Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs4646437

Hard Link
rs4646437 is a snp on gene CYP3A4 (cytochrome P450, family 3, subfamily A, polypeptide 4)

GeneCYP3A4 Chromosome number Chromosome position
Alleles (transliterated to +) Minor Allele Minor Allele Frequency
Notation 671-205C>T C202T Clinical significance Orientation (dbSNP) - (negative/reverse strand)
SNP Function
Intronic variant.
Gene Function
CYP3A4 is an important enzyme in the body, mainly found in the liver and in the intestine. Its purpose is to oxidize small foreign organic molecules (xenobiotics), such as toxins or drugs, so that they can be removed from the body. While many drugs are deactivated by CYP3A4, there are also some drugs which are activated by the enzyme. Some substances, such as grapefruit juice and some drugs, interfere with the action of CYP3A4. These substances will therefore either amplify or weaken the action of those drugs that are modified by CYP3A4. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. In 1998, various researchers showed that grapefruit juice, and grapefruit in general, is a potent inhibitor of CYP3A4, which can affect the metabolism of a variety of drugs, increasing their bioavailability. In addition to grapefruit, other fruits have similar effects. Noni (M. citrifolia), for example, is a dietary supplement typically consumed as a juice and also inhibits CYP3A4; pomegranate juice has this effect as well. CYP40 family members compete for activity and process hormones and xenobiotics variably in patients. CYP450 family member plays a much greater role in the regulation of oxidative stress due to its redox effects. When upregulated it is a major contributor of ROS and major consumer of reducing agent NADPH, important in glutathione recycling. They also plays a major role in cell danger signaling and cell turnover as it interacts electrically with the apoptosis mechanisms controlled by mitochondria.
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

NOT REPORTED




DSL/ Opus Chip

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





MOST RECENT SEARCHES:
rs36010656 () | rs174556 () | rs9282861 (SULT1A1) | rs1799732 () | i5007206 (MAT1A) | rs2994388 () | rs4933327 () | rs2993763 (MAT1A) | rs7097297 () | rs10509413 () | rs1832683 ()

MOST FREQUENTLY SEARCHED:
rs429358 (APOE) | rs9939609 (FTO) | rs1799941 (SHBG) | rs1801133 (MTHFR) | rs1801181 (CBS) | rs4680 (COMT) | rs6025 (F5) | rs20541 (IL13) | rs2569191 (CD14) | rs2235544 (DIO1) | rs2187668 (HLA-DQA1)








LURP ™ IS A REGISTERED TRADEMARK ® OF DATAPUNK BIOINFORMATICS, LLC. COPYRIGHT © 2015, 2016, 2017, 2018, 2019 ALL RIGHTS RESERVED.    |    DEVELOPER BLOG     |