Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs4251417

Hard Link
rs4251417 is a snp on gene SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

GeneSLC6A4 Chromosome number 17 Chromosome position 30224840
Alleles T/C (transliterated to +) Minor Allele T Minor Allele Frequency 0.0278
Notation -220-1925G>A Clinical significance Orientation (dbSNP) - (negative/reverse strand)
SNP Function
Intron variant.
Gene Function
SLC6A4 encodes a protein that terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. The activation region of the SLC6A4 gene contains a polymorphism with "short" and "long" repeats in a region: 5-HTT-linked polymorphic region (5-HTTLPR or SERTPR). The short variation has 14 repeats of a sequence while the long variation has 16 repeats. The short variation leads to less transcription for SLC6A4, and it has been found that it can partly account for anxiety-related personality traits.
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

NOT REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

NOT REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





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