FUT2

FUCOSYLTRANSFERASE 2 (SECRETOR STATUS INCLUDED)

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DESCRIPTION

The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble blood group A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for the FUT2 gene: since there are two in-frame methionine initiation codons in the gene, two isoforms of the protein can be transcribed. They differ in the absence or presence of eleven amino acids N-terminal, but both the long and the short isoforms are reported to have the same catalytic activity. Homozygous FUT2 polymorphism leads ABH non-secretor status, and is associated with increased susceptibility to chronic diseases, gut microflora imbalance and less functional intestinal membrane. The Lewis blood group phenotypes of erythrocytes have been reported to change depending on the biological conditions such as pregnancy, alcoholic cirrhosis and pancreatitis, hydatid cysts, and cancer. The Lewis antigens are not synthesized in erythocyte progenitors. The glycosphingolipids that carry the antigenic Le-a or Le-b epitopes circulate in plasma bound to serum lipoproteins or in form of aqueous dispersions; they become adsorbed to the erythrocyte by a passive adsorption process. That is why their levels may vary; they are usually not detected on erythocytes of newborns but attain adult levels by the age of two. 

AGENTS ASSOCIATED WITH EXPRESSION OF FUT2
AGENT EVIDENCE ACTION PUBMED
BETA-GLUCANS
BETA-GLUCANS
4 AGONIST 1
BIFIDOBACTERIUM
BIFIDOBACTERIUM
9 AGONIST 1,2,3
ETHANOL
ETHANOL
3 ANTAGONIST 1
LEY/H
LEY/H
1 UNDEFINED 1
NON-SECRETOR DIETARY MODIFICATIONS
NON-SECRETOR DIETARY MODIFICATIONS
6 AGONIST 1,2
OLIGORIBONUCLEOTIDES (ORN)
OLIGORIBONUCLEOTIDES (ORN)
8 AGONIST 1,2
PEANUT AGGLUTININ (PNA)
PEANUT AGGLUTININ (PNA)
3 UNDEFINED 1
PROBIOTICS
PROBIOTICS
8 AGONIST 1,2,3
SECRETOR DIETARY MODIFICATIONS
SECRETOR DIETARY MODIFICATIONS
6 AGONIST 1,2
VITAMIN B-12 (COBALAMIN)
VITAMIN B-12 (COBALAMIN)
15 AGONIST 1,2,3,4,5
DISEASE ASSOCIATIONS WITH FUT2
SNPS ASSOCIATED WITH FUT2
REFERENCE ID MAGNITUDE ALLELE KEY CONCEPTS
rs602662 5 G B12 ABSORPTION, SERUM B6, B12 LEVELS, HIGER HOMOCYSTEINE, HELICOBACTER PYLORI, LIKELY NON-SECRETOR AA
rs1047781 3 T PARTIAL SECRETOR, LEWIS DOUBLE POSITIVE
rs492602 5 G B12, LINKED WITH NON-SECRETOR
rs601338 5 A SECRETOR STATUS, NOROVIRUS RESISTANCE
ADVERSE DRUG REACTIONS ASSOCIATED WITH FUT2
DRUG SNP ADVERSE REACTION ALLELE PUBMED
TISSUE DISTRIBUTION OF FUT2
CATEGORY TISSUE
DIGESTIVE SYSTEM COLON
DIGESTIVE SYSTEM INTESTINE
DIGESTIVE SYSTEM SALIVARY GLAND
FEMALE REPRODUCTIVE UTERUS
LACRIMAL APPARATUS LACRIMAL GLAND
SECRETIONS BREAST MILK
SECRETIONS SALIVA
SECRETIONS SEMEN
SECRETIONS TEAR
PATHWAY REGULATION ASSOCIATED WITH FUT2
PATHWAY EFFECT
CAUSAL ETIOLOGIC ASSOCIATIONS (INFERRED)FUT2
ETIOLOGY MAGNITUDE
ACETAMINOPHEN2
ACID-BASE IMBALANCE2
ACROMEGALY2
ACTINOID SERIES ELEMENTS2
ADENOCARCINOMA2
ADENOMATOUS POLYPOSIS COLI2
ADRENAL CORTEX HORMONES2
AIR POLLUTANTS2
AIR POLLUTANTS, ENVIRONMENTAL2
ALCOHOL-INDUCED DISORDERS, NERVOUS SYSTEM2
ALCOHOL-RELATED DISORDERS2
ALCOHOLIC BEVERAGES2
ALCOHOL DRINKING2
ALDEHYDES2
ALKADIENES2
AMINO ACIDS2
AMPHETAMINES2
ANALGESICS2
ANEMIA, HYPOCHROMIC2
ANEMIA, MEGALOBLASTIC2
ANGIOSPERMS2
ANISOLES2
ANTI-ASTHMATIC AGENTS2
ANTI-BACTERIAL AGENTS2
ANTI-INFECTIVE AGENTS2
ANTI-INFLAMMATORY AGENTS2
ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL2
ANTICOAGULANTS2
ANTIMETABOLITES2
ANTINEOPLASTIC AGENTS2
ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS2
ANTIOXIDANTS2
ANTIRHEUMATIC AGENTS2
ARSENIC2
ARTERIOSCLEROSIS2
ARTHRITIS, RHEUMATOID2
ASBESTOS2
ASTHMA2
AUTOIMMUNE DISEASES2
AUTONOMIC NERVOUS SYSTEM DISEASES2
BACTERIAL PROTEINS2
BACTERIAL VACCINES2
BENZOPYRENES2
BILIARY TRACT DISEASES2
BLOOD PROTEIN DISORDERS2
BRONCHIECTASIS2
BURNS2
BUTYRIC ACIDS2
CALCIUM METABOLISM DISORDERS2
CARBOHYDRATES2
CARCINOGENS2
CARCINOID TUMOR2
CARCINOMA2
CARDIOVASCULAR AGENTS2
CATECHOLS2
CAUSTICS2
CHLORIDES2
CHLORINE COMPOUNDS2
CHOLECYSTECTOMY2
COCAINE2
COLITIS2
CONNECTIVE TISSUE DISEASES2
CORONARY DISEASE2
CRESOLS2
CYTOTOXINS2
DIABETES MELLITUS, EXPERIMENTAL2
DIALYSIS2
DIET2
DIETARY CARBOHYDRATES2
DIGESTIVE SYSTEM ABNORMALITIES2
DIGESTIVE SYSTEM SURGICAL PROCEDURES2
DIPHOSPHONATES2
DRY EYE SYNDROMES2
DUODENOGASTRIC REFLUX2
DYSPEPSIA2
ENDOSCOPY2
ENVIRONMENTAL EXPOSURE2
ENVIRONMENTAL POLLUTANTS2
ENZYME INHIBITORS2
EPINEPHRINE2
EPSTEIN-BARR VIRUS INFECTIONS2
ESOPHAGEAL DISEASES2
ESOPHAGEAL MOTILITY DISORDERS2
ESTROGENS2
ETHANOL2
ETHYLENE GLYCOLS2
FANCONI ANEMIA2
FLUOROURACIL2
FOOD ADDITIVES2
FOREIGN BODIES2
FRACTURES, BONE2
FURANS2
GASTRITIS2
GASTROENTEROSTOMY2
GASTROINTESTINAL AGENTS2
GASTROINTESTINAL DISEASES2
GASTROINTESTINAL NEOPLASMS2
GRAM-NEGATIVE BACTERIAL INFECTIONS2
GUANIDINES2
HEAD AND NECK NEOPLASMS2
HEARTBURN2
HEART DEFECTS, CONGENITAL2
HEAT2
HEMATOMA, SUBDURAL2
HEPATITIS C2
HERBICIDES2
HERPESVIRIDAE INFECTIONS2
HERPES SIMPLEX2
HISTAMINE ANTAGONISTS2
HIV INFECTIONS2
HORMONES2
HTLV-I INFECTIONS2
HYPERSENSITIVITY, IMMEDIATE2
HYPERTENSION2
HYPERTENSION, PORTAL2
IMIDAZOLES2
IMMOBILIZATION2
IMMUNE SYSTEM DISEASES2
IMMUNIZATION2
IMMUNOLOGIC DEFICIENCY SYNDROMES2
IMMUNOSUPPRESSIVE AGENTS2
INFLAMMATION2
INFLAMMATORY BOWEL DISEASES2
INTESTINAL DISEASES2
INTESTINAL DISEASES, PARASITIC2
IRON COMPOUNDS2
IRON METABOLISM DISORDERS2
ISOXAZOLES2
KIDNEY FAILURE2
KIDNEY TRANSPLANTATION2
LACTONES2
LARYNGEAL DISEASES2
LASER SURGERY2
LEUKEMIA, T-CELL, ACUTE2
LEUKOCYTOSIS2
LIPOPOLYSACCHARIDES2
LIVER CIRRHOSIS2
LIVER DISEASES2
LIVER DISEASES, ALCOHOLIC2
LYMPHOMA, B-CELL2
LYMPHOMA, LOW-GRADE2
LYMPHOPROLIFERATIVE DISORDERS2
MALABSORPTION SYNDROMES2
MEAT2
MENTAL DISORDERS2
METALS, HEAVY2
METALS, LIGHT2
METAPLASIA2
METHIONINE2
METHYLNITRONITROSOGUANIDINE2
MILK2
MITOMYCINS2
MORAXELLACEAE INFECTIONS2
MUTAGENS2
MYCOTOXINS2
NAPROXEN2
NERVOUS SYSTEM DISEASES2
NITRATES2
NITRITES2
NITROGEN COMPOUNDS2
NITROIMIDAZOLES2
NITROSAMINES2
NITROSOUREA COMPOUNDS2
NITROSO COMPOUNDS2
OBESITY2
OMEPRAZOLE2
ORGANIC CHEMICALS2
ORGANOMETALLIC COMPOUNDS2
OSTOMY2
PANCREATITIS2
PARANEOPLASTIC ENDOCRINE SYNDROMES2
PEPTIC ULCER2
PEPTIDES, CYCLIC2
PESTICIDES2
PHARMACEUTICAL PREPARATIONS2
PHENYLACETATES2
PHENYLPROPIONATES2
PHYSICAL CONDITIONING, ANIMAL2
PLANT EXTRACTS2
PLATELET AGGREGATION INHIBITORS2
PLATINUM COMPOUNDS2
POLYPS2
POLYSACCHARIDES2
PREDNISOLONE2
PRESERVATION, BIOLOGICAL2
PROPANOLS2
PROSTAGLANDINS E, SYNTHETIC2
PROTON PUMPS2
PTERIDIUM2
PYRIDINES2
QUATERNARY AMMONIUM COMPOUNDS2
RADIATION INJURIES2
RADIOTHERAPY2
RADON2
RENAL DIALYSIS2
RHEUMATIC DISEASES2
SALICYLIC ACIDS2
SEAFOOD2
SEROTONIN2
SMOKE2
SMOKING2
SODIUM, DIETARY2
SODIUM CHLORIDE2
SOLANACEOUS ALKALOIDS2
SOLVENTS2
SOYBEANS2
STOMACH DISEASES2
STRESS2
STRESS, PSYCHOLOGICAL2
SUBSTANCE WITHDRAWAL SYNDROME2
SULFONAMIDES2
SULFONES2
TERPENES2
THIAZINES2
THIAZOLES2
THORACIC INJURIES2
THORACIC SURGICAL PROCEDURES2
TOBACCO2
TRANSITION ELEMENTS2
TRANSPLANTATION2
TRIAZINES2
TRIAZOLES2
VEGETABLES2
VITAMIN B 12 DEFICIENCY2
WATER-ELECTROLYTE IMBALANCE2
WATER POLLUTANTS2
WOUNDS AND INJURIES2
XANTHOMATOSIS2
XANTHONES2
XEROSTOMIA2
METABOLOME ASSOCIATIONS: FUT2
HMDB ID METABOLITE