Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs510769

Hard Link
rs510769 is a snp on gene OPRM1 (opioid receptor, mu 1)

GeneOPRM1 Chromosome number 6 Chromosome position 154040884
Alleles T/C (transliterated to +) Minor Allele T Minor Allele Frequency 0.2067
Notation 290+1050C>T Clinical significance Orientation (dbSNP) - (negative/reverse strand)
SNP Function
Intron variant.
Gene Function
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains.
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

NOT REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

NOT REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





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rs769217 (CAT) | rs1599971 (PTPN22) | rs12730735 (PTPN22) | rs2187668 (HLA-DQA1) | rs119461976 (SECISBP2) | rs119461977 (SECISBP2) | rs730880269 (SECISBP2) | rs356219 (LOC105377329) | rs8176719 (ABO) | rs77375493 (JAK2) | rs16942 (BRCA1)

MOST FREQUENTLY SEARCHED:
rs1801133 (MTHFR) | rs9939609 (FTO) | rs1799941 (SHBG) | rs1801181 (CBS) | rs6025 (F5) | rs4680 (COMT) | rs2235544 (DIO1) | rs20541 (IL13) | rs2569191 (CD14) | rs2075252 (LRP2) | rs2844682 ()








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