Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs4880

Hard Link
rs4880 is a snp on gene SOD2 (superoxide dismutase 2, mitochondrial)

GeneSOD2 Chromosome number 6 Chromosome position 159692840
Alleles G/A (transliterated to +) Minor Allele G Minor Allele Frequency 0.4107
Notation ↓ 47T>C Val16Ala A16V Clinical significance Orientation (dbSNP) - (negative/reverse strand)
SNP Function
Missense, 5' UTR variant.
Gene Function
SOD2 is a member of the iron/manganese superoxide dismutase family. SOD2 is one of the body's 'internal' antioxidants. It encodes a  protein that is responsible for oxygen free radical sequestration: SOD2 destroys toxic superoxide anion radicals, the byproducts of oxidative phosphorylation which are normally produced within the mitochondria, binding to them and converting them to hydrogen peroxide and diatomic oxygen. Mutations in the SOD2 gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, microvascular complications of diabetes, and some cancers.   Evidence from invertebrates suggests it may play a role in aging. Overexpression of SOD2 in flies significantly extends their lifespan.
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

CURATED




GWAS Curated

NOT CURATED





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rs3733890 (BHMT) | rs211105 (TPH1) | rs12760457 (PTPN22) | rs75472618 (PLCG2) | rs187956469 (PLCG2) | rs36049418 (SLC12A3) | rs2687116 (CYP3A4) | rs140310 (GSTT1) | rs10857796 (GSTM1) | rs123 (OSBPL3) | rs806368 (CNR1)

MOST FREQUENTLY SEARCHED:
rs1799941 (SHBG) | rs1801133 (MTHFR) | rs9939609 (FTO) | rs1801181 (CBS) | rs6025 (F5) | rs4680 (COMT) | rs2075252 (LRP2) | rs20541 (IL13) | rs2235544 (DIO1) | rs2569191 (CD14) | rs2844682 ()








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