) | rs1801133 (MTHFR) | rs1799941 (SHBG) | rs6025 (F5) | rs4680 (COMT) | rs1801181 (CBS) | rs2569191 (CD14) | rs20541 (IL13) | rs2235544 (DIO1) | rs2075252 (LRP2) | rs2844682 ()








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