Quodlibet Naturopathics

Kaempferol


Kaempferol is a natural flavonol, a type of flavonoid, that has been isolated from tea, broccoli, Delphinium, Witch-hazel, grapefruit, cabbage, kale, beans, endive, leek, tomato, strawberries, grapes, brussels sprouts, apples and other plant sources. Kaempferol is a yellow crystalline solid with a melting point of 276–278 °C. It is slightly soluble in water but soluble in hot ethanol and diethyl ether.

Some epidemiological studies have found a positive association between the consumption of foods containing kaempferol and a reduced risk of developing several disorders such as cancer and cardiovascular diseases. Numerous preclinical studies have shown that kaempferol and some glycosides of kaempferol have a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, neuroprotective, antidiabetic, anti-osteoporotic, estrogenic/antiestrogenic, anxiolytic, analgesic and antiallergic activities (see review article).

Many glycosides of kaempferol, such as kaempferitrin and astragalin, have been isolated as natural products from plants. Kaempferol consumption in tea and broccoli has been associated with reduced risk of heart disease.  A related compound, Naringenin may be present at the same time, such as in grapefruit.

Kaempferol is what gives the flowers of Acacia decurrens and Acacia longifolia their color.  Antidepressant properties have been reported in tests on animals.

An 8-year study found that three flavonols (kaempferol, quercetin, and myricetin) reduced the risk of pancreatic cancer by 23 percent.

Kaempferol consumption appears to reduce lung cancer incidence.

Kaempferol may be a potent prophylactic against NOX-mediated neurodegeneration.





Kaempferol may relate to these other naturopathic agents:

No associations currently defined.
 


Kaempferol is linked to these entities, through the following networks:

CMYC IKK MYC NIK NOS2 TNF


Kaempferol references used by Quodlibet:
  1. Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc.

    Cancer Cell Int    2010 May 11;10:16




KEGG COMPOUND: C05903
Entry
C05903                      Compound                               

Name
Kaempferol;
3,4',5,7-Tetrahydroxyflavone;
3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;
5,7,4'-Trihydroxyflavonol;
C.I. 75640;
Indigo yellow;
Kaempherol;
Kempferol;
Nimbecetin;
Pelargidenolon;
Populnetin;
Rhamnolutein;
Rhamnolutin;
Robigenin;
Swartziol;
Trifolitin
Formula
C15H10O6
Exact mass
286.0477
Mol weight
286.2363
Structure
Mol fileKCF fileDB searchJmolKegDraw
Reaction
Enzyme
1.14.11.23      1.14.13.21      1.14.13.88      2.1.1.76        
2.1.1.155       2.4.1.91        2.4.1.234       2.4.1.-         
2.4.2.56
Brite
Lipids [BR:br08002]
 PK  Polyketides
  PK12 Flavonoids
   PK1211 Flavones and Flavonols
    C05903  Kaempferol
Phytochemical compounds [BR:br08003]
 Flavonoids
  Flavonoids
   Flavonols
    C05903  Kaempferol
Carcinogens [BR:br08008]
 Group 3: Not classifiable as to its carcinogenicity to humans
  Compounds
   C05903  Kaempferol
Major components of natural products [BR:br08323]
 Crude drugs
  Tribulus fruit
   C05903  Kaempferol
BRITE hierarchy
Other DBs
CAS: 
520-18-3
PubChem: 
ChEBI: 
ChEMBL: 
LIPIDMAPS: 
KNApSAcK: 
PDB-CCD: 
3DMET: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C8y C    23.8303  -16.8521
            2   C8y C    23.7662  -15.4486
            3   C8y C    24.9717  -17.5509
            4   C8y C    22.5548  -17.5450
            5   O2x O    24.9834  -14.7497
            6   C8x C    22.5548  -14.7438
            7   C8y C    26.1771  -16.8578
            8   O5x O    24.9658  -18.9544
            9   C8x C    21.3376  -16.8521
            10  O1a O    22.5607  -18.9487
            11  C8y C    26.1830  -15.4603
            12  C8y C    21.3376  -15.4486
            13  O1a O    27.3826  -17.5626
            14  C8y C    27.4702  -14.7614
            15  O1a O    20.1263  -14.7438
            16  C8x C    28.6115  -15.4719
            17  C8x C    27.4059  -13.3637
            18  C8x C    29.8286  -14.7730
            19  C8x C    28.6231  -12.6706
            20  C8y C    29.8346  -13.3753
            21  O1a O    31.0458  -12.6822
BOND        23
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 1
            13   11  14 1
            14   12  15 1
            15   14  16 2
            16   14  17 1
            17   16  18 1
            18   17  19 2
            19   18  20 2
            20   20  21 1
            21    7  11 2
            22    9  12 2
            23   19  20 1

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