Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs492602

Hard Link
rs492602 is a snp on gene FUT2 (fucosyltransferase 2 (secretor status included))

GeneFUT2 Chromosome number 19 Chromosome position 48703160
Alleles G/A (transliterated to +) Minor Allele G Minor Allele Frequency 0.3217
Notation 204A>G A68A Clinical significance Orientation (dbSNP) - (negative/reverse strand)
Gene Function
The FUT2 gene provides instructions for making the galactoside 2-L-fucosyltransferase (fucosyltransferase 2) enzyme. This protein is found in the stack of the Golgi apparatus, where proteins made in the cell are folded and glycosylated, having sugars added. The FUT2 enzyme is found in the digestive and respiratory tracts, and is involved in creating a part of the H antigen, which is the blood group antigen for blood type O and the base for building the blood type A and B antigens. Variations in the FUT2 gene determine 'secretor' status, the ability to 'secrete' the ABO blood type antigens into the body fluids (sweat, saliva, digestive mucous, etc.). A functional fucosyltransferase 2 enzyme typically results in the Lewis blood group Lea- Leb+ (secretor). There are many health issues linked to non-secretor status (Lewis blood group Lea+ Leb-), including increased susceptibility to chronic diseases, imbalance of gut bacteria and less functional intestinal membrane, but also immunity from norovirus infection. Lewis double positive is a rare phenotype in Western populations, but more common in Asian populations. Some diseases can cause the Lewis blood group to appear to change. 
GWAS Pathologies
Vitamin B levels in ischemic stroke (C) ~ Cholesterol, total (G) ~ Cholesterol, total (G) ~ Cholesterol, total (G) ~ Vitamin B12 levels (G)
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

CURATED





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