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Oxalobacter formigenes

RANK: Species

TAXONOMY: Bacteria -> Proteobacteria -> Betaproteobacteria -> Burkholderiales -> Oxalobacteraceae -> Oxalobacter -> Oxalobacter formigenes

OVERVIEW:

'Oxalobacter formigenes' is an oxalate-degrading anaerobic bacterium that colonizes the large intestine of numerous vertebrates, including humans. O. formigenes and humans share a beneficial symbiosis. Quinolone, a broad-spectrum antibiotic, kills O. formigenes. If a person's gastrointestinal tract lacks this bacterium, and therefore lacks the primary source for the Oxalyl-CoA decarboxylase enzyme, then the GI tract cannot degrade dietary oxalates which on digestion get absorbed easily and after some Vit B6 modulated partial metabolical degradation in the body, is excreted in the kidney where it precipitates with calcium forming calcium oxalate kidney stones.[http://www.urologystone.com/CH18WhatsNew/2001AUA.html (interim reference, describes two other studies)] Synonyms : strain OxB, CIP 106513, ATCC 35274 Direct sub-taxa of Oxalobacter formigenes: Oxalobacter formigenes DSM 4420, Oxalobacter formigenes HOxBLS, Oxalobacter formigenes OXCC13 

This species has been identified as a resident in the human gastrointestinal tract based on the phylogenetic framework of its small subunit ribosomal RNA gene sequences.[PMC 4262072]

COGEM
COGEM released a comprehensive database of pathogenicity assessment of around 2575 bacterial species in 2011. The database ranks the pathogenicity of species on a scale of 1 to 4. Oxalobacter formigenes ranks on this scale:


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Pathogen
Dysbiosis associated
Flora/ commensal
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Probiotic
Leanness
Obesity
Skin microbiome
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Vaginal microbiome
Butyrate producer
Catalase producer
Histamine producer
Food fermenter
Amylolytic
Propionate producer
Nitrifying
Biofilm producer
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