Hedgehog signaling pathway - Homo sapiens (human)

Curator(s): Joe Strothman

The Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and organs. Hh signaling is also involved in control of stem cell proliferation in adult tissues and aberrant activation of the Hh pathway has been linked to multiple types of human cancer. Members of the Hh family bind to patched (ptc), thus releasing smoothened (smo) to transduce a signal. Transcriptional activation occurs through the GLI family of proteins resulting in activation of target genes. | KEGG Map |    

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Hedgehog signaling pathway - Homo sapiens (human) cluster_Membrane Membrane cluster_node9 !grp1 Cholesterol Hh Cholesterol->Hh node1 1 node3 Cos2 STK36 SUFU node1->node3 node2 1 Hh->node2 Hh Ptc Hh->Ptc RAB23,member RAS oncogene family RAB23 RAB23->node1 Ci node3->Ci Zic family member 2 ZIC2 Ci->ZIC2 node4 1 node5 5 Slmb Slmb->Ci Microtubule Microtubule->node3 WNT 1 ZIC2->WNT 1 WNT 2 ZIC2->WNT 2 Dpp ZIC2->Dpp Ptc 2 ZIC2->Ptc 2 node6 2 WNT 1->node6 WNT 1 Wnt signaling pathway WNT 1->Wnt signaling pathway WNT 2->Wnt signaling pathway node7 4 Dpp->node7 Dpp node8 TGF-B signaling pathway Dpp->node8 Ptc 2->node8 growth arrest-specific 1 GAS1 GAS1->Hh glycogen synthase kinase 3 beta GSK3B GSK3B->node5 GSK3B smoothened,frizzled family receptor SMO Ptc->SMO Hip Hip->Hh PKA PKA->Ci +p PKA->node4 PKA SMO->node1 Megalin CK1 print "