Vitamin B6 metabolism - Homo sapiens (human)

Curator(s): Peter D'Adamo

Vitamin B6 is a water-soluble vitamin and is part of the vitamin B complex group. Several forms of the vitamin are known, but pyridoxal phosphate (PLP) is the active form and is a cofactor in many reactions of amino acid metabolism, including transamination, deamination, and decarboxylation. PLP also is necessary for the enzymatic reaction governing the release of glucose from glycogen.Enzymes dependent on PLP focus a wide variety of chemical reactions mainly involving amino acids. The reactions carried out by the PLP-dependent enzymes that act on amino acids include transfer of the amino group, decarboxylation, racemization, and beta- or gamma-elimination or replacement. Such versatility arises from the ability of PLP to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates.    
Zoom out 50% Move left to zoom out, right to zoom in Zoom in 50% 100%

Vitamin B6 metabolism - Homo sapiens (human) Succinate semialdehyde Butanoate metabolism Succinate semialdehyde->Butanoate metabolism node1 node1->Succinate semialdehyde node2 node4 2-Acetamidomethylene succinate node2->node4 Butanoate metabolism->Succinate semialdehyde node3 3-Hydroxy -2-methylpyridine -5-carboxylate node3->node2 node4->node1 node5 node5->node3 node6 3-Hydroxy -2-methylpyridine -4,5-dicarboxylate node6->node5 node7 2-Methyl -3-hydroxy -5-formylpyridine -4-carboxylate node7->node6 node8 4-Pyridoxate node8->node7 Excretion node8->Excretion node9 node9->node8 node10 4-Pyridoxo -lactone node10->node9 node11 node11->node10 Pyridoxal node11->Pyridoxal node12 Pyridoxal->node12 node13 Pyridoxal->node13 node18 Pyridoxal->node18 node12->node8 node13->node8 Pyridoxamine Pyridoxamine->node18 node19 Pyridoxamine->node19 node14 node14->Pyridoxamine node15 node14->node15 node15->Pyridoxal node16 node16->Pyridoxamine node17 node16->node17 node22 Pyridoxamin -5 -phosphate node16->node22 node36 Pyridoxal -5 -phosphate node16->node36 node37 2-Oxoglutarate node16->node37 node38 D-Glutamate node16->node38 Pyruvate node16->Pyruvate node40 D-Alanine node16->node40 node17->Pyridoxal Pyridoxine node17->Pyridoxine node17->node36 node18->node22 node18->node36 node19->Pyridoxal node19->Pyridoxine node19->node22 Pyridoxine->node18 Glycoaldehyde Glycoaldehyde->Pyridoxine Glyoxylate and dicarboxylate metabolism Glyoxylate and dicarboxylate metabolism->Glycoaldehyde node20 node20->Pyridoxal node20->Pyridoxine node21 node21->Pyridoxal node21->Pyridoxine node22->node17 Pentose phosphate pathway node23 D-Erythrose -4-phosphate Pentose phosphate pathway->node23 node42 Ribulose -3 -phosphate Pentose phosphate pathway->node42 node23->Pentose phosphate pathway node24 node24->node23 node25 4-Phospho -D-erythronate node24->node25 node26 node26->node25 node27 2-Oxo -3-hydroxy -4-phosphobutanoate node26->node27 node28 node28->node27 node44 O-phospho -4-hydroxy -threonine node28->node44 node29 node29->Pyridoxine Isopyridoxal node29->Isopyridoxal node30 5-Pyridoxolactone Isopyridoxal->node30 node31 3-Hydroxy -4-hydroxymethyl -2-methylpyridine -5-carboxylate node30->node31 node32 1.14.125.- node31->node32 node33 2-acetamidomethylene -3-hydroxymethyl -3-succinate node32->node33 node34 node33->node34 node35 a-Hydroxymethyl -succinate-semialdehyde node34->node35 node36->node19 Pyridoxine phosphate Pyridoxine phosphate->node17 node39 2 Pyruvate->node39 Pyruvate yaaD yaaD->node36 yaaE yaaE->node36 node41 Glyceraldehyde -3 -phosphate node41->yaaD node41->yaaE Glycolysis Glycolysis->node41 node42->yaaD node42->yaaE node43 4-Hydroxy -L-threonine node43->Pyridoxine node45 node44->node45 node46 node44->node46 node45->node43 node47 (2s) -2 -Amino-3 -oxo-4 -phosphono-butyanoate node46->node47 Spontaneous node47->Spontaneous node48 3-Amino -2-oxopropyl -phosphate Spontaneous->node48 node49 node48->node49 node49->Pyridoxine phosphate print "