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Collinsella

RANK: Genus

TAXONOMY: Bacteria -> Terrabacteria group -> Actinobacteria -> Coriobacteriia -> Coriobacteriales -> Coriobacteriaceae -> Collinsella

OVERVIEW:

'Collinsella' is a genus of Actinobacteria, in the family Coriobacteriaceae. Gram-stain-positive, obligatory anaerobic organism which forms chains of rods (0.3–0.7 × 1.2–4.3 µm). Does not form spores or flagella. Colonies are produced in 2 d at 37°C on EG agar in an anaerobic jar containing 100% CO2. Fermentation products of glucose are ethanol, formate, hydrogen, and lactate. Cell wall contains an A4 type peptidoglycan. The 16S rDNA sequence analysis shows that the organism is a member of the family Coriobacteriaceae, which also includes the genera Atopobium, Coriobacterium, Cryptobacterium, Denitrobacterium, Eggerthella, Olsenella, and Slackia.

DNA G+C content (mol%): 60–65 (HPLC).

Type species: Collinsella aerofaciens

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072]

Association with rheumatoid arthritis: Collinsella genus correlated strongly with high levels of three metabolites (beta-alanine, alpha-aminoadipic acid, and asparagine). The role of the RA-associated bacteria Collinsella was confirmed using a human epithelial cell line and a humanized mouse model of arthritis consisting of transgenic mice in which arthritis was induced by immunization with type II collagen (as previously described by Taneja et al., 2007). Collinsella increased gut permeability by reducing the expression of tight junction protein in the human intestinal epithelial cell line CACO-2, and it induced production of the proinflammatory cytokine interleukin (IL)-17A. In addition, Collinsella enhanced disease severity in a humanized mouse model. The dysbiotic gut microbiota in patients with RA stemmed from an expansion of rare microbial lineages like Eggerthella and Collinsella and from a decrease in the abundant beneficial genera like Faecalibacterium. A gut microbial profile for RA patients was identified based on the abundance of the three genera: Collinsella, Eggerthella, and Faecalibacterium.[PMID 27448997]

A significant association was observed between commensal microbial composition and clinical response to anti-PD-1-based immunotherapy. Bacterial species more abundant in responders included Bifidobacterium longum, Collinsella aerofaciens, and Enterococcus faecium. PMID: 29302014



Microbial Abundance Data: Collinsella
(Percent of total population with standard deviation [PMID: 22698087])
Group 1
Group 2
Group 3
Group 4
Group 1 Avg
Buccal
Mucosa
Keratinized
Gingiva
Hard
Palate
Group 2 Avg
Throat
Throat
Tonsils
Saliva
Group 3 Avg
Supragingival
Plaque
Subgingival
Plaque
Stool
0.001 %
(0.006)
0.000 %
(0.002)
0.000 %
(0.000)
0.002 %
(0.016)
0.000 %
(0.003)
0.001 %
(0.007)
0.000 %
(0.002)
0.000 %
(0.000)
0.000 %
(0.002)
0.000 %
(0.001)
0.000 %
(0.002)
0.000 %
(0.000)
0.100 %
(0.216)
TAGS
Keystone
Core species
Type species
Pathogen
Dysbiosis associated
Flora/ commensal
Gut associated
Probiotic
Leanness
Obesity
Skin microbiome
Fecal distribution
Oral microbiome
Vaginal microbiome
Butyrate producer
Catalase producer
Histamine producer
Food fermenter
Amylolytic
Propionate producer
Nitrifying
Biofilm producer
DESCENDANTS
INTERACTIONS
ENHANCES
  • Bacteroidales
  • Bacteroides
  • Odoribacter
  • Peptococcaceae

  • INHIBITS
  • Bifidobacterium
  • Coriobacteriales
  • Adlercreutzia
  • Collinsella
  • Porphyromonas
  • Prevotella
  • Clostridium
  • Clostridiales incertae sedis
  • Clostridiales Family XIII. Incertae Sedis
  • Blautia
  • Coprococcus
  • Dorea
  • Lachnospiraceae
  • Ruminococcaceae
  • Ruminococcus
  • Dialister
  • Campylobacteraceae
  • Erysipelotrichaceae

  • INHIBITED BY
  • Bifidobacterium
  • Coriobacteriales
  • Adlercreutzia
  • Collinsella
  • Bacteroidales
  • Bacteroides
  • Porphyromonadaceae
  • Odoribacter
  • Parabacteroides
  • Porphyromonas
  • Prevotella
  • Rikenellaceae
  • Alistipes
  • Turicibacter
  • Streptococcus
  • Clostridiales
  • Catabacteriaceae
  • Clostridium
  • Clostridiales incertae sedis
  • Peptoniphilus
  • Clostridiales Family XIII. Incertae Sedis
  • Lachnospiraceae
  • Blautia
  • Lachnospiraceae
  • Coprococcus
  • Dorea
  • Eubacterium
  • Lachnobacterium
  • Lachnospira
  • Roseburia
  • Lachnospiraceae
  • Peptococcaceae
  • Ruminococcaceae
  • Ruminiclostridium
  • Acetivibrio
  • Eubacterium
  • Faecalibacterium
  • Oscillospira
  • Ruminococcus
  • Acidaminococcus
  • Dialister
  • Phascolarctobacterium
  • Veillonella
  • Rubrivivax
  • Alcaligenaceae
  • Oxalobacter
  • Bilophila
  • Desulfovibrio
  • Campylobacteraceae
  • Enterobacteriaceae
  • Escherichia
  • Erysipelotrichaceae
  • Erysipelotrichaceae
  • Holdemania
  • Akkermansia
  • KEGG PATHWAYS

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