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Lactobacillus salivarius

RANK: Species

TAXONOMY: Terrabacteria group -> Firmicutes -> Bacilli -> Lactobacillales -> Lactobacillaceae -> Lactobacillus -> Lactobacillus salivarius

OVERVIEW:

L. salivarius is somewhat unique among probiotic strains in that it is capable of growing in less than ideal conditions, including environments high in salt, and with or without oxygen. It is found in the oral cavities (mouth, throat, and sinuses), intestines, and vagina, but grows best in the small intestine. Research has shown that people taking L. salivarius had increased markers of immune activity. An additional study found that supplementing with L. salivarius helps to prevent the colonization of undesirable bacteria. Identified as a constituent of the oral microbiome by Human Oral Microbiome Database. Identified as constituent of vaginal microbiome. [PMID:23282177]

This species has been identified as a resident in the human gastrointestinal tract based on the phylogenetic framework of its small subunit ribosomal RNA gene sequences.[PMC 4262072]

COGEM
COGEM released a comprehensive database of pathogenicity assessment of around 2575 bacterial species in 2011. The database ranks the pathogenicity of species on a scale of 1 to 4. Lactobacillus salivarius ranks on this scale:


TAGS
Keystone
Core species
Type species
Pathogen
Dysbiosis associated
Flora/ commensal
Gut associated
Probiotic
Leanness
Obesity
Skin microbiome
Fecal distribution
Oral microbiome
Vaginal microbiome
Butyrate producer
Catalase producer
Histamine producer
Food fermenter
Amylolytic
Propionate producer
Nitrifying
Biofilm producer
INTERACTIONS
KEGG PATHWAYS

CLUSTERS WITH
Group 149
  • Streptococcus mutans
  • Lactobacillus salivarius
  • Group 122
  • Lactobacillus salivarius
  • Lactobacillus brevis
  • Group 2
  • Leuconostoc mesenteroides
  • Lactobacillus salivarius
  • Lactobacillus acidophilus
  • Bifidobacterium adolescentis
  • Lactobacillus plantarum
  • Streptococcus thermophilus
  • Oenococcus oeni
  • Listeria monocytogenes
  • Lactobacillus gasseri
  • Chloroflexus aurantiacus
  • Bacillus pumilus
  • Pediococcus pentosaceus
  • Bacillus licheniformis
  • Listeria innocua
  • Lactobacillus sakei
  • Clostridium acetobutylicum
  • Bifidobacterium longum
  • Lactobacillus johnsonii
  • Lactobacillus brevis
  • Lactococcus lactis
  • Streptococcus gordonii
  • Lactobacillus delbrueckii
  • Group 15
  • Streptococcus mutans
  • Leuconostoc mesenteroides
  • Lactobacillus salivarius
  • Lactobacillus johnsonii
  • Streptococcus thermophilus
  • Oenococcus oeni
  • Listeria monocytogenes
  • Lactobacillus brevis
  • Hahella chejuensis
  • Pediococcus pentosaceus
  • Listeria innocua
  • Lactobacillus delbrueckii
  • Lactobacillus sakei
  • Group 22
  • Streptococcus mutans
  • Lactobacillus salivarius
  • Porphyromonas gingivalis
  • Streptococcus sanguinis
  • Streptococcus pyogenes
  • Treponema denticola
  • Streptococcus gordonii
  • Streptococcus suis
  • Gramella forsetii
  • Group 4
  • Streptococcus mutans
  • Leuconostoc mesenteroides
  • Lactobacillus salivarius
  • Lactobacillus acidophilus
  • Bifidobacterium adolescentis
  • Streptococcus thermophilus
  • Lactobacillus gasseri
  • Pediococcus pentosaceus
  • Clostridium perfringens
  • Listeria innocua
  • Lactobacillus sakei
  • Bifidobacterium longum
  • Lactobacillus johnsonii
  • Streptococcus sanguinis
  • Lactobacillus casei
  • Lactobacillus brevis
  • Streptococcus gordonii
  • Lactobacillus delbrueckii
  • Group 151
  • Lactobacillus salivarius
  • Lactobacillus delbrueckii
  • Group 23
  • Yersinia pseudotuberculosis
  • Listeria welshimeri
  • Lactobacillus salivarius
  • Yersinia pestis
  • Lactobacillus johnsonii
  • Listeria monocytogenes
  • Salmonella enterica
  • Aeromonas hydrophila
  • Lawsonia intracellularis
  • Shigella flexneri
  • Corynebacterium jeikeium
  • Listeria innocua
  • Lactobacillus sakei
  • Group 148
  • Lactobacillus salivarius
  • Lactobacillus gasseri
  • Group 150
  • Lactobacillus salivarius
  • Lactobacillus johnsonii
  • METABOLOMICS       
    NUTRIENTS/ SUBSTRATES
  • Raffinose
  • Ellagic acid [parent]
  • D-Glucose [parent]
  • CO2 [parent]
  • α-Glucan [parent]
  • Stachyose (soy oligosaccharide)

  • ENDPRODUCTS
  • Urolithins [parent]
  • Lactate [parent]
  • Acetylcholine [parent]
  • γ-Amino butyric acid (GABA) [parent]
  • Vitamin B12 [parent]
  • Trimethylamine [parent]
  • Lactic acid [parent]

  • INHIBITED BY
  • Stevia [parent]
  • Laminaria hyperborea (curvie) [parent]
  • Chemotherapy [parent]
  • Magnesium-deficient diet [parent]
  • Glyphosphate [parent]
  • High fat diet [parent]
  • Sucralose (Splenda) [parent]

  • ENHANCED BY
  • Sesame cake/meal [parent]
  • Almonds/ almond skins [parent]
  • Navy bean (Cooked) [parent]
  • Magnesium [parent]
  • Daesiho-tang (DSHT) [parent]
  • Resveratrol [parent]
  • Proton-pump inhibitors (PPI) [parent]
  • Laminaria digitata (oarweed) [parent]

  • BIOTRANSFORMS
  • Linoleic acid (LA) [parent]
  • Linolenic acid (CLnA) [parent]

  • BIOTRANFORM
  • 10‐Hydroxy‐cis‐12‐octadecenoate (HYA) [parent]
  • Trans-11 conjugate linoleic acid (CLA) [parent]
  • Cis-9 conjugate linoleic acid (CLA) [parent]
  • Cis-15 conjugate linolenic acids (CLnA) [parent]
  • Cis-9 conjugate linolenic acids (CLnA) [parent]
  • 10-Hydroxyoctadecanoate (HYB) [parent]
  • Trans-11 conjugate linolenic acids (CLnA) [parent]
  • ANTIBIOTIC RESISTANCE   BIOFILM FORMERS   COGEM PATHOGENICITY   

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