MAOB

MONOAMINE OXIDASE B

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DESCRIPTION

The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine.

AGENTS ASSOCIATED WITH EXPRESSION OF MAOB
AGENT EVIDENCE ACTION PUBMED
7-ETHYL-8-METHYLFLAVIN
7-ETHYL-8-METHYLFLAVIN
2 UNDEFINED 1
ACORUS TATARINOWII
ACORUS TATARINOWII
1 ANTAGONIST 1
ASHWAGANDHA (WITHANIA SOMNIFERA)
ASHWAGANDHA (WITHANIA SOMNIFERA)
2 AGONIST 1
BERBERINE
BERBERINE
3 ANTAGONIST 1,2
COMFREY (SYMPHYTUM OFFICINALIS)
COMFREY (SYMPHYTUM OFFICINALIS)
1 ANTAGONIST 1
CURCUMIN
CURCUMIN
7 ANTAGONIST 1,2,3
CYAMOPSIS PSORALIOIDES
CYAMOPSIS PSORALIOIDES
1 ANTAGONIST 1
DOPAMINE
DOPAMINE
1 UNDEFINED 1
ECLIPTA PROSTRATA
ECLIPTA PROSTRATA
1 ANTAGONIST 1
ESTRADIOL
ESTRADIOL
4 ANTAGONIST 1,2
EUGENOL
EUGENOL
1 ANTAGONIST 1
GENTIAN
GENTIAN
1 ANTAGONIST 1
GREEN TEA, KUKICHA, BANCHA
GREEN TEA, KUKICHA, BANCHA
1 ANTAGONIST 1
GUAIACOL
GUAIACOL
2 ANTAGONIST 1
IRON
IRON
4 AGONIST 1,2
KAVA KAVA (PIPER METHYSTICUM)
KAVA KAVA (PIPER METHYSTICUM)
1 ANTAGONIST 1
LICORICE (GLYCYRRHIZA GLABRA)
LICORICE (GLYCYRRHIZA GLABRA)
1 ANTAGONIST 1
LITHIUM OROTATE
LITHIUM OROTATE
3 AGONIST 1
PASSIONFLOWER (PASSIFLORA INCARNATA)
PASSIONFLOWER (PASSIFLORA INCARNATA)
4 ANTAGONIST 1
PHELLODENDRON AMURENSE
PHELLODENDRON AMURENSE
1 ANTAGONIST 1
PIPERINE
PIPERINE
1 ANTAGONIST 1
PROGESTERONE
PROGESTERONE
2 AGONIST 1
PSORALEA CORYLIFOLIA SEED
PSORALEA CORYLIFOLIA SEED
1 ANTAGONIST 1
PTEROSTILBENE
PTEROSTILBENE
1 ANTAGONIST 1
RHODIOLA ROSEA
RHODIOLA ROSEA
1 ANTAGONIST 1
SKULLCAP (SCUTELLARIA BAICALENSIS)
SKULLCAP (SCUTELLARIA BAICALENSIS)
1 ANTAGONIST 1
TESTOSTERONE
TESTOSTERONE
1 ANTAGONIST 1
TURMERIC
TURMERIC
1 ANTAGONIST 1
VITAMIN B-1 (THIAMINE)
VITAMIN B-1 (THIAMINE)
3 AGONIST 1
VITAMIN B-12 (COBALAMIN)
VITAMIN B-12 (COBALAMIN)
3 ANTAGONIST 1
VITAMIN B-2 (RIBOFLAVIN)
VITAMIN B-2 (RIBOFLAVIN)
9 AGONIST 1,2,3,4,5,6
WILD INDIGO (BAPTISIA SPP.)
WILD INDIGO (BAPTISIA SPP.)
1 ANTAGONIST 1
DISEASE ASSOCIATIONS WITH MAOB
DISEASE MAGNITUDE
BULIMIA 1
PARKINSON DISEASE 3
SNPS ASSOCIATED WITH MAOB
REFERENCE ID MAGNITUDE ALLELE KEY CONCEPTS
rs5905512 3 G SCHIZOPHRENIA, PSYCHOSIS, MHPG CONCENTRATIONS, X-LINKED
rs1799836 6 C REDUCED BRAIN MAOB ACTIVITY, ANGER AND AGGRESSION IN SUICIDAL MALE PATIENTS, ADHD, PARKINSON DISEASE, SCHIZOPHRENIA
rs2283729 6 A AGREEABLENESS, X-LINKED
ADVERSE DRUG REACTIONS ASSOCIATED WITH MAOB
DRUG SNP ADVERSE REACTION ALLELE PUBMED
TISSUE DISTRIBUTION OF MAOB
CATEGORY TISSUE
CARDIOVASCULAR SYSTEM CARDIOMYOCYTE
CARDIOVASCULAR SYSTEM PLATELET
DIGESTIVE SYSTEM DUODENUM
DIGESTIVE SYSTEM ENTEROCYTE
DIGESTIVE SYSTEM HEPATOCYTE
DIGESTIVE SYSTEM PANCREAS
ENDOCRINE SYSTEM ADRENAL GLAND
ENDOCRINE SYSTEM PITUITARY GLAND
HEMATOLOGIC SYSTEM SPLEEN
MUSCULO-SKELETAL SYSTEM SMOOTH MUSCLE
NERVOUS SYSTEM EPENDYMAL CELL
NERVOUS SYSTEM FRONTAL CORTEX
RESPIRATORY SYSTEM LUNG
URINARY SYSTEM LOOP OF HENLE
PATHWAY REGULATION ASSOCIATED WITH MAOB
PATHWAY EFFECT
CAUSAL ETIOLOGIC ASSOCIATIONS (INFERRED)MAOB
ETIOLOGY MAGNITUDE
AIR POLLUTANTS2
ALCOHOL-RELATED DISORDERS2
ALCOHOL DRINKING2
AMINO ACIDS, DIAMINO2
AMINO ACID METABOLISM, INBORN ERRORS2
AMPHETAMINES2
ANEURYSM2
ANGIOSPERMS2
ANTACIDS2
ANTIFUNGAL AGENTS2
ANXIETY DISORDERS2
BONE MARROW TRANSPLANTATION2
BRAIN ISCHEMIA2
BRAIN NEOPLASMS2
CALCIUM METABOLISM DISORDERS2
CAROTID ARTERY DISEASES2
CATECHOLAMINES2
CENTRAL NERVOUS SYSTEM AGENTS2
CENTRAL NERVOUS SYSTEM CYSTS2
CENTRAL NERVOUS SYSTEM STIMULANTS2
CEREBRAL ARTERIAL DISEASES2
CEREBRAL HEMORRHAGE2
CEREBRAL INFARCTION2
CEREBROVASCULAR ACCIDENT2
CEREBROVASCULAR DISORDERS2
CHROMOSOME DISORDERS2
CONSTIPATION2
CRANIOCEREBRAL TRAUMA2
CYSTEINE2
CYSTICERCOSIS2
CYSTS2
DEGLUTITION DISORDERS2
DEMENTIA2
DEMYELINATING DISEASES2
DEPRESSIVE DISORDER2
DIABETES MELLITUS, TYPE 12
DIET2
DIETARY FATS2
DIET THERAPY2
DIHYDROXYPHENYLALANINE2
EATING DISORDERS2
ENCEPHALITIS2
ENCEPHALITIS, ARBOVIRUS2
ENDOTOXINS2
ENVIRONMENTAL EXPOSURE2
ENVIRONMENTAL POLLUTANTS2
ENZYME INHIBITORS2
FRUIT2
GASTROENTERITIS2
GASTROINTESTINAL AGENTS2
GAS POISONING2
GRAM-NEGATIVE BACTERIAL INFECTIONS2
HEMATOMA, SUBDURAL2
HERBICIDES2
HEREDITARY MOTOR AND SENSORY NEUROPATHIES2
HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS2
HISTAMINE ANTAGONISTS2
HYPOPARATHYROIDISM2
INTERFERON-ALPHA2
INTRACRANIAL ARTERIOSCLEROSIS2
IRON COMPOUNDS2
ISOFLAVONES2
ISOQUINOLINES2
LIVER CIRRHOSIS2
LUPUS ERYTHEMATOSUS, SYSTEMIC2
LYMPHOMA, B-CELL2
MACROLIDES2
MENINGEAL NEOPLASMS2
MENINGOENCEPHALITIS2
MENTAL RETARDATION2
METALS2
METALS, HEAVY2
METALS, LIGHT2
MITOCHONDRIAL DISEASES2
MOVEMENT DISORDERS2
MULTIPLE SCLEROSIS2
NEOPLASMS, VASCULAR TISSUE2
NEURODEGENERATIVE DISEASES2
NEUROTOXINS2
NEUROTRANSMITTER UPTAKE INHIBITORS2
NOCARDIA INFECTIONS2
OBESITY2
ORTHOMYXOVIRIDAE INFECTIONS2
OXIDOPAMINE2
PARKINSONIAN DISORDERS2
PARKINSON DISEASE, SECONDARY2
PENTANOIC ACIDS2
PESTICIDES2
PHARMACEUTICAL PREPARATIONS2
POLIOMYELITIS2
PROPYLAMINES2
PSYCHOTROPIC DRUGS2
PYRIDINES2
PYRIDINIUM COMPOUNDS2
PYRIMIDINONES2
RESPIRATORY TRACT INFECTIONS2
SENSATION DISORDERS2
SEROTONIN AGENTS2
SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL2
SKULL NEOPLASMS2
SMOKING2
SOLANACEOUS ALKALOIDS2
SOLVENTS2
STRESS2
STRESS, PSYCHOLOGICAL2
SUBSTANCE-RELATED DISORDERS2
TETANUS TOXOID2
THIAZOLES2
THORACIC OUTLET SYNDROME2
TRANQUILIZING AGENTS2
TRANSITION ELEMENTS2
VASCULAR DISEASES2
VITAMIN B DEFICIENCY2
VITAMIN D DEFICIENCY2
WATER-ELECTROLYTE IMBALANCE2
XANTHINES2
METABOLOME ASSOCIATIONS: MAOB
HMDB ID METABOLITE
HMDB04077 4,6-DIHYDROXYQUINOLINE
HMDB00022 3-METHOXYTYRAMINE
HMDB00259 SEROTONIN
HMDB02064 N-ACETYLPUTRESCINE
HMDB00303 TRYPTAMINE
HMDB03791 3,4-DIHYDROXYPHENYLACETALDEHYDE
HMDB01490 VANYLGLYCOL
HMDB02017 BENZENEETHANAMINE
HMDB01190 INDOLEACETALDEHYDE
HMDB00068 EPINEPHRINE
HMDB05037 SUMATRIPTAN
HMDB04095 5-METHOXYTRYPTAMINE
HMDB00164 METHYLAMINE