NF-kB Signaling Pathway - Homo sapiens (human)

Curator(s): Peter D'Adamo

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls the transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (kappa light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.    

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NF-kB Signaling Pathway - Homo sapiens (human) cluster_node42 CELL MEMBRANE cluster_NUCLEUS NUCLEUS node1 10 node2 1 LPS LPS->node2 LPS toll-like receptor 4 TLR4 LPS->TLR4 node3 2 node4 21 tumor necrosis factor TNF TNF->node4 TNF TNFR TNF->TNFR node5 2 interleukin 1,alpha IL1A IL1A->node5 IL1A IL1R IL1A->IL1R node6 3 node7 IRAK TRAF6 MYD88 node7->node6 IRAK/TRAF6/MYD88 (2) node14 TABs MAP3K7 node7->node14 node16 IKK MAP3K14 MAP3K1 node7->node16 node8 3 node9 TRADD FADD RIP TRAF6 node9->node8 FADD/TRADD/RIP/TRAF6 node9->node16 mitogen-activated protein kinase kinase kinase 3 MAP3K3 node9->MAP3K3 node10 ? node11 ?? node10->node11 node12 11 node13 IKKA IKKB NEMO/IKKG node13->node12 IKKA/IKKB/IKKG-NEMO node31 IKBA NFKB2-p50,52 RELA-p65 node13->node31 NIK node14->NIK node15 7 node16->node13 node16->node15 IKK/MAP3K1/MAP3K14 Growth factors GFR Growth factors->GFR Hormones Hormones->GFR node17 1 node18 1 RAS RAS->node18 RAS node22 PIK3 (2) RAS->node22 Antigen MHC Antigen->MHC breakpoint cluster region BCR Antigen->BCR node19 PIK3 (1) phospholipase C,gamma 2 (phosphatidylinositol-specific) PLCG2 node19->PLCG2 PKCs PLCG2->PKCs node20 4 PKCs->node13 PKCs->node20 PKCs TCR MHC->TCR lymphocyte-specific protein tyrosine kinase LCK LCK->PLCG2 zeta-chain (TCR) associated protein kinase 70kDa ZAP70 ZAP70->PLCG2 MAP3K3->node13 node21 29 AKT AKT->node13 AKT->node21 AKT node22->AKT PKR PKR->node13 CD40L node24 CD40 BR3 LTR CD40L->node24 node23 1 BAFF BAFF->node24 node25 1 NIK->node25 NIK IKKA NIK->IKKA node27 NFKB2-p100 RELB IKKA->node27 node26 22 node27->node26 NFKB2-p100/RELB Proteasomal processing node27->Proteasomal processing node29 NFKB2-p52 RELB Proteasomal processing->node29 node28 22 node30 24 node31->node30 IKBA/RELA-p65/NFKB2-p50,52 node38 NFKB2-p52 RelA-p65 NFKB2-p50 node31->node38 node32 4 UV Irradiation p38 UV Irradiation->p38 node33 2 p38->node33 p38 p38->node38 MSK1 MSK1->node38 node34 5 glycogen synthase kinase 3 beta GSK3B GSK3B->node34 GSK3B GSK3B->node38 node35 2 node36 IKKA/B node36->node35 IKKA/B node40 1 node36->node40 node37 22 node39 2 mucin 1,cell surface associated MUC1 MUC1->node39 MUC1 MUC1->node40 Citation node40->node38 node41 Survival (NFKB) node38->node37 NFKB2-p52/NFKB2-p50/RelA-p65 node38->node41 HDAC node38->HDAC Immune regulation node38->Immune regulation Inflammation node38->Inflammation Proliferation node38->Proliferation node11->node13 ataxia telangiectasia mutated ATM ATM->node13 BCR->node19 BCR->PLCG2 node24->node23 CD40/LT/BR3 node24->NIK GFR->node17 GFR GFR->RAS HDAC->node32 HDAC HDAC->ATM IL1R->node7 TLR4->node1 TLR4 TLR4->node7 TCR->LCK TCR->ZAP70 node29->node28 NFKB2-p52/RELB Lymphopoiesis node29->Lymphopoiesis TNFR->node3 TNFR TNFR->node9 print "