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Rothia

RANK: Genus

TAXONOMY: Bacteria -> Terrabacteria group -> Actinobacteria -> Actinobacteria -> Micrococcales -> Micrococcaceae -> Rothia

OVERVIEW:

Agenus of bacteria in the family Micrococcaceae. Babies with a higher risk of asthma presented lower levels of four bacteria in their feces samples in comparison with the infants who did not show any symptoms. Those bacteria were identified as Faecalibacterium, Lachnospira, Veillonella and Rothia - known all together as FLVR. [http://www.gutmicrobiotawatch.org/en/2015/11/25/four-types-of-gut-bacteria-may-protect-children-against-asthma-risk/] Identified as constituent of skin microbiome. [PMC2746716]

Coccoid, spherical, dipththeroid, filamentous mycelial cells, usually up to 1.0 µm in diameter. Irregular swellings and clubbed ends up to 5.0 µm in diameter may be present. Growth may be exclusively coccoid, diphtheroid, or filamentous or a mixture of these forms. Gram-stain-positive. Nonmotile. Endospores are absent. Non acid-fast. Mature colonies (4–7 d) 2–6 mm in diameter, usually off-white/cream, smooth or rough, usually soft in texture but may be dry and crumbly or mucoid. Optimum temperature for growth is 30–37°C. Usually catalase-positive. Chemo-organotrophic. Ferments carbohydrates. Major product of glucose fermentation is lactic acid. Does not produce propionic acid. The cell-wall peptidoglycan type is A3α, and contains alanine, glutamic acid, and lysine, but not diaminopimelic acid (DAP). Contains MK-7 as the major isoprenoid quinone. Cell-wall sugars include fructose, galactose, and glucose, but not 6-deoxy-talose or arabinose. DNA G+C content (mol%): 54–60 (Tm) Type species: Rothia dentocariosa

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072]

Microbial Abundance Data: Rothia
(Percent of total population with standard deviation [PMID: 22698087])
Group 1
Group 2
Group 3
Group 4
Group 1 Avg
Buccal
Mucosa
Keratinized
Gingiva
Hard
Palate
Group 2 Avg
Throat
Throat
Tonsils
Saliva
Group 3 Avg
Supragingival
Plaque
Subgingival
Plaque
Stool
1.592 %
(2.460)
2.277 %
(3.858)
0.277 %
(0.772)
2.223 %
(2.749)
1.284 %
(1.845)
1.073 %
(1.494)
0.819 %
(1.239)
2.243 %
(3.064)
1.001 %
(1.581)
4.559 %
(5.981)
5.444 %
(6.814)
3.675 %
(5.148)
0.002 %
(0.012)
TAGS
Keystone Core species Type species Pathogen Dysbiosis associated Flora/ commensal Gut associated Probiotic
Leanness Obesity Skin microbiome Fecal distribution Oral microbiome Vaginal microbiome Butyrate producer Catalase producer
Histamine producer Food fermenter Amylolytic Propionate producer Nitrifying
DESCENDANTS
INTERACTIONS
KEGG PATHWAYS
  • 2-Oxocarboxylic acid metabolism
  • ABC transporters
  • Alanine, aspartate and glutamate metabolism
  • Amino sugar and nucleotide sugar metabolism
  • Aminoacyl-tRNA biosynthesis
  • Arginine and proline metabolism
  • Arginine biosynthesis
  • Bacterial secretion system
  • Base excision repair
  • Biosynthesis of amino acids
  • Biosynthesis of antibiotics
  • Biosynthesis of secondary metabolites
  • Biosynthesis of siderophore group nonribosomal peptides
  • Biosynthesis of unsaturated fatty acids
  • Biotin metabolism
  • Butanoate metabolism
  • C5-Branched dibasic acid metabolism
  • Carbon metabolism
  • Chloroalkane and chloroalkene degradation
  • Citrate cycle (TCA cycle)
  • Cyanoamino acid metabolism
  • Cysteine and methionine metabolism
  • D-Alanine metabolism
  • D-Glutamine and D-glutamate metabolism
  • DNA replication
  • Degradation of aromatic compounds
  • Fatty acid biosynthesis
  • Fatty acid degradation
  • Fatty acid metabolism
  • Folate biosynthesis
  • Fructose and mannose metabolism
  • Galactose metabolism
  • Glutathione metabolism
  • Glycerolipid metabolism
  • Glycerophospholipid metabolism
  • Glycine, serine and threonine metabolism
  • Glycolysis / Gluconeogenesis
  • Glyoxylate and dicarboxylate metabolism
  • Histidine metabolism
  • Homologous recombination
  • Insulin resistance
  • Lipoic acid metabolism
  • Lysine biosynthesis
  • Lysine degradation
  • Metabolic pathways
  • Methane metabolism
  • Microbial metabolism in diverse environments
  • Mismatch repair
  • Monobactam biosynthesis
  • Naphthalene degradation
  • Nicotinate and nicotinamide metabolism
  • Nitrogen metabolism
  • Nonribosomal peptide structures
  • Novobiocin biosynthesis
  • Nucleotide excision repair
  • One carbon pool by folate
  • Oxidative phosphorylation
  • Pantothenate and CoA biosynthesis
  • Pentose and glucuronate interconversions
  • Pentose phosphate pathway
  • Peptidoglycan biosynthesis
  • Phenylalanine metabolism
  • Phenylalanine, tyrosine and tryptophan biosynthesis
  • Phosphotransferase system (PTS)
  • Polyketide sugar unit biosynthesis
  • Porphyrin and chlorophyll metabolism
  • Propanoate metabolism
  • Protein export
  • Purine metabolism
  • Pyrimidine metabolism
  • Pyruvate metabolism
  • RNA degradation
  • RNA polymerase
  • Riboflavin metabolism
  • Ribosome
  • Selenocompound metabolism
  • Starch and sucrose metabolism
  • Streptomycin biosynthesis
  • Sulfur metabolism
  • Sulfur relay system
  • Taurine and hypotaurine metabolism
  • Terpenoid backbone biosynthesis
  • Thiamine metabolism
  • Tryptophan metabolism
  • Two-component system
  • Tyrosine metabolism
  • Ubiquinone and other terpenoid-quinone biosynthesis
  • Valine, leucine and isoleucine biosynthesis
  • Valine, leucine and isoleucine degradation
  • Vancomycin resistance
  • Vitamin B6 metabolism
  • beta-Alanine metabolism

  • CLUSTERS WITH
    METABOLOMICS       
    NUTRIENTS/ SUBSTRATES
  • D-Glucose
  • Gluten

  • ENDPRODUCTS
  • Lactic acid

  • INHIBITED BY

    ENHANCED BY
  • Proton-pump inhibitors (PPI)

  • BIOTRANSFORMS

    BIOTRANFORM

    ANTIBIOTIC RESISTANCE
  • Tetracycline (tetw)

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