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Porphyromonas gingivalis

RANK: Species

TAXONOMY: Bacteroidetes/Chlorobi group -> Bacteroidetes -> Bacteroidia -> Bacteroidales -> Porphyromonadaceae -> Porphyromonas -> Porphyromonas gingivalis

OVERVIEW:

Identified as a constituent of the oral microbiome by Human Oral Microbiome Database. Identified as constituent of vaginal microbiome. [PMID:23282177] Porphyromonas gingivalis belongs to the phylum Bacteroidetes and is a nonmotile, Gram-negative, rod-shaped, anaerobic, pathogenic bacterium. It forms black colonies on blood agar. It is found in the oral cavity, where it is implicated in certain forms of periodontal disease, as well as the upper gastrointestinal tract, respiratory tract, and in the colon. It has also been isolated from women with bacterial vaginosis. Collagen degradation observed in chronic periodontal disease results in part from the collagenase enzymes of this species. It has been shown in an in vitro study that P. gingivalis can invade human gingival fibroblasts and can survive in them in the presence of considerable concentrations of antibiotics. P. gingivalis also invades gingival epithelial cells in high numbers, in which cases both bacteria and epithelial cells survive for extended periods of time. High levels of specific antibodies can be detected in patients harboring P. gingivalis. In addition, P. gingivalis has been linked to rheumatoid arthritis. It contains the enzyme peptidyl-arginine deiminase, which is involved in citrullination. Patients with rheumatoid arthritis have an increased incidence of periodontal disease[citation needed] and antibodies against the bacterium are significantly more common in these patients.


This species has been identified as a resident in the human gastrointestinal tract based on the phylogenetic framework of its small subunit ribosomal RNA gene sequences.[PMC 4262072]

TAGS
Keystone Core species Type species Pathogen Dysbiosis associated Flora/ commensal Gut associated Probiotic
Leanness Obesity Skin microbiome Fecal distribution Oral microbiome Vaginal microbiome Butyrate producer Catalase producer
Histamine producer Food fermenter Amylolytic Propionate producer Nitrifying
INTERACTIONS
ENHANCES
  • Bacteroidales
  • Bacteroides
  • Odoribacter
  • Peptococcaceae

  • INHIBITS
  • Bifidobacterium
  • Coriobacteriales
  • Adlercreutzia
  • Collinsella
  • Porphyromonas
  • Prevotella
  • Clostridium
  • Clostridiales incertae sedis
  • Clostridiales Family XIII. Incertae Sedis
  • Blautia
  • Coprococcus
  • Dorea
  • Lachnospiraceae
  • Ruminococcaceae
  • Ruminococcus
  • Dialister
  • Campylobacteraceae
  • Erysipelotrichaceae

  • INHIBITED BY
  • Bifidobacterium
  • Coriobacteriales
  • Adlercreutzia
  • Collinsella
  • Bacteroidales
  • Bacteroides
  • Porphyromonadaceae
  • Odoribacter
  • Parabacteroides
  • Porphyromonas
  • Prevotella
  • Rikenellaceae
  • Alistipes
  • Turicibacter
  • Streptococcus
  • Clostridiales
  • Catabacteriaceae
  • Clostridium
  • Clostridiales incertae sedis
  • Peptoniphilus
  • Clostridiales Family XIII. Incertae Sedis
  • Lachnospiraceae
  • Blautia
  • Lachnospiraceae
  • Coprococcus
  • Dorea
  • Eubacterium
  • Lachnobacterium
  • Lachnospira
  • Roseburia
  • Lachnospiraceae
  • Peptococcaceae
  • Ruminococcaceae
  • Ruminiclostridium
  • Acetivibrio
  • Eubacterium
  • Faecalibacterium
  • Oscillospira
  • Ruminococcus
  • Acidaminococcus
  • Dialister
  • Phascolarctobacterium
  • Veillonella
  • Rubrivivax
  • Alcaligenaceae
  • Oxalobacter
  • Bilophila
  • Desulfovibrio
  • Campylobacteraceae
  • Enterobacteriaceae
  • Escherichia
  • Erysipelotrichaceae
  • Erysipelotrichaceae
  • Holdemania
  • Akkermansia
  • KEGG PATHWAYS

    CLUSTERS WITH
    Group 22
  • Streptococcus mutans
  • Lactobacillus salivarius
  • Porphyromonas gingivalis
  • Streptococcus sanguinis
  • Streptococcus pyogenes
  • Treponema denticola
  • Streptococcus gordonii
  • Streptococcus suis
  • Gramella forsetii
  • Group 160
  • Porphyromonas gingivalis
  • Campylobacter concisus
  • Group 47
  • Streptococcus mutans
  • Porphyromonas gingivalis
  • Streptococcus sanguinis
  • Treponema denticola
  • Campylobacter concisus
  • Fusobacterium nucleatum
  • Streptococcus gordonii
  • Campylobacter curvus
  • Propionibacterium acnes
  • Group 5
  • Staphylococcus epidermidis
  • Lactobacillus acidophilus
  • Bifidobacterium adolescentis
  • Chloroflexus aurantiacus
  • Neisseria gonorrhoeae
  • Saccharophagus degradans
  • Cytophaga hutchinsonii
  • Bacteroides fragilis
  • Clostridium perfringens
  • Enterobacter
  • Propionibacterium acnes
  • Gramella forsetii
  • Clostridium acetobutylicum
  • Staphylococcus aureus
  • Porphyromonas gingivalis
  • Bifidobacterium longum
  • Colwellia psychrerythraea
  • Pseudomonas aeruginosa
  • Bacteroides thetaiotaomicron
  • Haemophilus influenzae
  • Peptoclostridium difficile
  • Fusobacterium nucleatum
  • METABOLOMICS       
    NUTRIENTS/ SUBSTRATES

    ENDPRODUCTS

    INHIBITED BY
  • Epicatechin
  • Whole-grain barley [parent]
  • (+)-Catechin
  • Garlic (allicin) [parent]
  • β-Glucan [parent]

  • ENHANCED BY

    BIOTRANSFORMS

    BIOTRANFORM

    ANTIBIOTIC RESISTANCE

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