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Roseburia

RANK: Genus

TAXONOMY: Bacteria -> Terrabacteria group -> Firmicutes -> Clostridia -> Clostridiales -> Lachnospiraceae -> Roseburia

OVERVIEW:

A genus of butyrate-producing, Gram-positive anaerobic bacteria that inhabit the human colon. Named in honor of Theodor Rosebury, they are members of the phylum firmicutes. Increased abundance of Roseburia is associated with weight loss and reduced glucose intolerance. Roseburia favors and loves starches that escape small intestinal degradation and RS3, cooked-cooled starches. R. intestinalis works synergistically often with Bifidobacteria. On very low carbohydrate diets, Roseburia drops along with starch intakes. What is most bothersome is that butyrate dips 4-fold as well. Chitin and beta-glucan encourage Roseburia (as does low dose RS2, green banana flour or RPS) A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Roseburia residing in our gut microbiomes help us to digest the complex carbohydrates found in whole grains. As a byproduct of that digestion, these beneficial bacteria release the short chain fatty acid butyrate which may act as an anti-inflammatory and prevent colon cancer.

Slightly curved, rod-shaped cells (0.5 × 1.5–5 µm) occur singly and in (dividing) pairs. Nonsporulating. Gram-negative to Gram-variable staining reaction. Taxonomically grouped within cluster XIVa of the Clostridium subphylum on the basis of 16S rDNA sequence (see below). Actively motile at 37 °C by means of multiple flagella inserted along the concave side and occasionally along one end of the cell. The flagella appear as a subterminal bundle when cells are examined by scanning electron microscopy or phase-contrast light microscopy (Figure 168). Strictly anaerobic. Chemo-organotrophic. Uses the carbohydrates d-glucose, cellobiose, d-maltose, d-raffinose, sucrose, and d-xylose as carbon and energy sources. Hydrolyzes and ferments starch. Grows in anaerobically prepared media containing volatile fatty acids, yeast extract, trypticase peptone, inorganic salts, hemin, glucose, and vitamins, beneath 95% N2/5% CO2 or 100% CO2 atmosphere. Produces H2, CO2, and large amounts of butyrate from fermentation of glucose and acetate. May produce lactate, formate, and trace amounts of ethanol. Consumes acetate, which may be stimulatory during growth on carbohydrates. Indigenous to mammalian intestinal tract. Catalase-negative. Isolated from mouse cecal mucosa and from human feces. Uncultured bacteria with partial 16S rDNA sequences 95–97% similar to those of Roseburia (GenBank nos AJ312385 and L14676) have been detected in 16S rDNA analyses of swine gastrointestinal tract samples (Leser et al., 2002) and adult human fecal samples (Hold et al., 2002). Two species of Roseburia have been characterized. They can be differentiated by characteristics given in Table 171. DNA G+C content (mol%): 29–42% (Tm). Type species: Roseburia cecicola

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072] Decreased in metabolic disorders.

Microbial Abundance Data: Roseburia
(Percent of total population with standard deviation [PMID: 22698087])
Group 1
Group 2
Group 3
Group 4
Group 1 Avg
Buccal
Mucosa
Keratinized
Gingiva
Hard
Palate
Group 2 Avg
Throat
Throat
Tonsils
Saliva
Group 3 Avg
Supragingival
Plaque
Subgingival
Plaque
Stool
0.008 %
(0.026)
0.004 %
(0.017)
0.001 %
(0.007)
0.018 %
(0.053)
0.010 %
(0.049)
0.026 %
(0.130)
0.003 %
(0.012)
0.000 %
(0.003)
0.011 %
(0.052)
0.005 %
(0.055)
0.000 %
(0.002)
0.010 %
(0.108)
2.081 %
(2.378)
TAGS
Keystone Core species Type species Pathogen Dysbiosis associated Flora/ commensal Gut associated Probiotic
Leanness Obesity Skin microbiome Fecal distribution Oral microbiome Vaginal microbiome Butyrate producer Catalase producer
Histamine producer Food fermenter Amylolytic Propionate producer Nitrifying
DESCENDANTS
INTERACTIONS
ENHANCES
  • Bacteroidales
  • Bacteroides
  • Odoribacter
  • Peptococcaceae
  • Bacteroidales
  • Bacteroides
  • Odoribacter
  • Peptococcaceae
  • Bacteroidales
  • Bacteroides
  • Odoribacter
  • Peptococcaceae
  • Bacteroidales
  • Bacteroides
  • Odoribacter
  • Peptococcaceae

  • INHIBITS
  • Bifidobacterium
  • Coriobacteriales
  • Adlercreutzia
  • Collinsella
  • Porphyromonas
  • Prevotella
  • Clostridium
  • Clostridiales incertae sedis
  • Clostridiales Family XIII. Incertae Sedis
  • Blautia
  • Coprococcus
  • Dorea
  • Lachnospiraceae
  • Ruminococcaceae
  • Ruminococcus
  • Dialister
  • Campylobacteraceae
  • Erysipelotrichaceae
  • Bifidobacterium
  • Coriobacteriales
  • Adlercreutzia
  • Collinsella
  • Porphyromonas
  • Prevotella
  • Clostridium
  • Clostridiales incertae sedis
  • Clostridiales Family XIII. Incertae Sedis
  • Blautia
  • Coprococcus
  • Dorea
  • Lachnospiraceae
  • Ruminococcaceae
  • Ruminococcus
  • Dialister
  • Campylobacteraceae
  • Erysipelotrichaceae
  • Bifidobacterium
  • Coriobacteriales
  • Adlercreutzia
  • Collinsella
  • Porphyromonas
  • Prevotella
  • Clostridium
  • Clostridiales incertae sedis
  • Clostridiales Family XIII. Incertae Sedis
  • Blautia
  • Coprococcus
  • Dorea
  • Lachnospiraceae
  • Ruminococcaceae
  • Ruminococcus
  • Dialister
  • Campylobacteraceae
  • Erysipelotrichaceae
  • Bifidobacterium
  • Coriobacteriales
  • Adlercreutzia
  • Collinsella
  • Porphyromonas
  • Prevotella
  • Clostridium
  • Clostridiales incertae sedis
  • Clostridiales Family XIII. Incertae Sedis
  • Blautia
  • Coprococcus
  • Dorea
  • Lachnospiraceae
  • Ruminococcaceae
  • Ruminococcus
  • Dialister
  • Campylobacteraceae
  • Erysipelotrichaceae

  • ENHANCED BY
  • Bifidobacterium
  • Faecalibacterium

  • INHIBITED BY
  • Bifidobacterium
  • Coriobacteriales
  • Adlercreutzia
  • Collinsella
  • Bacteroidales
  • Bacteroides
  • Porphyromonadaceae
  • Odoribacter
  • Parabacteroides
  • Porphyromonas
  • Prevotella
  • Rikenellaceae
  • Alistipes
  • Turicibacter
  • Streptococcus
  • Clostridiales
  • Catabacteriaceae
  • Clostridium
  • Clostridiales incertae sedis
  • Peptoniphilus
  • Clostridiales Family XIII. Incertae Sedis
  • Lachnospiraceae
  • Blautia
  • Lachnospiraceae
  • Coprococcus
  • Dorea
  • Eubacterium
  • Lachnobacterium
  • Lachnospira
  • Roseburia
  • Lachnospiraceae
  • Peptococcaceae
  • Ruminococcaceae
  • Ruminiclostridium
  • Acetivibrio
  • Eubacterium
  • Faecalibacterium
  • Oscillospira
  • Ruminococcus
  • Acidaminococcus
  • Dialister
  • Phascolarctobacterium
  • Veillonella
  • Rubrivivax
  • Alcaligenaceae
  • Oxalobacter
  • Bilophila
  • Desulfovibrio
  • Campylobacteraceae
  • Enterobacteriaceae
  • Escherichia
  • Erysipelotrichaceae
  • Erysipelotrichaceae
  • Holdemania
  • Akkermansia
  • KEGG PATHWAYS
  • 2-Oxocarboxylic acid metabolism
  • ABC transporters
  • Alanine, aspartate and glutamate metabolism
  • Amino sugar and nucleotide sugar metabolism
  • Aminoacyl-tRNA biosynthesis
  • Arginine and proline metabolism
  • Arginine biosynthesis
  • Bacterial chemotaxis
  • Bacterial secretion system
  • Base excision repair
  • Biosynthesis of amino acids
  • Biosynthesis of antibiotics
  • Biosynthesis of secondary metabolites
  • Biosynthesis of unsaturated fatty acids
  • Biotin metabolism
  • Butanoate metabolism
  • C5-Branched dibasic acid metabolism
  • Carbapenem biosynthesis
  • Carbon metabolism
  • Cationic antimicrobial peptide (CAMP) resistance
  • Citrate cycle (TCA cycle)
  • Cyanoamino acid metabolism
  • Cysteine and methionine metabolism
  • D-Alanine metabolism
  • D-Glutamine and D-glutamate metabolism
  • DNA replication
  • Fatty acid biosynthesis
  • Fatty acid metabolism
  • Flagellar assembly
  • Folate biosynthesis
  • Fructose and mannose metabolism
  • Galactose metabolism
  • Glutathione metabolism
  • Glycerolipid metabolism
  • Glycerophospholipid metabolism
  • Glycine, serine and threonine metabolism
  • Glycolysis / Gluconeogenesis
  • Glyoxylate and dicarboxylate metabolism
  • Histidine metabolism
  • Homologous recombination
  • Inositol phosphate metabolism
  • Insulin resistance
  • Lysine biosynthesis
  • Metabolic pathways
  • Methane metabolism
  • Microbial metabolism in diverse environments
  • Mismatch repair
  • Monobactam biosynthesis
  • Nicotinate and nicotinamide metabolism
  • Nitrogen metabolism
  • Nitrotoluene degradation
  • Novobiocin biosynthesis
  • Nucleotide excision repair
  • One carbon pool by folate
  • Other glycan degradation
  • Oxidative phosphorylation
  • Pantothenate and CoA biosynthesis
  • Pentose and glucuronate interconversions
  • Pentose phosphate pathway
  • Peptidoglycan biosynthesis
  • Phenylalanine metabolism
  • Phenylalanine, tyrosine and tryptophan biosynthesis
  • Phosphonate and phosphinate metabolism
  • Phosphotransferase system (PTS)
  • Polyketide sugar unit biosynthesis
  • Porphyrin and chlorophyll metabolism
  • Propanoate metabolism
  • Protein export
  • Purine metabolism
  • Pyrimidine metabolism
  • Pyruvate metabolism
  • RNA degradation
  • RNA polymerase
  • Riboflavin metabolism
  • Ribosome
  • Secondary bile acid biosynthesis
  • Selenocompound metabolism
  • Sphingolipid metabolism
  • Starch and sucrose metabolism
  • Streptomycin biosynthesis
  • Sulfur metabolism
  • Sulfur relay system
  • Taurine and hypotaurine metabolism
  • Terpenoid backbone biosynthesis
  • Thiamine metabolism
  • Two-component system
  • Tyrosine metabolism
  • Valine, leucine and isoleucine biosynthesis
  • Valine, leucine and isoleucine degradation
  • Vancomycin resistance
  • Vitamin B6 metabolism
  • beta-Alanine metabolism
  • beta-Lactam resistance

  • CLUSTERS WITH
    METABOLOMICS       
    NUTRIENTS/ SUBSTRATES
  • Raffinose
  • β-Glucan
  • Resistant starch (type III)
  • Resistant starch (type II)
  • Arabinoxylans
  • Stachyose (soy oligosaccharide)
  • Chitin
  • N-Acetyl-D-glucosamine
  • Acetate

  • ENDPRODUCTS
  • Butyrate [parent]
  • Lactate
  • Butyrate

  • INHIBITED BY
  • Low carbohydrate diet
  • High animal protein diet
  • Flaxseed [parent]
  • Epinephrine
  • Fructo-oligosaccharides
  • High meat diet

  • ENHANCED BY
  • Dietary fiber
  • Walnuts
  • β-Glucan
  • Resistant starch (type II)
  • Saccharomyces boulardii [parent]
  • Polymannuronic acid
  • Arabinoxylans
  • N-Acetyl-D-glucosamine
  • Walnuts [parent]
  • Vitamin D
  • Dopamine

  • BIOTRANSFORMS
  • Linoleic acid (LA) [parent]
  • Linolenic acid (CLnA) [parent]
  • Trimethylamine [parent]

  • BIOTRANFORM
  • Trimethylamine-N-oxide (TMAO) [parent]
  • Trans-11 conjugate linoleic acid (CLA) [parent]
  • Cis-9 conjugate linoleic acid (CLA) [parent]
  • Cis-15 conjugate linolenic acids (CLnA) [parent]
  • Cis-9 conjugate linolenic acids (CLnA) [parent]
  • Trans-11 conjugate linolenic acids (CLnA) [parent]

  • ANTIBIOTIC RESISTANCE
  • Tetracycline (tetw)

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