MTOR

MECHANISTIC TARGET OF RAPAMYCIN (SERINE/THREONINE KINASE)

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DESCRIPTION

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. The mechanistic target of rapamycin, also known as MTOR, is a protein that in humans is encoded by the MTOR gene. MTOR regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. The MTOR signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration. It is hypothesized that some dietary regimes, like caloric restriction and methionine restriction, cause lifespan extension by decreasing MTOR activity. Decreased MTOR activity has been found to increase life span in animal studies.

AGENTS ASSOCIATED WITH EXPRESSION OF MTOR
AGENT EVIDENCE ACTION PUBMED
ALPHA LIPOIC ACID
ALPHA LIPOIC ACID
2 ANTAGONIST 1
ASTRAGALUS (ASTRAGALUS MEMBRANACEUS)
ASTRAGALUS (ASTRAGALUS MEMBRANACEUS)
12 AGONIST 1
BERBERINE
BERBERINE
4 ANTAGONIST 1,2
CAFFEINE
CAFFEINE
1 ANTAGONIST 1
CANNABIDIOL
CANNABIDIOL
2 ANTAGONIST 1,2
CARYOPHYLLENE OXIDE
CARYOPHYLLENE OXIDE
1 ANTAGONIST 1
CINNAMON (CINNAMOMUM SPP.)
CINNAMON (CINNAMOMUM SPP.)
1 ANTAGONIST 1
CLOVE
CLOVE
1 ANTAGONIST 1
CORDYCEPS SINENSIS
CORDYCEPS SINENSIS
1 ANTAGONIST 1
CURCUMIN
CURCUMIN
7 ANTAGONIST 1,2,3,4
DIINDOLYLMETHANE
DIINDOLYLMETHANE
1 ANTAGONIST 1
DIOSGENIN
DIOSGENIN
1 ANTAGONIST 1
DMBT (BRARTEMICIN ANALOG)
DMBT (BRARTEMICIN ANALOG)
1 ANTAGONIST 1
EPIGALLOCATECHIN GALLATE
EPIGALLOCATECHIN GALLATE
4 ANTAGONIST 1,2
FISETIN
FISETIN
1 ANTAGONIST 1
GENISTEIN
GENISTEIN
1 ANTAGONIST 1
GINKGO (GINKGO BILOBA)
GINKGO (GINKGO BILOBA)
1 ANTAGONIST 1
GUAVA
GUAVA
1 ANTAGONIST 1
HONOKIOL
HONOKIOL
1 ANTAGONIST 1
KRILL OIL
KRILL OIL
1 AGONIST 1
MATRINE
MATRINE
3 ANTAGONIST 1
N-ACETYLCYSTEINE (NAC)
N-ACETYLCYSTEINE (NAC)
3 ANTAGONIST 1
OMEGA 3 FATTY ACIDS
OMEGA 3 FATTY ACIDS
5 MIXED 1,2
OREGANO
OREGANO
1 ANTAGONIST 1
PEPPER, BLACK
PEPPER, BLACK
1 ANTAGONIST 1
QUERCETIN
QUERCETIN
1 ANTAGONIST 1
RESVERATROL
RESVERATROL
1 ANTAGONIST 1
SKULLCAP (SCUTELLARIA BAICALENSIS)
SKULLCAP (SCUTELLARIA BAICALENSIS)
1 ANTAGONIST 1
TETRAHYDROBIOPTERIN (BH4)
TETRAHYDROBIOPTERIN (BH4)
2 UNDEFINED 1
TYROSINE
TYROSINE
2 UNDEFINED 1
WOGONIN
WOGONIN
2 ANTAGONIST 1
XIAO YAO SAN
XIAO YAO SAN
2 AGONIST 1
DISEASE ASSOCIATIONS WITH MTOR
DISEASE MAGNITUDE
SNPS ASSOCIATED WITH MTOR
REFERENCE ID MAGNITUDE ALLELE KEY CONCEPTS
rs17036350 2 T
rs2536 3 C AGING
rs1057079 4 T
rs11121691 2 T
ADVERSE DRUG REACTIONS ASSOCIATED WITH MTOR
DRUG SNP ADVERSE REACTION ALLELE PUBMED
TISSUE DISTRIBUTION OF MTOR
CATEGORY TISSUE
CARDIOVASCULAR SYSTEM HEART
DIGESTIVE SYSTEM LIVER
DIGESTIVE SYSTEM PANCREAS
IMMUNE SYSTEM T CELL
MUSCULO-SKELETAL SYSTEM SKELETAL MUSCLE
NERVOUS SYSTEM BRAIN
OBSTETRICAL PLACENTA
RESPIRATORY SYSTEM LUNG
URINARY SYSTEM KIDNEY
PATHWAY REGULATION ASSOCIATED WITH MTOR
PATHWAY EFFECT
CAUSAL ETIOLOGIC ASSOCIATIONS (INFERRED)MTOR
ETIOLOGY MAGNITUDE
METABOLOME ASSOCIATIONS: MTOR
HMDB ID METABOLITE