Notch signaling pathway - Homo sapiens (human)

Curator(s): Peter D'Adamo

The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes. | KEGG Map |    

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Notch signaling pathway - Homo sapiens (human) cluster_node10 CO-REPRESSORS cluster_node11 CO-ACTIVATORS node1 2 DVL DVL->node1 DVL Notch DVL->Notch Numb Numb->Notch Delta Delta->Notch MAPK Signaling Notch->MAPK Signaling Ras/ MAPK NICD Notch->NICD Deltex Notch->Deltex Gene Expression MAPK Signaling->Gene Expression node2 3 PSEN PSE2 NCSTN APH S3 Gamma Secretase Complex->Notch S3 Gamma Secretase Complex S3 Gamma Secretase Complex->node2 S3 Gamma Secretase Complex DNA pre T-cell antigen receptor alpha PTCRA DNA->PTCRA node5 Hes 1/5 DNA->node5 node4 RBPJ/CSL NICD->node4 node3 2 node4->DNA node4->node3 RBPJ/CSL SKIP SKIP->node4 node6 1 node7 3 node8 1 node9 2 corepressor interacting with RBPJ,1 CIR1 CIR1->node4 CtBP CtBP->node4 CtBP->node6 CtBP Groucho Groucho->node4 HATS HATS->node4 HATS->node9 HATS HDAC HDAC->node4 HDAC->node7 HDAC Hairless Hairless->node4 MAML MAML->node4 SMRT SMRT->node4 SMRT->node8 SMRT print "