Quodlibet Naturopathics

Andrographis paniculata


Since ancient times, A. peniculata is used in traditional Siddha and Ayurvedic[3] systems of medicine as well as in tribal medicine in India and some other countries for multiple clinical applications. The therapeutic value of Kalmegh is due to its mechanism of action which is perhaps by enzyme induction. The plant extract exhibits antityphoid and antifungal activities. Kalmegh is also reported to possess antihepatotoxic, antibiotic, antimalarial, antihepatitic, antithrombogenic, antiinflammatory,[4] anti-snake venom, and antipyretic properties to mention a few, besides its general use as an immunostimulant agent.[5] A study conducted at Bastyr University, showed a significant rise in the mean CD4 lymphocyte level of HIV subjects after administration of 10 mg/kg andrographolide,[6] the chief constituent extracted from the leaves of the plant.

The herb has shown an ability to reduce inflammation (heat) and fight viral infection, and is used as a principal ingredient in traditional Chinese medicinal formulas for lung support from colds. [7]

Andrographolide is a bitter water-soluble lactone exhibiting protective effects in carbon tetrachloride induced hepatotoxicity in rats. Its LD50 in male mice was 11.46 gm/kg, ip. This bitter principle was isolated in pure form by Gorter (1911). Such other activities as liver protection under various experimental conditions of treatment with galactosamine, paracetamol etc. are also attributed to andrographolide. The hepatoprotective action of andrographolide is related to activity of certain metabolic enzymes.[citation needed]

Andrographis paniculata plant extract is known to possess a variety of pharmacological activities. Andrographolide, the major constituent of the extract, is implicated in its pharmacological activity. A study has been conducted on the cellular processes and targets modulated by andrographolide treatment in human cancer and immune cells. Andrographolide treatment inhibited the in vitro proliferation of different tumor cell lines, representing various types of cancers. The compound exerts direct anticancer activity on cancer cells by cell cycle arrest at G0/G1 phase through induction of cell cycle inhibitory protein p27 and decreased expression of cyclin dependent kinase 4 (CDK4)[citation needed]. Immunostimulatory activity of andrographolide is evidenced by increased proliferation of lymphocytes and production of interleukin 2. Andrographolide also enhanced the tumor necrosis factor α production and CD marker expression, resulting in increased cytotoxic activity of lymphocytes against cancer cells, which may contribute for its indirect anticancer activity. The in vivo anticancer activity of the compound is further substantiated against B16F0 melanoma syngenic and HT 29 xenograft models. These results suggest that andrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent.[citation needed]

In one Chilean study, the herb had a significant drying effect on the nasal secretions of cold sufferers who took 1,200 milligrams of andrographis extract daily for five days.[8] A systematic review of the literature and meta-analysis of randomized controlled trials also suggested the herb alone or in combination with eleuthero may be an appropriate alternative treatment of uncomplicated acute upper respiratory tract infection.,[9][10]

The herb is the well-known drug Kalmegh 'green chiretta', and forms the principal ingredient of a household medicine ('alui'), used as a bitter tonic and febrifuge.[citation needed]

The Tamils have been using Nilavempu - as it is called in Tamil - for centuries. In Siddha medicine, Andrographis Paniculata is used widely to treat fevers like chikenguinea, swine-flu, typhoid etc.[11][unreliable source?]

A recent(2011)randomised, double-blind, multicentre,study found Andrographis paniculata as effective as mesalazine (mesalamine) in ulcerative colitis.[12] Further, andrographolide inhibits interleukin-6 expression and suppresses prostate cancer cell growth in vitro.[13]

Andrographis has been shown to be a safe traditional botanical for supporting upper respiratory tract health, per analysis of seven double-blind controlled trials.[14] The herb has been shown to inhibit RANTES secretion in inflamed bronchial cells.[15] RANTES is a chemoattractant for eosinophils, monocytes and lymphocytes that is stored in, and released by, platelets and activated T-cells. In related research: Andrographolide, an active ingredient in Andrographis, has been shown to be responsible for the herb's inflammatory modulating actions, including the reduction of cytokine and peritoneal deposition of neutrophils, and modulation of lung inflammation in vivo.[16] Extracts of Andrographis exhibit potent inflammatory modulating and antioxidant actions in mouse models.[17]

Andrographis paniculata extracts are mosquito repellent and can also be adulticidal to mosquitoes, viz., Culex quinquefasciatus and Aedes aegypti.[18]

[edit] Phytochemistry

Andrographolide is the major constituent extracted from the leaves of the plant which is a bicyclic diterpenoid lactone. This bitter principle was isolated in pure form by Gorter (1911). Such other activities as liver protection under various experimental conditions of treatment with galactosamine (Saraswat et al., 1995), paracetamol (Visen et al., 1993) etc. are also attributed to Andrographolide. The hepatoprotective action of andrographolide is related to the activity of certain metabolic enzymes (Choudhury and Poddar, 1984, 1985; Choudhury et al., 1987). Systematic studies on chemistry of A. paniculata have been carried out.[19]

Some known constituents are:

    14-Deoxy-11-dehydroandrographolide, Plant
    14-Deoxy-11-oxoandrographolide, Plant
    5-Hydroxy-7,8,2',3'-Tetramethoxyflavone, Plant
    5-Hydroxy-7,8,2'-Trimethoxyflavone, Tissue Culture
    Andrographine, Root
    Andrographolide, Plant
    Neoandrographolide, Plant
    Panicoline, Root
    Paniculide-A, Plant
    Paniculide-B, Plant
    Paniculide-C, Plant"[20]

 

  1.  GRIN Species Profile
  2. Sanskrit synonyms of bhunimb Amarkosha ch. 2, section - forest medicinal plants, verse - 143
  3. Medicinal properties of bhunimb Nighatu adarsh
  4. C.V., Thiyagarajan P., Deepak H.B., Agarwal A. , "In vitro modulation of LPS/calcimycin induced inflammatory and allergic mediators by pure compounds of Andrographis paniculata (King of bitters) extract Chandrasekaran" International Immunopharmacology 2011 11:1 (79-84)
  5. Burgos R.A., Hancke J.L., Bertoglio J.C., Aguirre V., Arriagada S., Calvo M., Cáceres D.D. "Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: A prospective randomized placebo-controlled trial" Clinical Rheumatology 2009 28:8 (931-946)
  6. Calabrese, Carlo; Berman, Sheryl H.; Babish, John G.; Ma, Xinfang; Shinto, Lynne; Dorr, Melissa; Wells, Kameron; Wenner, Cynthia A. et al (2000). "A phase I trial of andrographolide in HIV positive patients and normal volunteers". Phytotherapy Research 14 (5): 333–8. doi:10.1002/1099-1573(200008)14:53.0.CO;2-D. PMID 10925397.
  7. Kate Wright (2009). "Natural Anti-Viral Support for Coughs and Congestion" (in English). Nutrition Review 4 (4).
  8. Cáceres, DD; Hancke, JL; Burgos, RA; Sandberg, F; Wikman, GK (1999). "Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study". Phytomedicine 6 (4): 217–23. PMID 10589439.
  9. Poolsup, N.; Suthisisang, C.; Prathanturarug, S.; Asawamekin, A.; Chanchareon, U. (2004). "Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials". Journal of Clinical Pharmacy and Therapeutics 29 (1): 37–45. doi:10.1046/j.1365-2710.2003.00534.x. PMID 14748896.
  10.  Schulz V. "Extract from Andrographis herb for the symptomatic treatment of acute upper respiratory tract infections: Results of a placebo-controlled study in India with 223 patients" Zeitschrift fur Phytotherapie 2010 31:3 (141-142)
  11. "swine flu".
  12. Tang T., Targan S.R., Li Z.-S., Xu C., Byers V.S., Sandborn W.J. ,"Randomised clinical trial: Herbal extract HMPL-004 in active ulcerative colitis - A double-blind comparison with sustained release mesalazine." Alimentary Pharmacology and Therapeutics 2011 33:2 (194-202)
  13. hun JY, Tummala R, Nadiminty N, Lou W, Liu C, Yang J, Evans CP, Zhou Q, Gao AC.,"Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer cell growth.", Genes Cancer. 2010 Aug 1;1(8):868-876 C
  14. Coon JT, Ernst E. Andrographis paniculata: a systematic review of safety and efficacy, Planta, 2004 Apr. Pubmed ID: 15095142.
  15. Ko HC, Wei BL, Chiou WF. The effect of medicinal plants used in Chinese folk medicine on RANTES, Ethnopharmacol, 2006 Mar 17. Pubmed ID: 16621378.
  16. ^ Xia YF, Ye BQ, Li YD, Wang JG, He XY, Lin X, Yao X, Ma D, Slungaard A, Hebbel RP, Key NS, Geng JG. Andrographolide modulates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50, Immunol. 2004 Sep 15. Pubmed ID: 15356172.
  17. Sheeja K, Shihab PK, Kuttan G. Antioxidant and inflammatory modulating activities of the plant Andrographis paniculata Nees, Immunopharmacol Immunotoxicol. 2006. Pubmed ID: 16684672.
  18. Govindarajan M, Sivakumar R. " Adulticidal and repellent properties of indigenous plant extracts against Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae).Parasitol Res. 2011 Oct 20.
  19. Chao W-W., Lin B.-F. "Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian) Chinese Medicine 2010 5 Article Number 17
  20. "Species Information". sun.ars-grin.gov. Retrieved 2008-03-07.



Andrographis paniculata may relate to these other naturopathic agents:


Andrographis paniculata is linked to these entities, through the following networks:

AKT1 CREB1 HIF1A ICAM1 IKBKAP IL1 IL6 NFKB1 NFKB2 P53 PI3K TGFB1 TNF TRAIL UGT1A1 UGT1A10 UGT1A3 UGT1A8 UGT2B15 UGT2B7 VEGFA VEGFB VEGFC


Andrographis paniculata references used by Quodlibet:
  1. Effects of Andrographis paniculata and Orthosiphon stamineus extracts on the glucuronidation of 4-methylumbelliferone in human UGT isoforms.

    Molecules    2010 May 14;15(5):3578-92


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