Polyamine synthesis and recycling - Homo sapiens (human)

Curator(s): Peter D'Adamo

Because of the important interactions of polyamines, synthesis and recycling of polyamines are some of the most tightly controlled cellular processes. Polyamine synthesis and recycling. Enzymes are: S-adenosylmethionine decarboxylase (SAMDC), ornithine decarboxylase (ODC), spermidine synthase (SDS), spermine synthase (SMS), spermidine/spermine-N1-acetyltransferase (SAT1), and polyamine oxidase (PAO). Other molecules are: S-adenosylmethionine (SAM), decarboxylated S-adenosylmethionine (dcSAM), and methylthioadenosine (MTA).    

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Polyamine synthesis and recycling - Homo sapiens (human) node1 9 ODC ODC->node1 ODC Putrescine ODC->Putrescine serine dehydratase SDS Spermidine SDS->Spermidine node5 5'-Methylthioadenosine SDS->node5 Autophagy regulation SAM SAMDC SAM->SAMDC dcSAMe SAMDC->dcSAMe spermine synthase SMS Spermine SMS->Spermine SMS->node5 acetylSpermine PAO acetylSpermine->PAO node2 1 spermidine/spermine N1-acetyltransferase 1 SAT1 SAT1->acetylSpermine SAT1->node2 SAT1 acetyl Spermidine SAT1->acetyl Spermidine PAO->Putrescine PAO->Spermidine acetyl Spermidine->PAO Ornithine Ornithine->ODC Putrescine->SDS Urea Cycle Urea Cycle->Ornithine Spermine->SAT1 node3 1 Spermidine->Autophagy regulation Spermidine->SMS Spermidine->SAT1 Spermidine->node3 Spermidine nitric oxide synthase 1 (neuronal) NOS1 Spermidine->NOS1 node4 5 NOS1->node4 NOS1 Methionine dcSAMe->SDS dcSAMe->SMS Adenine node5->Adenine Adenine->Methionine ATP Resveratrol Resveratrol ->Autophagy regulation node6 5 v-myc myelocytomatosis viral oncogene homolog (avian) MYC MYC->node6 MYC adenomatous polyposis coli APC APC->MYC ornithine decarboxylase antizyme 1 OAZ1 APC->OAZ1 OAZ1->ODC print "