Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs6323

Hard Link
rs6323 is a snp on gene MAOA (monoamine oxidase A)

GeneMAOA Chromosome number X Chromosome position 43731789
Alleles G/T Minor Allele G Minor Allele Frequency 0.3751
Notation ↓ R297R, G492T, T941G, VNTR Clinical significance Orientation (dbSNP) + (positive/forward strand)
SNP Function
Synonymous variant, TT is normal MAOA activity, G allele is upregulated. VNTR is an indication of the number of repeated DNA segments of that gene that can be methylated during oxidative stress involving gene silencing i.e. down regulating gene expression or deacetylated, upregulating gene expression. [http://dx.doi.org/10.1016/j.ygeno.2013.03.003 PMID: 23517681 DOI: 10.1016/j.ygeno.2013.03.003]
Gene Function
Intolerance to methylfolate supplementation is due to slower breakdown of neurotransmitters including serotonin, dopamine, norepinephrine can lead to low/high levels causing mood swings, OCD, anxiety, aggression, insomnia and depression. Despite feeling depleted patients have a feeling of being overstimulated. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. This enzyme requires B2 (riboflavin) in sufficient levels to function normally. Because this is on the X chromosome, males will have only one allele and is why mutations have an enhanced effect. ACE deletions will also increase anxiety and lower frustration thresholds. 
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

NOT REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

CURATED




GWAS Curated

NOT CURATED





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