Hard Linkrs4880 is a snp on gene
SOD2 (superoxide dismutase 2, mitochondrial)
G/A (transliterated to +)
Minor Allele Frequency
↓ 47T>C Val16Ala A16V
- (negative/reverse strand)
Missense, 5' UTR variant.
SOD2 is a member of the iron/manganese superoxide dismutase family. SOD2 is one of the body's 'internal' antioxidants. It encodes a protein that is responsible for oxygen free radical sequestration: SOD2 destroys toxic superoxide anion radicals, the byproducts of oxidative phosphorylation which are normally produced within the mitochondria, binding to them and converting them to hydrogen peroxide and diatomic oxygen. Mutations in the SOD2 gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, microvascular complications of diabetes, and some cancers. Evidence from invertebrates suggests it may play a role in aging. Overexpression of SOD2 in flies significantly extends their lifespan.