Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs2235544

Hard Link
rs2235544 is a snp on gene DIO1 (deiodinase, iodothyronine, type I)

GeneDIO1 Chromosome number 1 Chromosome position 53909897
Alleles A/C Minor Allele A Minor Allele Frequency 0.4603
Notation 682-34C>A Clinical significance Orientation (dbSNP) + (positive/forward strand)
SNP Function
Intronic variant.
Gene Function
The DIO1 gene provides instructions for making a protein enzyme called propylthiouracil-sensitive oxidoreductase that activates thyroid hormone by converting the hormone thyroxine (T4), produced in the thyroid, to the active bioactive hormone triiodothyronine (T3). It also degrades both hormones. Some versions of this enzyme contain selenocysteine, a compound based on selenium.
GWAS Pathologies
Multiple myeloma (hyperdiploidy) (A) ~ Thyroid hormone levels (A) ~ Thyroid hormone levels (A) ~ Thyroid hormone levels (A)
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

CURATED





MOST RECENT SEARCHES:
rs4880 (SOD2) | rs13063628 (THRB) | rs225014 (DIO2) | rs12885300 (DIO2-AS1) | rs12095080 (DIO1) | rs1991517 (LOC101928462) | rs2235544 (DIO1) | rs651852 (BHMT) | rs1801131 (MTHFR) | rs1799853 (CYP2C9) | rs1801181 (CBS)

MOST FREQUENTLY SEARCHED:
rs9939609 (FTO) | rs1799941 (SHBG) | rs1801133 (MTHFR) | rs2844682 (MUC21) | rs2569191 (CD14) | rs6025 (F5) | rs4680 (COMT) | rs20541 (IL13) | rs1801181 (CBS) | rs2075252 (LRP2) | rs2476601 (PTPN22)








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