Renin-angiotensin system - Homo sapiens (human)

Curator(s): Vanessa Doyle

The renin-angiotensin system (RAS) or the renin-angiotensin-aldosterone system (RAAS) is a hormone system that regulates blood pressure and water (fluid) balance. When blood volume is low, juxtaglomerular cells in the kidneys secrete renin directly into circulation. Plasma renin then carries out the conversion of angiotensinogen released by the liver to angiotensin I. Angiotensin I is subsequently converted to angiotensin II by the enzyme angiotensin converting enzyme found in the lungs. Angiotensin II is a potent vaso-active peptide that causes blood vessels to constrict, resulting in increased blood pressure. Angiotensin II also stimulates the secretion of the hormone aldosterone from the adrenal cortex. Aldosterone causes the tubules of the kidneys to increase the reabsorption of sodium and water into the blood. This increases the volume of fluid in the body, which also increases blood pressure.    
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Renin-angiotensin system - Homo sapiens (human) Angiotensin I carboxypeptidase A3 (mast cell) CPA3 Angiotensin I->CPA3 cathepsin A CTSA Angiotensin I->CTSA angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 ACE2 Angiotensin I->ACE2 membrane metallo-endopeptidase MME Angiotensin I->MME thimet oligopeptidase 1 THOP1 Angiotensin I->THOP1 neurolysin (metallopeptidase M3 family) NLN Angiotensin I->NLN chymase 1,mast cell CMA1 Angiotensin I->CMA1 cathepsin G CTSG Angiotensin I->CTSG node1 Angiotensin (1-9) angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ACE node1->ACE node1->MME node2 Angiotensin (1-7) node2->ACE MAS1 oncogene MAS1 node2->MAS1 node3 Angiotensin (1-5) Angiotensin II Angiotensin II->ACE2 glutamyl aminopeptidase (aminopeptidase A) ENPEP Angiotensin II->ENPEP angiotensin II receptor,type 1 AGTR1 Angiotensin II->AGTR1 angiotensin II receptor,type 2 AGTR2 Angiotensin II->AGTR2 Angiotensin III alanyl (membrane) aminopeptidase ANPEP Angiotensin III->ANPEP Angiotensin III->AGTR1 Angiotensin IV leucyl/cystinyl aminopeptidase LNPEP Angiotensin IV->LNPEP angiotensinogen (serpin peptidase inhibitor,clade A,member 8) AGT renin REN AGT->REN REN->Angiotensin I node7 Kallikrein-kinin system REN->node7 CPA3->node1 CTSA->node1 ACE2->node1 ACE2->node2 node4 1 ACE->node2 ACE->node3 ACE->node4 ACE ACE->node7 MME->node2 node8 Vasodilation, antiproliferative apoptosis MAS1->node8 THOP1->node2 NLN->node2 CMA1->Angiotensin II CTSG->Angiotensin II ENPEP->Angiotensin IV ANPEP->Angiotensin IV node9 Learning and memory, bloodflow, natriuresis LNPEP->node9 node5 2 AGTR1->node5 AGTR1 node6 2 AGTR2->node6 AGTR2 AGTR2->node8 Complement and Coagulation Cascade node7->Complement and Coagulation Cascade print "