Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs1801394

Hard Link
rs1801394 is a snp on gene MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase)

GeneMTRR Chromosome number 5 Chromosome position 7870860
Alleles A/G Minor Allele G Minor Allele Frequency 0.3642
Notation ↓ A66G Ile22Met Clinical significance Orientation (dbSNP) + (positive/forward strand)
SNP Function
Missense mutation
Gene Function
Methionine synthase reductase (MTRR)  is an enzyme that is encoded by the MTRR gene. Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism (methylation of the B-vitamin folate), converting homocysteine into methionine. If MTRR function is compromised due to genetic variation, toxic homocysteine levels can build up because homocysteine is not being converted into methionine. Having the MTRR 66G variant can be a part of this effect. The function of methionine synthase reductase is also inhibited by lead, arsenic, mercury and aluminum toxicity. Medications that deplete vitamin B12 can affect MTRR function. These include: antacids and acid blockers, corticosteroids, metformin, oral contraceptives, gout medications and some cholesterol-lowering drugs.
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

CURATED




GWAS Curated

NOT CURATED





MOST RECENT SEARCHES:
rs13063628 (THRB) | rs225014 (DIO2) | rs12885300 (DIO2-AS1) | rs12095080 (DIO1) | rs1991517 (LOC101928462) | rs2235544 (DIO1) | rs651852 (BHMT) | rs1801131 (MTHFR) | rs1799853 (CYP2C9) | rs1801181 (CBS) | rs1801394 (MTRR)

MOST FREQUENTLY SEARCHED:
rs9939609 (FTO) | rs1799941 (SHBG) | rs1801133 (MTHFR) | rs2569191 (CD14) | rs20541 (IL13) | rs2844682 (MUC21) | rs4680 (COMT) | rs2476601 (PTPN22) | rs6025 (F5) | rs2075252 (LRP2) | rs1801181 (CBS)








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