Copyright © 2011-2012 Peter D'Adamo
  

Multi-map Mashup

Curator(s): Peter D'Adamo

Autophagy - Homo sapiens (human)
NOD-like receptor signaling pathway - Homo sapiens (human)


   

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Multi-map Mashup cluster_node58 AUTOPHAGY INDUCTION cluster_node59 VESICLE NUCLEATION cluster_node60 Anti-viral compound cluster_Bacteria Bacteria cluster_node61 Danger signals cluster_node62 Pore-forming toxin cluster_MAPK MAPK cluster_node63 Inflammasomes 3 cluster_node64 Proinflammatory cytokine processing cluster_node65 Proinflammatory cytokines cluster_Chemokines Chemokines cluster_node66 Inflammasomes 1 cluster_node67 Xenogenous compounds cluster_node68 Inflammasomes 2 cluster_node69 Inflammasomes 4 insulin INS Insulin signaling pathways INS->Insulin signaling pathways node1 11 AMPK AMPK->node1 AMPK mechanistic target of rapamycin (serine/threonine kinase) MTOR AMPK->MTOR ER Stress ER Stress->AMPK Hypoxia Hypoxia->AMPK Amino acid starvation Amino acid starvation->AMPK Rapamycin Rapamycin->AMPK node2 Autophagosome-Lysosyme Fusion node3 18 ATG1 MTOR->ATG1 MTOR->node3 MTOR MTOR signaling pathway MTOR signaling pathway->MTOR node4 1 node5 1 node6 1-phosphatidyl -D-myo -inositol node7 1-phosphatidyl -D-myo -inositol 3-phosphate node6->node7 ATG10 autophagy related 10 homolog (S. cerevisiae) ATG10 node6->ATG10 ATG5 autophagy related 5 homolog (S. cerevisiae) ATG5 ATG10->ATG5 node8 1 ATG16 ATG5->ATG16 ATG5->node8 ATG5 node12 ATG12 -ATG5 -ATG16 Multimeric Complex ATG16->node12 ATG3 autophagy related 3 homolog (S. cerevisiae) ATG3 ATG16->ATG3 ATG7 autophagy related 7 homolog (S. cerevisiae) ATG7 ATG7->ATG10 ATG7->ATG3 ATG7->node2 ATG12 autophagy related 12 homolog (S. cerevisiae) ATG12 ATG12->ATG7 node9 21 B-cell CLL/lymphoma 2 BCL2 BCL2->node9 BCL2 node10 1 BCL2-like 2 BCL2L2 BCL2L2->node10 BCL2L2 golgi-associated PDZ and coiled-coil motif containing GOPC MAPK signaling pathway Insulin signaling pathways->MAPK signaling pathway Insulin signaling pathways->MTOR signaling pathway MAPK signaling pathway->MTOR signaling pathway Apoptosis Antigen presentation Antigen presentation->Apoptosis SNARE complex SNARE complex->Antigen presentation ATG8 ATG4 ATG8->ATG4 ATG4->ATG7 node11 Phospatidylethanolamine (PE) ATG3->node11 ATG3->SNARE complex node13 1 Spermidine Spermidine->MTOR Spermidine->node13 Spermidine Resveratrol Resveratrol ->MTOR node17 1 ROS NALP3 ROS->NALP3 ROS->node17 ROS Anthrax lethal toxin NALP1 Anthrax lethal toxin->NALP1 node20 iE-DAP (γ -D-Glu -mDAP) nucleotide-binding oligomerization domain containing 1 NOD1 node20->NOD1 node21 MDP (Muramyl dipeptide) node21->NALP1 node21->NALP3 nucleotide-binding oligomerization domain containing 2 NOD2 node21->NOD2 SGT1 SGT1->NOD1 node23 3 NOD1->node23 NOD1 RIP2 NOD1->RIP2 thyroid hormone receptor interactor 6 TRIP6 NOD1->TRIP6 TRIP6->RIP2 caspase recruitment domain family,member 6 CARD6 CARD6->RIP2 node24 2 node25 cIAP1/2 node25->RIP2 +u node25->node24 cIAP1/2 caspase recruitment domain family,member 9 CARD9 RIP2->CARD9 caspase 8,apoptosis-related cysteine peptidase CASP8 RIP2->CASP8 node30 MAP3K7 TAB1 TAB2 TAB3 RIP2->node30 TNF receptor-associated factor 6 TRAF6 RIP2->TRAF6 node41 5 CARD9->node41 node26 3 NOD2->node26 NOD2 NOD2->RIP2 Erbin Erbin->NOD2 node27 6 CASP8->Apoptosis CASP8->node27 CASP8 node28 3 node29 IKBKG CHUK IKBKB TRAF6->node29 +u TRAF6->node28 TRAF6 IkB node29->IkB +p node30->node41 +p node30->node29 +p node31 23 node32 11 node33 2 node34 4 IkB->node34 IkB NFkB IkB->NFkB Ubiquitin mediated proteolysis IkB->Ubiquitin mediated proteolysis node35 30 DNA1 NFkB->DNA1 NFkB->node35 NFkB node53 Anti-apoptosis DNA1->node53 node54 Anti-microbial peptides DNA1->node54 Chemokines DNA1->Chemokines Proinflammatory cytokines DNA1->Proinflammatory cytokines DNA 2 DNA 2->Chemokines DNA 2->Proinflammatory cytokines node36 3 node38 21 node39 10 node40 1 Cell death Bacterial RNA Bacterial RNA->NALP3 node43 SGT1 (2) HSP90 node43->HSP90 node43->NALP3 POP ASC 2 POP->ASC 2 Pyrin Pyrin->ASC 2 proline-serine-threonine phosphatase interacting protein 1 PSTPIP1 Pyrin->PSTPIP1 node44 1 node45 1 node46 1 node47 2 HSP90->node47 HSP90 clathrin-ordered protein COP ASC 3 COP->ASC 3 node48 1 node50 1 node51 3 Antimicrobial barrier formation node54->Antimicrobial barrier formation Neutraphil recruitment T cell differentiation Fever T helper cell polarization DC maturation Pyroptosis Antigen specific T and B cell responses node56 Toll -like receptor signaling pathway - Homo sapiens Proinflammatory cytokine proc node56->Proinflammatory cytokine proc Flagellin IPAF Flagellin->IPAF node49 NAIP NLRC4 Flagellin->node49 node16 1 Aerolysin node16->Aerolysin LLO node16->LLO node19 3 Aerolysin->node19 LLO->node19 node18 2 node18->ROS node19->NALP3 NALP3->ASC 2 Cardinal NALP3->Cardinal NALP3->HSP90 node22 4 node22->ROS ERK node41->ERK JNK node41->JNK MAPK Signaling Pathway node41->MAPK Signaling Pathway p38 node41->p38 node42 6 ERK->node42 ERK->node31 ERK JNK->node42 JNK->node32 JNK MAPK Signaling Pathway->node42 p38->node42 p38->node33 p38 node42->DNA 2 node55 7 node55->ROS ASC 1 CASP1 1 ASC 1->CASP1 1 caspase 5,apoptosis-related cysteine peptidase CASP5 ASC 1->CASP5 CASP1 1->node40 CASP1 1 CASP1 1->Cell death CASP1 1->Proinflammatory cytokine proc CASP1 2 ASC 2->CASP1 2 CASP1 2->node44 CASP1 2 CASP1 2->Proinflammatory cytokine proc CASP1 4 ASC 3->CASP1 4 CASP1 4->node48 CASP1 4 CASP1 4->Cell death CASP1 4->Proinflammatory cytokine proc ATG11 ATG1->ATG11 ATG13 autophagy related 13 homolog (S. cerevisiae) ATG13 ATG1->ATG13 ATG17 ATG1->ATG17 ATG6 ATG1->ATG6 VAC8 ATG13->VAC8 ATG14 autophagy related 14 homolog (S. cerevisiae) ATG14 ATG6->ATG14 ATG6->BCL2 ATG6->BCL2L2 ATG6->GOPC VPS34 ATG14->VPS34 VPS34->node6 VPS34->node5 VPS34 Aluminum Aluminum->node55 node15 Amyloid-Beta node15->node18 NALP1->ASC 1 NALP1->CASP5 Asbestos Asbestos->node55 Bacteria Bacteria->node16 Bacteria->Anthrax lethal toxin Bacteria->Bacterial RNA Bacteria->Flagellin Proinflammatory cytokine proc->DC maturation Proinflammatory cytokine proc->Fever Proinflammatory cytokine proc->Pyroptosis Proinflammatory cytokine proc->T helper cell polarization CASP1 3 CASP1 3->node46 CASP1 3 CASP1 5 CASP1 5->node50 CASP1 5 CASP1 5->Cell death CASP1 5->Proinflammatory cytokine proc node14 CPPD (Calcium Pyrophosphade Dihydrate) node14->node18 Cardinal->CASP1 3 Cardinal->node45 Cardinal Chemokines->Antigen specific T and B cell responses Chemokines->Neutraphil recruitment Chemokines->T cell differentiation Proinflammatory cytokines->Antigen specific T and B cell responses Proinflammatory cytokines->Neutraphil recruitment Proinflammatory cytokines->T cell differentiation Extracellular ATP Extracellular ATP->node18 Flagellar Assembly Flagellar Assembly->Flagellin IPAF->ASC 3 node49->CASP1 5 node52 IL-1B node52->node51 IL-1B node37 IL-8 node37->node36 IL-8 interleukin 6 (interferon,beta 2) IL6 IL6->node39 IL6 Peptidoglycan Peptidoglycan->node21 Peptidoglycan->node20 Peptidoglycan synthesis Peptidoglycan synthesis->node21 Peptidoglycan synthesis->node20 R837 R837->node22 R848 R848->node22 Silica Silica->node55 TNFalpha TNFalpha->node38 TNFalpha node57 UV-B node57->node18 Uric acid Uric acid->node18 VPS15 VPS15->node4 VPS15 VPS15->VPS34 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity,alpha) CXCL1 MIP2 chemokine (C-C motif) ligand 2 CCL2 RANTES interleukin 18 (interferon-gamma-inducing factor) IL18