Hard Linkrs225014 is a snp on gene
DIO2 (deiodinase, iodothyronine, type II)
Minor Allele Frequency
274A>G T92A D2-Thr92Ala
+ (positive/forward strand)
The DIO2 gene provides instructions for making the type II iodothyronine deiodinase enzyme. This enzyme belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the hormone precursor thyroxine (T4) by removing a molecule of iodine to active triiodothyronine (T3). It is found in the thyroid gland, and may be responsible for the relative increase in production of T3 in the thyroid in patients with Graves disease (an autoimmune disease causing overactitity of the thyroid) and thyroid adenomas (tumors). DIO2 also shows activity in cardiac muscle. This protein contains selenocysteine. DIO2 enzyme has interactions with DIO1, sulfotransferases and glucuronidases in processing, transporting and eliminating hormones and neurotransmitters.