Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs20541

Hard Link
rs20541 is a snp on gene IL13 (interleukin 13)

GeneIL13 Chromosome number 5 Chromosome position 132660272
Alleles G/A (transliterated to +) Minor Allele A Minor Allele Frequency 0.27
Notation Gln144Arg +2044G/A R130Q Clinical significance Orientation (dbSNP) - (negative/reverse strand)
Gene Function
IL13 is one of a class of immune hormones known as 'cytokines'. IL13 down-regulates the activity of white blood cells known as 'macrophages', and thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. Dietary lectins have been shown to produce immunologic reactions due to their ability to stimulate IL13.
GWAS Pathologies
Self-reported allergy (A) ~ Hodgkin's lymphoma (?) ~ IgE levels (A) ~ Psoriasis (G)
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

CURATED




GWAS Curated

CURATED





MOST RECENT SEARCHES:
rs13063628 (THRB) | rs225014 (DIO2) | rs12885300 (DIO2-AS1) | rs12095080 (DIO1) | rs1991517 (LOC101928462) | rs2235544 (DIO1) | rs651852 (BHMT) | rs1801131 (MTHFR) | rs1799853 (CYP2C9) | rs1801181 (CBS) | rs1801394 (MTRR)

MOST FREQUENTLY SEARCHED:
rs9939609 (FTO) | rs1799941 (SHBG) | rs1801133 (MTHFR) | rs2569191 (CD14) | rs20541 (IL13) | rs2844682 (MUC21) | rs4680 (COMT) | rs2476601 (PTPN22) | rs6025 (F5) | rs2075252 (LRP2) | rs1801181 (CBS)








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