Wnt signaling pathway - Homo sapiens (human)

Curator(s): Peter D'Adamo

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.    
Zoom out 50% Move left to zoom out, right to zoom in Zoom in 50% 100%

Wnt signaling pathway - Homo sapiens (human) cluster_EXTRACELLULAR EXTRACELLULAR cluster_node45 !2 cluster_NUCLEUS NUCLEUS cluster_node46 CELL MEMBRANE cluster_SCAFFOLD SCAFFOLD Canonical Pathway cerberus 1,cysteine knot superfamily,homolog (Xenopus laevis) CER1 Canonical Pathway->CER1 DKK Canonical Pathway->DKK FRP Canonical Pathway->FRP porcupine homolog (Drosophila) PORCN Canonical Pathway->PORCN WNT inhibitory factor 1 WIF1 Canonical Pathway->WIF1 node1 2 node2 1 node4 1 node3 Frizzled LRP5/6 Dally node4->node3 node5 1 node6 1 Idax node7 CKI Dvl GBP Idax->node7 node8 1 node9 5 node10 5 node13 3 node15 1 Adherens junction node11 B-catenin APC PP2A Adherens junction->node11 MAPK Signaling Pathway TAK1 MAPK Signaling Pathway->TAK1 JNK MAPK Signaling Pathway->JNK nemo-like kinase NLK TAK1->NLK +p node16 2 node18 3 node16->node18 node17 1 ICAT ICAT->node16 ICAT->node17 ICAT node20 1 node22 5 node24 1 node26 10 node27 2 node29 TGF-B signaling pathway node28 SMAD3 SMAD4 node29->node28 node30 10 p53 p53->node30 p53 node31 Siah-1 SIP SKP1 APC TBL1 p53->node31 p53 signaling pathway p53 signaling pathway->p53 node32 4 node31->node32 Ubiquitin mediated proteolysis node32->Ubiquitin mediated proteolysis +u node33 BTRC SKP1 Cull Rbx1 node33->node32 node34 PAR-1 node35 Dvl (2) node34->node35 node34->node7 Nkd Nkd->node35 Nkd->node7 Daam node35->Daam Rac node35->Rac Planar cell polarity pathway wingless-type MMTV integration site family,member 11 WNT11 Planar cell polarity pathway->WNT11 node36 1 Prickle Prickle->node35 RhoA Daam->RhoA node38 ROCK1/2 RhoA->node38 RhoA->JNK Focal adhesion node38->Focal adhesion Cytoskeletal change Focal adhesion->Cytoskeletal change Rac->JNK node39 11 JNK->node39 JNK Gene expression JNK->Gene expression node40 Wnt/Ca2+ pathway WNT5 node40->WNT5 node41 1 PLC node42 Ca2+ PLC->node42 PKC PLC->PKC CaMKII node42->CaMKII node42->PKC CaN node42->CaN node43 5 PKC->node43 PKC NFAT CaN->NFAT -p node44 2 node3->node2 Frizzled~LRP5/6~Dally node3->node7 node19 TCF/LEF node18->node19 node12 node12->node11 node11->node10 B-catenin~APC~PP2A node11->Adherens junction node11->node16 node11->node32 node21 DNA (1) node19->node21 Axam Axam->node7 glycogen synthase kinase 3 beta GSK3B node7->GSK3B Wnt CER1->Wnt Wnt->node1 Wnt Wnt->node4 CK2 CK2->node8 CK2 GSK3B->node9 GSK3B GSK3B->node11 +p NFAT->node44 NFAT NFAT->node21 DKK->node6 DKK DKK->node3 FRP->node4 FRP->node5 FRP PORCN->Wnt WIF1->Wnt CtBP CtBP->node20 CtBP CtBP->node19 FOS-like antigen 1 FOSL1 node21->FOSL1 matrix metallopeptidase 7 (matrilysin,uterine) MMP7 node21->MMP7 peroxisome proliferator-activated receptor delta PPARD node21->PPARD node25 c-JUN node21->node25 node23 c-MYC node21->node23 cycD node21->cycD Cell cycle FOSL1->Cell cycle MMP7->Cell cycle PPARD->Cell cycle node25->node24 c-JUN node25->Cell cycle node23->node22 c-MYC node23->Cell cycle cycD->node26 cycD cycD->Cell cycle Duplin Duplin->node18 Frizzled Frizzled->node41 Frizzled Frizzled->PLC node37 Frizzled Sfbm Knypek node37->node35 node37->node36 Frizzled~Sfbm~Knypek Groucho Groucho->node19 NLK->node19 PKA PKA->node15 PKA node14 PS-1 node14->node13 PS-1 node14->node11 node14->PKA WNT11->node37 Pontin52 Pontin52->node18 node28->node27 SMAD3~SMAD4 node28->node18 WNT5->Frizzled Xsox17 Xsox17->node18 Alzheimers disease AXIN print "