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Prevotella

RANK: Genus

TAXONOMY: Bacteria -> Bacteroidetes/Chlorobi group -> Bacteroidetes -> Bacteroidia -> Bacteroidales -> Prevotellaceae -> Prevotella

OVERVIEW:

Prevotella is a genus of Gram-negative bacteria. Bacteroides melaninogenicus has been reclassified and split into Prevotella melaninogenica and Prevotella intermedia. Prevotella spp. are members of the oral and vaginal flora, and are recovered from anaerobic infections of the respiratory tract. These infections include aspiration pneumonia, lung abscess, pulmonary empyema, and chronic otitis media and sinusitis. They have been isolated from abscesses and burns in the vicinity of the mouth, bites, paronychia, urinary tract infection, brain abscesses, osteomyelitis, and bacteremia associated with upper respiratory tract infections. Prevotella spp. predominate in periodontal disease and periodontal abscesses. In a study of gut bacteria of children in Burkina Faso (in Africa), Prevotella made up 53% of the gut bacteria, but were absent in age-matched European children. Studies also indicate that long-term diet is strongly associated with the gut microbiome composition—those who eat plenty of protein and animal fats typical of Western diet have predominantly Bacteroides bacteria, while for those who consume more carbohydrates, especially fibre, the Prevotella species dominate. P. copri is possibly connected to rheumatoid arthritis. A recent study on Prevotella derived from humans compared the gene repertoires of its species derived from different body sites of human. It also reported an open pan- genome showing vast diversity of gene pool. A lower ratio of Bacteroides to Prevotella is reputed to identify the type 2 'enterotype.' [PMC 3728647] Prevotella were enriched in children with a high-fiber diet in a rural African village of Burkina Faso and in children and adults in Malawi and Venezuelan populations with diets dominated by maize-, cassava-, and other plant-derived polysaccharides. [PMID 20679230]

Short rods. Nonsporeforming. Nonmotile. Gram-stain-negative. Anaerobic. Moderately saccharolytic. Growth is inhibited by 20% bile. Succinic and acetic acids are the major metabolic end products in peptone-yeast extract-glucose (PYG) broth, but lower levels of other short-chain acids may be produced. Malate dehydrogenase and glutamate dehydrogenase are present, but glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase are absent. Sphingolipids are produced. The nonhydroxylated long-chain fatty acids are primarily of the straight-chain saturated and monounsaturated types; methyl branched fatty acids are either absent or present in small amounts. Porphyrins are produced by pigmented species, while menaquinones are the sole respiratory quinones found in all species so far studied. Diaminopimelic acid is the only dibasic amino acid in the peptidoglycan (Miyagawa et al., 1981). Neither heptose nor 2-keto-3-deoxyoctulosonic acid has so far been reported (Hofstad, 1974). The primary site of isolation is the oral cavity, but more recently species have been reported from the intestinal tract of man and animals.DNA G+C content (mol%) of most species: 40–52. Type species: Prevotella melaninogenica

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072] Identified as a 'core species' of the human gut microbiome. [PMID: 23222524]

Microbial Abundance Data: Prevotella
(Percent of total population with standard deviation [PMID: 22698087])
Group 1
Group 2
Group 3
Group 4
Group 1 Avg
Buccal
Mucosa
Keratinized
Gingiva
Hard
Palate
Group 2 Avg
Throat
Throat
Tonsils
Saliva
Group 3 Avg
Supragingival
Plaque
Subgingival
Plaque
Stool
3.664 %
(3.230)
2.375 %
(2.756)
0.930 %
(1.383)
7.688 %
(5.549)
11.562 %
(7.339)
11.613 %
(7.181)
11.395 %
(8.679)
10.259 %
(6.362)
12.981 %
(7.136)
5.626 %
(5.958)
3.213 %
(4.139)
8.039 %
(7.777)
3.163 %
(9.571)
TAGS
Keystone Core species Type species Pathogen Dysbiosis associated Flora/ commensal Gut associated Probiotic
Leanness Obesity Skin microbiome Fecal distribution Oral microbiome Vaginal microbiome Butyrate producer Catalase producer
Histamine producer Food fermenter Amylolytic Propionate producer Nitrifying
DESCENDANTS
  • Prevotella aff. ruminicola Tc2-24
  • Prevotella albensis
  • Prevotella amnii
  • Prevotella aurantiaca
  • Prevotella baroniae
  • Prevotella bergensis
  • Prevotella bivia
  • Prevotella brevis
  • Prevotella bryantii
  • Prevotella buccae
  • Prevotella buccalis
  • Prevotella conceptionensis
  • Prevotella copri
  • Prevotella corporis
  • Prevotella dentalis
  • Prevotella dentasini
  • Prevotella denticola
  • Prevotella disiens
  • Prevotella enoeca
  • Prevotella falsenii
  • Prevotella fusca
  • Prevotella histicola
  • Prevotella intermedia
  • Prevotella jejuni
  • Prevotella loescheii
  • Prevotella maculosa
  • Prevotella marshii
  • Prevotella massiliensis
  • Prevotella melaninogenica
  • Prevotella micans
  • Prevotella multiformis
  • Prevotella multisaccharivorax
  • Prevotella nanceiensis
  • Prevotella nigrescens
  • Prevotella oralis
  • Prevotella oris
  • Prevotella oryzae
  • Prevotella oulorum
  • Prevotella pallens
  • Prevotella paludivivens
  • Prevotella pleuritidis
  • Prevotella ruminicola
  • Prevotella saccharolytica
  • Prevotella salivae
  • Prevotella scopos
  • Prevotella shahii
  • Prevotella sp.
  • Prevotella sp. BV3C7
  • Prevotella sp. S4-10
  • Prevotella sp. WAL 2039G
  • Prevotella sp. oral taxon 292
  • Prevotella sp. oral taxon 293
  • Prevotella sp. oral taxon 296
  • Prevotella sp. oral taxon 299
  • Prevotella sp. oral taxon 300
  • Prevotella sp. oral taxon 301
  • Prevotella sp. oral taxon 304
  • Prevotella sp. oral taxon 305
  • Prevotella sp. oral taxon 306
  • Prevotella sp. oral taxon 309
  • Prevotella sp. oral taxon 310
  • Prevotella sp. oral taxon 313
  • Prevotella sp. oral taxon 314
  • Prevotella sp. oral taxon 315
  • Prevotella sp. oral taxon 317
  • Prevotella sp. oral taxon 376
  • Prevotella sp. oral taxon 396
  • Prevotella sp. oral taxon 443
  • Prevotella sp. oral taxon 472
  • Prevotella sp. oral taxon 475
  • Prevotella sp. oral taxon 515
  • Prevotella sp. oral taxon 526
  • Prevotella sp. oral taxon G60
  • Prevotella stercorea
  • Prevotella timonensis
  • Prevotella veroralis
  • environmental samples
  • INTERACTIONS
    ENHANCES
  • Bacteroidales
  • Bacteroides
  • Odoribacter
  • Peptococcaceae

  • INHIBITS
  • Bifidobacterium
  • Coriobacteriales
  • Adlercreutzia
  • Collinsella
  • Porphyromonas
  • Prevotella
  • Clostridium
  • Clostridiales incertae sedis
  • Clostridiales Family XIII. Incertae Sedis
  • Blautia
  • Coprococcus
  • Dorea
  • Lachnospiraceae
  • Ruminococcaceae
  • Ruminococcus
  • Dialister
  • Campylobacteraceae
  • Erysipelotrichaceae

  • INHIBITED BY
  • Bifidobacterium
  • Coriobacteriales
  • Adlercreutzia
  • Collinsella
  • Bacteroidales
  • Bacteroides
  • Porphyromonadaceae
  • Odoribacter
  • Parabacteroides
  • Porphyromonas
  • Prevotella
  • Rikenellaceae
  • Alistipes
  • Turicibacter
  • Streptococcus
  • Clostridiales
  • Catabacteriaceae
  • Clostridium
  • Clostridiales incertae sedis
  • Peptoniphilus
  • Clostridiales Family XIII. Incertae Sedis
  • Lachnospiraceae
  • Blautia
  • Lachnospiraceae
  • Coprococcus
  • Dorea
  • Eubacterium
  • Lachnobacterium
  • Lachnospira
  • Roseburia
  • Lachnospiraceae
  • Peptococcaceae
  • Ruminococcaceae
  • Ruminiclostridium
  • Acetivibrio
  • Eubacterium
  • Faecalibacterium
  • Oscillospira
  • Ruminococcus
  • Acidaminococcus
  • Dialister
  • Phascolarctobacterium
  • Veillonella
  • Rubrivivax
  • Alcaligenaceae
  • Oxalobacter
  • Bilophila
  • Desulfovibrio
  • Campylobacteraceae
  • Enterobacteriaceae
  • Escherichia
  • Erysipelotrichaceae
  • Erysipelotrichaceae
  • Holdemania
  • Akkermansia
  • KEGG PATHWAYS
  • 2-Oxocarboxylic acid metabolism
  • ABC transporters
  • Alanine, aspartate and glutamate metabolism
  • Amino sugar and nucleotide sugar metabolism
  • Aminoacyl-tRNA biosynthesis
  • Arachidonic acid metabolism
  • Arginine and proline metabolism
  • Arginine biosynthesis
  • Bacterial secretion system
  • Base excision repair
  • Biosynthesis of amino acids
  • Biosynthesis of antibiotics
  • Biosynthesis of secondary metabolites
  • Biosynthesis of unsaturated fatty acids
  • Biotin metabolism
  • Butanoate metabolism
  • Carbon metabolism
  • Cationic antimicrobial peptide (CAMP) resistance
  • Citrate cycle (TCA cycle)
  • Cyanoamino acid metabolism
  • Cysteine and methionine metabolism
  • D-Alanine metabolism
  • D-Glutamine and D-glutamate metabolism
  • DNA replication
  • Fatty acid biosynthesis
  • Fatty acid metabolism
  • Folate biosynthesis
  • Fructose and mannose metabolism
  • Galactose metabolism
  • Glutathione metabolism
  • Glycerolipid metabolism
  • Glycerophospholipid metabolism
  • Glycine, serine and threonine metabolism
  • Glycolysis / Gluconeogenesis
  • Glyoxylate and dicarboxylate metabolism
  • Histidine metabolism
  • Homologous recombination
  • Inositol phosphate metabolism
  • Insulin resistance
  • Lipoic acid metabolism
  • Lipopolysaccharide biosynthesis
  • Lysine biosynthesis
  • Metabolic pathways
  • Methane metabolism
  • Microbial metabolism in diverse environments
  • Mismatch repair
  • Monobactam biosynthesis
  • Nicotinate and nicotinamide metabolism
  • Nitrogen metabolism
  • Novobiocin biosynthesis
  • Nucleotide excision repair
  • One carbon pool by folate
  • Other glycan degradation
  • Oxidative phosphorylation
  • Pantothenate and CoA biosynthesis
  • Pentose and glucuronate interconversions
  • Pentose phosphate pathway
  • Peptidoglycan biosynthesis
  • Phenylalanine metabolism
  • Phenylalanine, tyrosine and tryptophan biosynthesis
  • Polyketide sugar unit biosynthesis
  • Porphyrin and chlorophyll metabolism
  • Propanoate metabolism
  • Protein export
  • Purine metabolism
  • Pyrimidine metabolism
  • Pyruvate metabolism
  • RNA degradation
  • RNA polymerase
  • Riboflavin metabolism
  • Ribosome
  • Selenocompound metabolism
  • Sphingolipid metabolism
  • Starch and sucrose metabolism
  • Streptomycin biosynthesis
  • Sulfur metabolism
  • Taurine and hypotaurine metabolism
  • Terpenoid backbone biosynthesis
  • Thiamine metabolism
  • Two-component system
  • Tyrosine metabolism
  • Ubiquinone and other terpenoid-quinone biosynthesis
  • Valine, leucine and isoleucine biosynthesis
  • Valine, leucine and isoleucine degradation
  • Vancomycin resistance
  • Vitamin B6 metabolism
  • beta-Alanine metabolism
  • beta-Lactam resistance

  • CLUSTERS WITH
    METABOLOMICS       

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