Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs1801282

Hard Link
rs1801282 is a snp on gene PPARG (peroxisome proliferator-activated receptor gamma)

GenePPARG Chromosome number 3 Chromosome position 12351626
Alleles C/G Minor Allele G Minor Allele Frequency 0.0703
Notation -2-28078C>G Pro12Ala Clinical significance Orientation (dbSNP) + (positive/forward strand)
SNP Function
ADIPOQ -11391G>A rs17300539 and ADIPOQ -11377C>G rs266729. Reduced transcriptional activity.
Gene Function
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
GWAS Pathologies
Type 2 diabetes (C) ~ Fasting insulin-related traits (interaction with BMI) (?) ~ Type 2 diabetes (C) ~ Type 2 diabetes (C) ~ Type 2 diabetes (C)
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

REPORTED




DSL/ Opus Chip

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

CURATED




GWAS Curated

CURATED





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