The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. The mechanistic target of rapamycin, also known as MTOR, is a protein that in humans is encoded by the MTOR gene. MTOR regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. The MTOR signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration. It is hypothesized that some dietary regimes, like caloric restriction and methionine restriction, cause lifespan extension by decreasing MTOR activity. Decreased MTOR activity has been found to increase life span in animal studies.
ATXN-2 (Ataxin-2) negatively regulates mTOR.