MTHFR

METHYLENETETRAHYDROFOLATE REDUCTASE (NAD(P)H)

CIRCUITS allows you to navigate using the protein-protein interaction (PPI) network. Red nodes indicate afferent (predecessor) PPI genes. Click on a PPI gene to navigate to that page. Gray nodes indicate metabolites and substrates (opens popup with minimal information). Use the search box for look for specific genes.

DESCRIPTION

The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine (HCy) remethylation to methionine, in the rate-limiting step of the methyl cycle. Methylene tetrahydrofolate reductase (MTHFR) is a highly polymorphic gene, and genetic variation influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.

MTHFR contains a bound flavin cofactor and uses NAD(P)H as the reducing agent. 5,10-methylene tetrahydrofolate is used to convert dUMP to dTMP for de novo thymidine synthesis.

5-methyltetrahydrofolate is used to convert HCy (a potentially toxic amino acid) to methionine by the enzyme methionine synthase. Note that homocysteine can also be converted to methionine by the folate-independent enzyme betaine-homocysteine methyltransferase (BHMT).

MTHFR is upstream to phase II detoxification. Lower MTHFR enzyme activity results in lower levels of methylated folate, leading to elevated homocysteine (HCy). This in turn places a burden on Cystathionine beta synthase (CBS), which is used for HCy reduction. If CBS gets depleted due to HCy burden and consequent lack of substrate (SAMe, vitamin B6), this could lead to lower sulfate levels for use in phase II pathways.

AGENTS ASSOCIATED WITH EXPRESSION OF MTHFR
AGENT EVIDENCE ACTION PUBMED
5-FORMYL-TETRAHYDROFOLATE
5-FORMYL-TETRAHYDROFOLATE
9 AGONIST 1,2,3
5-METHYLTETRAHYDROFOLATE
5-METHYLTETRAHYDROFOLATE
9 AGONIST 1,2,3
ADENOSYL COBALAMIN
ADENOSYL COBALAMIN
3 AGONIST 1
ADENOSYLMETHIONINE
ADENOSYLMETHIONINE
1 ANTAGONIST 1
ALPHA-LINOLENIC ACID ALA
ALPHA-LINOLENIC ACID ALA
3 AGONIST 1,2
BETAINE
BETAINE
15 AGONIST 1,2,3,4,5
CHELATION
CHELATION
3 AGONIST 1
DOCOSAHEXAENOIC ACID (DHA)
DOCOSAHEXAENOIC ACID (DHA)
3 AGONIST 1,2
EICOSAPENTAENOIC ACID (EPA)
EICOSAPENTAENOIC ACID (EPA)
2 AGONIST 1
FOLATE-RICH DIET
FOLATE-RICH DIET
6 AGONIST 1,2
FOLINIC ACID
FOLINIC ACID
24 AGONIST 1,2,3,4,5,6,7,8
LINOLEIC ACID
LINOLEIC ACID
2 AGONIST 1
METHIONINE
METHIONINE
12 AGONIST 1,2,3,4
MULTIVITAMIN
MULTIVITAMIN
3 AGONIST 1
NICOTINAMIDE ADENINE DINUCLEOTIDE NADH
NICOTINAMIDE ADENINE DINUCLEOTIDE NADH
3 AGONIST 1
OLEIC ACID
OLEIC ACID
2 ANTAGONIST 1
OMEGA 3 FATTY ACIDS
OMEGA 3 FATTY ACIDS
2 AGONIST 1
OMEGA 6 FATTY ACIDS
OMEGA 6 FATTY ACIDS
2 ANTAGONIST 1
RIBOFLAVIN 5' PHOSPHATE
RIBOFLAVIN 5' PHOSPHATE
11 AGONIST 1,2,3,4
SULFASALAZINE
SULFASALAZINE
1 ANTAGONIST 1
TETRAHYDROFOLATE
TETRAHYDROFOLATE
3 AGONIST 1
UNMETABOLIZED FOLIC ACID
UNMETABOLIZED FOLIC ACID
2 ANTAGONIST 1
VITAMIN B-12 (COBALAMIN)
VITAMIN B-12 (COBALAMIN)
24 AGONIST 1,2,3,4,5,6,7,8
VITAMIN B-2 (RIBOFLAVIN)
VITAMIN B-2 (RIBOFLAVIN)
19 AGONIST 1,2,3,4,5,6,7
VITAMIN B-6 (PYRIDOXINE)
VITAMIN B-6 (PYRIDOXINE)
9 AGONIST 1,2,3
VITAMIN B-9 (FOLIC ACID)
VITAMIN B-9 (FOLIC ACID)
39 UNDEFINED 1,2,3,4,5,6,7,8,9,10,11,12,13
DISEASE ASSOCIATIONS WITH MTHFR
DISEASE MAGNITUDE
ABORTION, HABITUAL 1
ABRUPTIO PLACENTAE 1
ACUTE DISEASE 1
ADENOCARCINOMA 1
ALBUMINURIA 1
ALZHEIMER DISEASE 1
AORTIC ANEURYSM, ABDOMINAL 1
ARTERIOSCLEROSIS 3
ARTHRITIS, RHEUMATOID 1
BRAIN ISCHEMIA 1
BREAST NEOPLASMS 1
CARCINOMA, SQUAMOUS CELL 1
CARDIOVASCULAR DISEASES 2
CAROTID ARTERY DISEASES 3
CEREBRAL HEMORRHAGE 1
CEREBROVASCULAR ACCIDENT 1
CEREBROVASCULAR DISORDERS 1
COLORECTAL NEOPLASMS 1
CORONARY ARTERIOSCLEROSIS 2
CORONARY DISEASE 1
DIABETES MELLITUS, TYPE 1 1
DIABETES MELLITUS, TYPE 2 4
DIABETIC ANGIOPATHIES 1
DIABETIC NEPHROPATHIES 3
ESOPHAGEAL NEOPLASMS 1
FETAL GROWTH RETARDATION 1
FOLIC ACID DEFICIENCY 2
FOREARM INJURIES 1
FRACTURES, BONE 1
GASTROINTESTINAL NEOPLASMS 1
GENETIC PREDISPOSITION TO DISEASE 16
HEART DEFECTS, CONGENITAL 1
HIP FRACTURES 1
HYPERHOMOCYSTEINEMIA 2
HYPERTENSION 1
INTRACRANIAL THROMBOSIS 1
KIDNEY FAILURE, CHRONIC 1
LEUKEMIA 1
LUNG NEOPLASMS 1
MIGRAINE DISORDERS 1
MYOCARDIAL INFARCTION 2
NEURAL TUBE DEFECTS 5
OSTEOPOROSIS, POSTMENOPAUSAL 2
PAPOVAVIRIDAE INFECTIONS 1
PRE-ECLAMPSIA 1
PRECANCEROUS CONDITIONS 1
PREGNANCY COMPLICATIONS 1
STOMACH NEOPLASMS 1
THROMBOEMBOLISM 1
THROMBOPHLEBITIS 1
TUMOR VIRUS INFECTIONS 1
UTERINE CERVICAL NEOPLASMS 1
VASCULAR DISEASES 1
SNPS ASSOCIATED WITH MTHFR
REFERENCE ID MAGNITUDE ALLELE KEY CONCEPTS
rs1801133 8 A HOMOCYSTEINE, AUTOIMMUNITY, CANCER MIGRAINE HEADACHE
rs13306560 1 T
rs17367504 6 G HYPERTENSION, ORTHOSTATIC HYPERTENSION, RESPONSE TO BETA BLOCKERS
rs3737964 1 T
rs17037396 1 T
rs1476413 1 T
rs4846049 1 T
rs2274976 5 T
rs2066470 7 T HOMOCYSTEINE, CARDIOVASCULAR RISK
rs1999594 7 A FOLATE TRANSPORTER, LOW SERUM FOLATE, HIGH HOMOCYSTEINE
rs4846048 1 G
rs12121543 1 A
rs13306561 1 G
rs4846051 1 G METHOTREXATE TOXICITY
rs1801131 7 G NEUROTRANSMITTER SYNTHESIS
rs17037390 1 A
ADVERSE DRUG REACTIONS ASSOCIATED WITH MTHFR
DRUG SNP ADVERSE REACTION ALLELE PUBMED
METHOTREXATE rs1801133MUCOSITIS, HEPATIC TOXICITY, THROMBOCYTOPENIA, ALOPECIAA1
TISSUE DISTRIBUTION OF MTHFR
CATEGORY TISSUE
CARDIOVASCULAR SYSTEM HEART
DIGESTIVE SYSTEM COLON
DIGESTIVE SYSTEM INTESTINE
DIGESTIVE SYSTEM LIVER
DIGESTIVE SYSTEM STOMACH
HEMATOLOGIC SYSTEM SPLEEN
MALE REPRODUCTIVE TESTIS
MUSCULO-SKELETAL SYSTEM MUSCLE
NERVOUS SYSTEM BRAIN
OBSTETRICAL PLACENTA
RESPIRATORY SYSTEM LUNG
URINARY SYSTEM KIDNEY
PATHWAY REGULATION ASSOCIATED WITH MTHFR
PATHWAY EFFECT
IL-4 SIGNALING PATHWAY UPREGULATION
CAUSAL ETIOLOGIC ASSOCIATIONS (INFERRED)MTHFR
ETIOLOGY MAGNITUDE
4-HYDROXYCOUMARINS2
4-NITROQUINOLINE-1-OXIDE2
6-MERCAPTOPURINE2
7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE2
ABDOMINAL INJURIES2
ABDOMINAL NEOPLASMS2
ABORTIFACIENT AGENTS2
ABSCESS2
ACCELERATION2
ACETAMIDES2
ACETAMINOPHEN2
ACETATES2
ACETAZOLAMIDE2
ACETIC ACIDS2
ACID-BASE IMBALANCE2
ACIDOSIS2
ACQUIRED IMMUNODEFICIENCY SYNDROME2
ACROMEGALY2
ACRYLAMIDES2
ACTINOID SERIES ELEMENTS2
ACTINOMYCETALES INFECTIONS2
ACTINOMYCOSIS2
ACUPUNCTURE THERAPY2
ACYCLOVIR2
ADENOCARCINOMA2
ADENOMA2
ADENOMATOUS POLYPOSIS COLI2
ADENOMATOUS POLYPS2
ADENOSINE2
ADRENALECTOMY2
ADRENAL CORTEX DISEASES2
ADRENAL CORTEX HORMONES2
ADRENAL CORTEX NEOPLASMS2
ADRENAL GLAND DISEASES2
ADRENAL GLAND NEOPLASMS2
ADRENAL INSUFFICIENCY2
ADRENERGIC AGENTS2
ADRENERGIC AGONISTS2
ADRENERGIC ANTAGONISTS2
ADRENOCORTICAL HYPERFUNCTION2
AFFECTIVE SYMPTOMS2
AFLATOXINS2
AGRANULOCYTOSIS2
AGROCHEMICALS2
AIR POLLUTANTS2
AIR POLLUTANTS, ENVIRONMENTAL2
AIR POLLUTION2
ALBUMINS2
ALCOHOL-INDUCED DISORDERS2
ALCOHOL-INDUCED DISORDERS, NERVOUS SYSTEM2
ALCOHOL-RELATED DISORDERS2
ALCOHOLIC BEVERAGES2
ALCOHOLS2
ALCOHOL DRINKING2
ALDEHYDES2
ALKADIENES2
ALKALOIDS2
ALKANES2
ALKYLATING AGENTS2
ALLOYS2
ALLYL COMPOUNDS2
ALOPECIA2
ALPHA-THALASSEMIA2
ALPHAVIRUS INFECTIONS2
ALPHA PARTICLES2
ALUMINUM COMPOUNDS2
ALUMINUM SILICATES2
AMIDINES2
AMINES2
AMINOCAPROIC ACIDS2
AMINOGLYCOSIDES2
AMINOPTERIN2
AMINOSALICYLIC ACIDS2
AMINO ACIDS2
AMINO ACIDS, DIAMINO2
AMINO ACID METABOLISM, INBORN ERRORS2
AMINO ALCOHOLS2
AMOXICILLIN2
AMPHETAMINE2
AMPHETAMINES2
AMYLOIDOSIS2
AMYLOIDOSIS, FAMILIAL2
AMYLOID BETA-PROTEIN2
AMYLOID NEUROPATHIES2
ANALGESIA2
ANALGESICS2
ANALGESICS, NON-NARCOTIC2
ANDROSTADIENES2
ANDROSTANOLS2
ANDROSTENES2
ANEMIA2
ANEMIA, HEMOLYTIC2
ANEMIA, HYPOCHROMIC2
ANEMIA, MEGALOBLASTIC2
ANEMIA, SICKLE CELL2
ANESTHESIA2
ANESTHESIA, EPIDURAL2
ANESTHESIA, GENERAL2
ANESTHETICS2
ANESTHETICS, GENERAL2
ANESTHETICS, INTRAVENOUS2
ANEURYSM2
ANEURYSM, DISSECTING2
ANEURYSM, RUPTURED2
ANGINA, UNSTABLE2
ANGINA PECTORIS2
ANGIODYSPLASIA2
ANGIOGENESIS INDUCING AGENTS2
ANGIOGRAPHY2
ANGIOMATOSIS2
ANGIOPLASTY2
ANGIOPLASTY, BALLOON2
ANGIOSPERMS2
ANGIOTENSIN II2
ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS2
ANILIDES2
ANILINE COMPOUNDS2
ANIONS2
ANISOLES2
ANKYLOSIS2
ANOXIA2
ANTACIDS2
ANTHRACYCLINES2
ANTHRAQUINONES2
ANTI-ASTHMATIC AGENTS2
ANTI-BACTERIAL AGENTS2
ANTI-DYSKINESIA AGENTS2
ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE2
ANTI-HIV AGENTS2
ANTI-INFECTIVE AGENTS2
ANTI-INFLAMMATORY AGENTS2
ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL2
ANTI-OBESITY AGENTS2
ANTI-RETROVIRAL AGENTS2
ANTIBODIES2
ANTIBODIES, ANTIPHOSPHOLIPID2
ANTIBODIES, MONOCLONAL2
ANTICHOLESTEREMIC AGENTS2
ANTICOAGULANTS2
ANTIDEPRESSIVE AGENTS2
ANTIFUNGAL AGENTS2
ANTIGENS2
ANTIGENS, SURFACE2
ANTILIPEMIC AGENTS2
ANTIMETABOLITES2
ANTINEOPLASTIC AGENTS2
ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS2
ANTIOXIDANTS2
ANTIPLATYHELMINTIC AGENTS2
ANTIPROTOZOAL AGENTS2
ANTIRHEUMATIC AGENTS2
ANTISICKLING AGENTS2
ANTITHROMBINS2
ANTITUBERCULAR AGENTS2
ANTIVIRAL AGENTS2
ANXIETY2
ANXIETY DISORDERS2
AORTIC ANEURYSM2
AORTIC ARCH SYNDROMES2
AORTIC DISEASES2
AORTIC STENOSIS, SUPRAVALVULAR2
AORTIC VALVE STENOSIS2
APNEA2
ARACHIDONIC ACID2
ARECA2
ARGININE2
ARGIPRESSIN2
ARISTOLOCHIACEAE2
AROCLORS2
ARRHYTHMIA2
ARSENIC2
ARSENICALS2
ARTERIAL OCCLUSIVE DISEASES2
ARTERIOSCLEROSIS2
ARTERIOVENOUS MALFORMATIONS2
ARTERITIS2
ARTHRITIS2
ARTHRITIS, RHEUMATOID2
ARTHRODESIS2
ARTHROPOD VENOMS2
ASBESTOS2
ASBESTOS, AMPHIBOLE2
ASCORBIC ACID DEFICIENCY2
ASPARAGINASE2
ASPHYXIA NEONATORUM2
ASSISTED CIRCULATION2
ASTERACEAE2
ASTHMA2
ASTROCYTOMA2
ATHERECTOMY2
AUTOANTIBODIES2
AUTOIMMUNE DISEASES2
AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM2
AUTONOMIC NERVOUS SYSTEM DISEASES2
AVITAMINOSIS2
AZIDES2
BACTEREMIA2
BACTERIAL INFECTIONS2
BACTERIAL TOXINS2
BACTERIAL VACCINES2
BACTEROIDACEAE INFECTIONS2
BALLOON DILATATION2
BANDAGES2
BARBITURATES2
BAROTRAUMA2
BARTONELLA INFECTIONS2
BASAL GANGLIA CEREBROVASCULAR DISEASE2
BASAL GANGLIA DISEASES2
BASAL GANGLIA HEMORRHAGE2
BATHS2
BCG VACCINE2
BED REST2
BELLADONNA ALKALOIDS2
BENZ(A)ANTHRACENES2
BENZAMIDES2
BENZAMIDINES2
BENZENE DERIVATIVES2
BENZHYDRYL COMPOUNDS2
BENZIMIDAZOLES2
BENZODIAZEPINES2
BENZODIAZEPINONES2
BENZOFURANS2
BENZOPYRANS2
BENZOPYRENES2
BETAMETHASONE2
BICYCLO COMPOUNDS, HETEROCYCLIC2
BIGUANIDES2
BILIARY TRACT DISEASES2
BIOGENIC AMINES2
BIOLOGICAL PRODUCTS2
BIOLOGICAL RESPONSE MODIFIERS2
BIOLOGICAL THERAPY2
BIOPSY2
BIPHENYL COMPOUNDS2
BIRTH INJURIES2
BITES AND STINGS2
BLADDER DISEASES2
BLEOMYCIN2
BLOOD COAGULATION DISORDERS2
BLOOD COAGULATION DISORDERS, INHERITED2
BLOOD COAGULATION FACTORS2
BLOOD COMPONENT REMOVAL2
BLOOD COMPONENT TRANSFUSION2
BLOOD GROUP INCOMPATIBILITY2
BLOOD PLATELET DISORDERS2
BLOOD PRESSURE DETERMINATION2
BLOOD PROTEINS2
BLOOD PROTEIN DISORDERS2
BLOOD SPECIMEN COLLECTION2
BLOOD SUBSTITUTES2
BLOOD TRANSFUSION2
BONE DISEASES2
BONE DISEASES, DEVELOPMENTAL2
BONE DISEASES, INFECTIOUS2
BONE DISEASES, METABOLIC2
BONE MARROW DISEASES2
BONE MARROW TRANSPLANTATION2
BONE NEOPLASMS2
BONE RESORPTION2
BRAIN ABSCESS2
BRAIN CONCUSSION2
BRAIN DAMAGE, CHRONIC2
BRAIN DISEASES2
BRAIN DISEASES, METABOLIC, INBORN2
BRAIN INFARCTION2
BRAIN INJURIES2
BRAIN ISCHEMIA2
BRAIN NEOPLASMS2
BRAIN STEM INFARCTIONS2
BREAST DISEASES2
BREAST FEEDING2
BREAST NEOPLASMS2
BREATHING EXERCISES2
BRONCHIAL DISEASES2
BRONCHIECTASIS2
BRONCHITIS2
BRUXISM2
BUNYAVIRIDAE INFECTIONS2
BURNS2
BUTYLENE GLYCOLS2
BUTYRATES2
BUTYRIC ACIDS2
BUTYROPHENONES2
CACAO2
CADMIUM COMPOUNDS2
CALCINOSIS2
CALCIUM COMPOUNDS2
CALCIUM METABOLISM DISORDERS2
CALCIUM PHOSPHATES2
CALCULI2
CAMPTOTHECIN2
CANDIDIASIS2
CANDY2
CANNABINOIDS2
CANNABIS2
CARBAZOLES2
CARBOHYDRATES2
CARBON2
CARBONATES2
CARBON COMPOUNDS, INORGANIC2
CARBON DIOXIDE2
CARCINOGENS2
CARCINOID TUMOR2
CARCINOMA2
CARCINOMA IN SITU2
CARDENOLIDES2
CARDIAC GLYCOSIDES2
CARDIAC PACING, ARTIFICIAL2
CARDIAC SURGICAL PROCEDURES2
CARDIOMEGALY2
CARDIOMYOPATHIES2
CARDIOMYOPATHY, HYPERTROPHIC2
CARDIOVASCULAR ABNORMALITIES2
CARDIOVASCULAR AGENTS2
CARDIOVASCULAR DISEASES2
CARIOSTATIC AGENTS2
CAROTENOIDS2
CAROTID ARTERY DISEASES2
CAROTID ARTERY INJURIES2
CARRIER PROTEINS2
CARTILAGE DISEASES2
CASTRATION2
CATARACT EXTRACTION2
CATECHOLAMINES2
CATECHOLS2
CATHA2
CATHETERIZATION2
CATHETERIZATION, PERIPHERAL2
CAULOPHYLLUM2
CECAL DISEASES2
CELL TRANSPLANTATION2
CENTRAL NERVOUS SYSTEM AGENTS2
CENTRAL NERVOUS SYSTEM BACTERIAL INFECTIONS2
CENTRAL NERVOUS SYSTEM CYSTS2
CENTRAL NERVOUS SYSTEM DEPRESSANTS2
CENTRAL NERVOUS SYSTEM INFECTIONS2
CENTRAL NERVOUS SYSTEM NEOPLASMS2
CENTRAL NERVOUS SYSTEM PROTOZOAL INFECTIONS2
CENTRAL NERVOUS SYSTEM STIMULANTS2
CENTRAL NERVOUS SYSTEM VASCULAR MALFORMATIONS2
CEPHALOSPORINS2
CERAMICS2
CEREBELLAR DISEASES2
CEREBRAL AMYLOID ANGIOPATHY2
CEREBRAL ARTERIAL DISEASES2
CEREBRAL DECORTICATION2
CEREBRAL HEMORRHAGE2
CEREBRAL INFARCTION2
CEREBRAL VENTRICLE NEOPLASMS2
CEREBROSPINAL FLUID SHUNTS2
CEREBROVASCULAR ACCIDENT2
CEREBROVASCULAR DISORDERS2
CEREBROVASCULAR TRAUMA2
CHAGAS DISEASE2
CHEMOPREVENTION2
CHEST PAIN2
CHICKENPOX VACCINE2
CHIROPRACTIC2
CHLAMYDIACEAE INFECTIONS2
CHLAMYDIA INFECTIONS2
CHLAMYDOPHILA INFECTIONS2
CHLORAL HYDRATE2
CHLORAMBUCIL2
CHLORAMPHENICOL2
CHLORIDES2
CHLORINE COMPOUNDS2
CHLOROBENZENES2
CHLOROFLUOROCARBONS2
CHLOROPHENOLS2
CHLOROQUINE2
CHOLANGITIS2
CHOLECALCIFEROL2
CHOLECYSTECTOMY2
CHOLECYSTITIS2
CHOLECYSTOLITHIASIS2
CHOLEDOCHAL CYST2
CHOLELITHIASIS2
CHOLESTASIS2
CHOLESTASIS, INTRAHEPATIC2
CHOLESTEATOMA2
CHOLESTEROL2
CHOLESTEROL ESTER STORAGE DISEASE2
CHOLINERGIC AGENTS2
CHONDROMA2
CHONDROSARCOMA2
CHORIONIC GONADOTROPIN2
CHORISTOMA2
CHROMANS2
CHROMATES2
CHROMIUM COMPOUNDS2
CHROMOSOME DISORDERS2
CHRONOBIOLOGY DISORDERS2
CICATRIX2
CINNAMATES2
CIPROFLOXACIN2
CITRUS2
CLINICAL TRIALS2
CLOFIBRIC ACID2
CLONIDINE2
CLOSTRIDIUM INFECTIONS2
CLOTHING2
CLUSTER HEADACHE2
COAGULATION PROTEIN DISORDERS2
COAL2
COCAINE2
COCCIDIOSIS2
COCOS2
CODEINE2
COGNITION DISORDERS2
COLD2
COLECTOMY2
COLITIS2
COLLAGEN DISEASES2
COLONIC DISEASES2
COLONOSCOPY2
COLONY-STIMULATING FACTORS2
COLORECTAL NEOPLASMS2
COLORING AGENTS2
COMA2
COMPARTMENT SYNDROMES2
COMPLEMENTARY THERAPIES2
COMPLEMENT C1Q2
COMPLEX REGIONAL PAIN SYNDROMES2
CONJUNCTIVITIS2
CONNECTIVE TISSUE DISEASES2
CONSTIPATION2
CONTRACEPTION2
CONTRACEPTIVES, ORAL2
CONTRACEPTIVES, POSTCOITAL2
CONTRACEPTIVE AGENTS2
CONTRACEPTIVE AGENTS, FEMALE2
CONTRACEPTIVE DEVICES, MALE2
CONTRAST MEDIA2
CONVULSIVE THERAPY2
CORONARY ARTERY BYPASS2
CORONARY DISEASE2
CORONARY STENOSIS2
CORONARY VASOSPASM2
CORTICOTROPIN2
COSMETICS2
COSMIC RADIATION2
COXSACKIEVIRUS INFECTIONS2
CRANIAL IRRADIATION2
CRANIAL NERVE NEOPLASMS2
CRANIOCEREBRAL TRAUMA2
CRANIOFACIAL ABNORMALITIES2
CRANIOFACIAL DYSOSTOSIS2
CRANIOPHARYNGIOMA2
CRANIOSYNOSTOSES2
CRESOLS2
CROTALID VENOMS2
CRYOTHERAPY2
CRYPTOCOCCOSIS2
CULTURE MEDIA2
CYANATES2
CYCLOBUTANES2
CYCLOHEXANECARBOXYLIC ACIDS2
CYCLOHEXANES2
CYCLOHEXANOLS2
CYCLOPHOSPHAMIDE2
CYCLOPROPANES2
CYCLOSPORINS2
CYPROTERONE2
CYSTADENOCARCINOMA2
CYSTADENOMA2
CYSTICERCOSIS2
CYSTS2
CYTODIAGNOSIS2
CYTOMEGALOVIRUS INFECTIONS2
CYTOSINE2
CYTOTOXINS2
DAIRY PRODUCTS2
DAUNORUBICIN2
DECOMPRESSION2
DEFICIENCY DISEASES2
DELIVERY, OBSTETRIC2
DEMENTIA2
DEMENTIA, VASCULAR2
DEMYELINATING DISEASES2
DENERVATION2
DENTAL ALLOYS2
DENTAL BONDING2
DENTAL CARE2
DENTAL CEMENTS2
DENTAL DISINFECTANTS2
DENTAL IMPLANTATION2
DENTAL MATERIALS2
DENTAL PLAQUE2
DEOXYADENOSINES2
DEOXYCHOLIC ACID2
DEOXYGLUCOSE2
DEPRESSION2
DEPRESSIVE DISORDER2
DERMATITIS2
DERMATOLOGIC AGENTS2
DERMATOMYCOSES2
DEXAMETHASONE2
DEXTROCARDIA2
DEXTROMETHORPHAN2
DIABETES, GESTATIONAL2
DIABETES COMPLICATIONS2
DIABETES MELLITUS, EXPERIMENTAL2
DIABETES MELLITUS, TYPE 12
DIABETES MELLITUS, TYPE 22
DIABETIC ANGIOPATHIES2
DIABETIC NEUROPATHIES2
DIAGNOSTIC IMAGING2
DIALYSIS2
DIALYSIS SOLUTIONS2
DIARRHEA2
DIBENZAZEPINES2
DIBENZOCYCLOHEPTENES2
DIBENZOTHIEPINS2
DIDEOXYNUCLEOSIDES2
DIET2
DIET, VEGETARIAN2
DIETARY CARBOHYDRATES2
DIETARY FATS2
DIETARY FATS, UNSATURATED2
DIETARY PROTEINS2
DIETARY SUPPLEMENTS2
DIET THERAPY2
DIGESTIVE SYSTEM ABNORMALITIES2
DIGESTIVE SYSTEM SURGICAL PROCEDURES2
DIGITALIS GLYCOSIDES2
DIHYDROPYRIDINES2
DIHYDROXYCHOLECALCIFEROLS2
DIHYDROXYPHENYLALANINE2
DILATATION, PATHOLOGIC2
DILATATION AND CURETTAGE2
DIMETHYLHYDRAZINES2
DIOXINS2
DIOXOLES2
DIPEPTIDES2
DIPHOSPHONATES2
DIPHTHERIA TOXOID2
DIPYRONE2
DISACCHARIDES2
DISEASE SUSCEPTIBILITY2
DISINFECTANTS2
DISKECTOMY2
DISULFIDES2
DITIOCARB2
DIURETICS2
DIVERTICULITIS2
DIVERTICULUM2
DIVING2
DNA VIRUS INFECTIONS2
DOPAMINE AGENTS2
DOXORUBICIN2
DRAINAGE2
DRUG ERUPTIONS2
DRUG HYPERSENSITIVITY2
DRY EYE SYNDROMES2
DUODENOGASTRIC REFLUX2
DUST2
DWARFISM2
DYSKINESIAS2
DYSOSTOSES2
DYSTONIA2
EATING DISORDERS2
ECHINOCOCCOSIS2
ECLAMPSIA2
EDEMA2
EFLORNITHINE2
EGGS2
ELASTOMERS2
ELECTRICITY2
ELECTROMAGNETIC FIELDS2
EMBOLISM2
EMBOLIZATION, THERAPEUTIC2
EMERGENCY TREATMENT2
EMPHYSEMA2
EMPYEMA, PLEURAL2
EMULSIONS2
ENALAPRIL2
ENCEPHALITIS2
ENCEPHALITIS, VIRAL2
ENCEPHALOMYELITIS2
ENDARTERECTOMY2
ENDOCARDITIS2
ENDOCARDITIS, BACTERIAL2
ENDOCRINE GLAND NEOPLASMS2
ENDOCRINE SYSTEM DISEASES2
ENDOMETRIAL NEOPLASMS2
ENDOPEPTIDASES2
ENDOSCOPY2
ENDOTHELINS2
ENDOTOXINS2
ENTEROBACTERIACEAE INFECTIONS2
ENTEROTOXINS2
ENTEROVIRUS INFECTIONS2
ENVIRONMENTAL EXPOSURE2
ENVIRONMENTAL ILLNESS2
ENVIRONMENTAL POLLUTANTS2
ENVIRONMENTAL POLLUTION2
ENZYME INHIBITORS2
EOSINOPHILIA2
EPENDYMOMA2
EPHEDRA2
EPIDERMOLYSIS BULLOSA2
EPILEPSIES, PARTIAL2
EPILEPSY2
EPILEPSY, GENERALIZED2
EPINEPHRINE2
EPOPROSTENOL2
EPOXY COMPOUNDS2
EPSTEIN-BARR VIRUS INFECTIONS2
ERGOCALCIFEROLS2
ERGOLINES2
ERGONOVINE2
ERGOTAMINES2
ERGOT ALKALOIDS2
ERYTHEMA NODOSUM2
ERYTHROBLASTOSIS, FETAL2
ERYTHROMYCIN2
ERYTHROPOIETIN2
ERYTHROPOIETIN, RECOMBINANT2
ESCHERICHIA COLI INFECTIONS2
ESOPHAGEAL DISEASES2
ESOPHAGEAL MOTILITY DISORDERS2
ESOPHAGITIS2
ESTRADIOL2
ESTRADIOL CONGENERS2
ESTROGENS2
ESTROGENS, NON-STEROIDAL2
ESTROGEN RECEPTOR MODULATORS2
ETHANOL2
ETHANOLAMINES2
ETHINYL ESTRADIOL2
ETHIONINE2
ETHYLENE GLYCOLS2
EUPHORBIACEAE2
EXOPHTHALMOS2
EXOSTOSES2
EXTRACORPOREAL CIRCULATION2
EXTRACTION, OBSTETRICAL2
EYE HEMORRHAGE2
FABACEAE2
FACIAL INJURIES2
FACTOR VII2
FANCONI ANEMIA2
FATIGUE2
FATS, UNSATURATED2
FATTY ACIDS2
FATTY ACIDS, ESSENTIAL2
FATTY ACIDS, MONOUNSATURATED2
FATTY ACIDS, OMEGA-32
FATTY ACIDS, OMEGA-62
FATTY ACIDS, UNSATURATED2
FATTY LIVER2
FEMORAL FRACTURES2
FEMUR HEAD NECROSIS2
FENFLURAMINE2
FENTANYL2
FERRIC COMPOUNDS2
FERTILITY AGENTS2
FERTILIZATION IN VITRO2
FETAL HYPOXIA2
FEVER2
FIBROBLAST GROWTH FACTOR 22
FIBROMA2
FIBROSIS2
FIBROUS DYSPLASIA OF BONE2
FISTULA2
FLAVONOIDS2
FLAVORING AGENTS2
FLOXURIDINE2
FLUORENES2
FLUORESCEINS2
FLUORIDATION2
FLUORIDES2
FLUOROURACIL2
FOCAL INFECTION2
FOLIC ACID2
FOLLICLE STIMULATING HORMONE2
FOOD2
FOOD, FORMULATED2
FOOD, FORTIFIED2
FOOD ADDITIVES2
FOOD HYPERSENSITIVITY2
FOOD POISONING2
FOOT ULCER2
FOREIGN-BODY REACTION2
FOREIGN BODIES2
FORMALDEHYDE2
FORMIC ACIDS2
FOSCARNET2
FRACTURES, BONE2
FREE RADICALS2
FURANS2
FUSOBACTERIUM INFECTIONS2
GABA AGENTS2
GASTRITIS2
GASTROENTERITIS2
GASTROENTEROSTOMY2
GASTROINTESTINAL AGENTS2
GASTROINTESTINAL DISEASES2
GASTROINTESTINAL HEMORRHAGE2
GASTROINTESTINAL NEOPLASMS2
GAS POISONING2
GAUCHER DISEASE2
GELATIN2
GENETIC DISEASES, INBORN2
GENETIC DISEASES, X-LINKED2
GENITAL DISEASES, FEMALE2
GENITAL DISEASES, MALE2
GENITAL NEOPLASMS, FEMALE2
GENITAL NEOPLASMS, MALE2
GESTATIONAL TROPHOBLASTIC NEOPLASMS2
GINGER2
GINGIVAL DISEASES2
GINGIVITIS2
GINKGO BILOBA2
GLAUCOMA2
GLIOMA2
GLOMERULONEPHRITIS2
GLUCOSE TOLERANCE TEST2
GLUCOSIDES2
GLUTAMIC ACID2
GLYCERIDES2
GLYCEROL2
GLYCOGEN STORAGE DISEASE2
GLYCOPROTEINS2
GLYCYRRHETINIC ACID2
GLYOXAL2
GOITER2
GOLD COMPOUNDS2
GOLD SODIUM THIOMALATE2
GONADAL DISORDERS2
GONADAL DYSGENESIS2
GONADAL STEROID HORMONES2
GONADORELIN2
GONADOTROPINS2
GOUT2
GRAFT OCCLUSION, VASCULAR2
GRAFT REJECTION2
GRAM-NEGATIVE BACTERIAL INFECTIONS2
GRAM-POSITIVE BACTERIAL INFECTIONS2
GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR2
GRANULOCYTE COLONY-STIMULATING FACTOR2
GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT2
GRANULOMA2
GRAVITY, ALTERED2
GROWTH DISORDERS2
GROWTH HORMONE2
GROWTH INHIBITORS2
GUANIDINES2
GUILLAIN-BARRE SYNDROME2
GYNECOLOGIC SURGICAL PROCEDURES2
HAIR DISEASES2
HAIR PREPARATIONS2
HAMARTOMA2
HANTAVIRUS INFECTIONS2
HAZARDOUS WASTE2
HEAD AND NECK NEOPLASMS2
HEARING LOSS, SENSORINEURAL2
HEART, ARTIFICIAL2
HEARTBURN2
HEART BYPASS, RIGHT2
HEART CATHETERIZATION2
HEART DEFECTS, CONGENITAL2
HEART DISEASES2
HEART FAILURE, CONGESTIVE2
HEART RUPTURE, POST-INFARCTION2
HEART SEPTAL DEFECTS2
HEART SEPTAL DEFECTS, ATRIAL2
HEART VALVE DISEASES2
HEAT2
HEAT STRESS DISORDERS2
HEAT STROKE2
HEAVY CHAIN DISEASE2
HELIUM2
HELLP SYNDROME2
HEMANGIOENDOTHELIOMA2
HEMANGIOMA2
HEMANGIOMA, CAPILLARY2
HEMANGIOMA, CAVERNOUS2
HEMATOLOGIC DISEASES2
HEMATOMA2
HEMATOMA, SUBDURAL2
HEMATOPOIETIC CELL GROWTH FACTORS2
HEME2
HEMODILUTION2
HEMOFILTRATION2
HEMOGLOBINOPATHIES2
HEMOGLOBINS2
HEMORRHAGE2
HEMORRHAGIC DISORDERS2
HEMORRHAGIC FEVERS, VIRAL2
HEMOSTATICS2
HEPARIN2
HEPARIN, LOW-MOLECULAR-WEIGHT2
HEPATITIS2
HEPATITIS, CHRONIC2
HEPATITIS, VIRAL, HUMAN2
HEPATITIS B2
HEPATITIS C2
HEPTACHLOR EPOXIDE2
HERBICIDES2
HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES2
HEREDODEGENERATIVE DISORDERS, NERVOUS SYSTEM2
HERNIA, ABDOMINAL2
HERNIA, VENTRAL2
HERPESVIRIDAE INFECTIONS2
HERPES SIMPLEX2
HERPES ZOSTER2
HETEROCYCLIC COMPOUNDS2
HEXOSES2
HIDRADENITIS2
HIP FRACTURES2
HISTAMINE ANTAGONISTS2
HISTAMINE H1 ANTAGONISTS2
HISTIOCYTOMA, BENIGN FIBROUS2
HISTIOCYTOSIS, LANGERHANS-CELL2
HISTIOCYTOSIS, NON-LANGERHANS-CELL2
HIV ENVELOPE PROTEIN GP1202
HIV INFECTIONS2
HOMOCYSTEINE2
HORMONES2
HORMONE ANTAGONISTS2
HORMONE REPLACEMENT THERAPY2
HOT FLASHES2
HTLV-I INFECTIONS2
HUMIDITY2
HYDANTOINS2
HYDRAZINES2
HYDROCARBONS2
HYDROCARBONS, AROMATIC2
HYDROCARBONS, BROMINATED2
HYDROCARBONS, CHLORINATED2
HYDROCARBONS, FLUORINATED2
HYDROCEPHALUS2
HYDROCHLOROTHIAZIDE2
HYDROCORTISONE2
HYDROFLUORIC ACID2
HYDROXIDES2
HYDROXYBENZOIC ACIDS2
HYDROXYBUTYRATES2
HYDROXYCHOLECALCIFEROLS2
HYPERALDOSTERONISM2
HYPEREMESIS GRAVIDARUM2
HYPEREOSINOPHILIC SYNDROME2
HYPERGLYCEMIA2
HYPERICUM2
HYPERINSULINISM2
HYPERLIPIDEMIA2
HYPERLIPOPROTEINEMIA2
HYPEROXALURIA2
HYPERPARATHYROIDISM2
HYPERPARATHYROIDISM, SECONDARY2
HYPERPHAGIA2
HYPERPROLACTINEMIA2
HYPERSENSITIVITY2
HYPERSENSITIVITY, IMMEDIATE2
HYPERTENSION2
HYPERTENSION, PORTAL2
HYPERTENSION, PULMONARY2
HYPERTENSION, RENAL2
HYPERTHYROIDISM2
HYPERTRIGLYCERIDEMIA2
HYPERURICEMIA2
HYPOGLYCEMIA2
HYPOGLYCEMIC AGENTS2
HYPOGONADISM2
HYPOLIPOPROTEINEMIA2
HYPOPARATHYROIDISM2
HYPOPHOSPHATEMIA2
HYPOPITUITARISM2
HYPOPROTEINEMIA2
HYPOTENSION2
HYPOTHALAMIC DISEASES2
HYPOTHALAMIC NEOPLASMS2
HYPOTHYROIDISM2
HYPOVOLEMIA2
HYPOXIA-ISCHEMIA, BRAIN2
HYSTERECTOMY2
IMIDAZOLES2
IMMERSION2
IMMOBILIZATION2
IMMUNE SYSTEM DISEASES2
IMMUNIZATION2
IMMUNIZATION, PASSIVE2
IMMUNOGLOBULINS2
IMMUNOGLOBULIN FAB FRAGMENTS2
IMMUNOGLOBULIN G2
IMMUNOLOGIC DEFICIENCY SYNDROMES2
IMMUNOSUPPRESSION2
IMMUNOSUPPRESSIVE AGENTS2
IMMUNOTHERAPY, ACTIVE2
IMMUNOTOXINS2
INDANS2
INDAZOLES2
INDOLES2
INDOMETHACIN2
INFANT FOOD2
INFANT NUTRITION DISORDERS2
INFARCTION2
INFECTION2
INFERTILITY2
INFLAMMATION2
INFLAMMATORY BOWEL DISEASES2
INFRATENTORIAL NEOPLASMS2
INSULIN2
INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS2
INTERFERON-ALPHA2
INTERFERONS2
INTERFERON TYPE I2
INTERFERON TYPE I, RECOMBINANT2
INTERFERON TYPE II2
INTERLEUKINS2
INTESTINAL DISEASES2
INTESTINAL DISEASES, PARASITIC2
INTESTINAL NEOPLASMS2
INTESTINAL OBSTRUCTION2
INTESTINAL POLYPOSIS2
INTESTINAL POLYPS2
INTRACRANIAL ARTERIAL DISEASES2
INTRACRANIAL ARTERIOSCLEROSIS2
INTRACRANIAL EMBOLISM AND THROMBOSIS2
INTRACRANIAL HEMORRHAGE, TRAUMATIC2
INTRACRANIAL HEMORRHAGES2
INTRACRANIAL HYPERTENSION2
INTRAUTERINE DEVICES2
IODIDES2
IODINE COMPOUNDS2
IRON COMPOUNDS2
IRON METABOLISM DISORDERS2
IRON OVERLOAD2
ISCHEMIA2
ISOFLAVONES2
ISOQUINOLINES2
ISOTHIOCYANATES2
ISOXAZOLES2
JOINT DISEASES2
JOINT PROSTHESIS2
KERATITIS2
KERATOSIS2
KETONES2
KIDNEY DISEASES2
KIDNEY DISEASES, CYSTIC2
KIDNEY FAILURE2
KIDNEY FAILURE, ACUTE2
KIDNEY NEOPLASMS2
KIDNEY TRANSPLANTATION2
LACTONES2
LAPAROSCOPY2
LARYNGEAL DISEASES2
LARYNGITIS2
LASER SURGERY2
LEAD POISONING2
LECITHIN ACYLTRANSFERASE DEFICIENCY2
LECTINS2
LEGIONELLOSIS2
LEG INJURIES2
LEG ULCER2
LEIOMYOMA2
LEISHMANIASIS2
LENS DISEASES2
LENTIGO2
LEPTIN2
LEPTOSPIROSIS2
LEUKEMIA2
LEUKEMIA, B-CELL2
LEUKEMIA, LYMPHOCYTIC, ACUTE2
LEUKEMIA, LYMPHOCYTIC, CHRONIC2
LEUKEMIA, MYELOID2
LEUKEMIA, MYELOID, CHRONIC2
LEUKEMIA, NONLYMPHOCYTIC, ACUTE2
LEUKEMIA, T-CELL2
LEUKEMIA, T-CELL, ACUTE2
LEUKOARAIOSIS2
LEUKOCYTE DISORDERS2
LEUKOCYTOSIS2
LI-FRAUMENI SYNDROME2
LICHENOID ERUPTIONS2
LICHEN PLANUS2
LIDOCAINE2
LIGHT2
LINOLEIC ACIDS2
LIPIDS2
LIPID METABOLISM, INBORN ERRORS2
LIPODYSTROPHY2
LIPOPOLYSACCHARIDES2
LIPOPROTEINS2
LIPOPROTEIN LIPASE DEFICIENCY, FAMILIAL2
LITHIUM2
LITHIUM COMPOUNDS2
LITHOTRIPSY2
LIVER CIRRHOSIS2
LIVER DISEASES2
LIVER DISEASES, PARASITIC2
LIVER FAILURE2
LIVER NEOPLASMS2
LUNG DISEASES2
LUNG DISEASES, INTERSTITIAL2
LUNG DISEASES, OBSTRUCTIVE2
LUNG DISEASES, PARASITIC2
LUNG NEOPLASMS2
LUNG TRANSPLANTATION2
LUPUS ERYTHEMATOSUS, DISCOID2
LUPUS ERYTHEMATOSUS, SYSTEMIC2
LUTEINIZING HORMONE2
LYME DISEASE2
LYMPHADENITIS2
LYMPHANGIECTASIS2
LYMPHATIC DISEASES2
LYMPHEDEMA2
LYMPHOKINES2
LYMPHOMA2
LYMPHOMA, B-CELL2
LYMPHOMA, LARGE-CELL2
LYMPHOMA, LOW-GRADE2
LYMPHOMA, NON-HODGKIN2
LYMPHOMA, SMALL CLEAVED-CELL, DIFFUSE2
LYMPHOMA, T-CELL2
LYMPHOPENIA2
LYMPHOPROLIFERATIVE DISORDERS2
LYMPH NODE EXCISION2
LYSOPHOSPHOLIPIDS2
LYSOSOMAL STORAGE DISEASES2
MACROLIDES2
MAGNESIUM COMPOUNDS2
MAGNESIUM SILICATES2
MAGNETICS2
MAGNETIC RESONANCE IMAGING2
MAGNETIC RESONANCE SPECTROSCOPY2
MALABSORPTION SYNDROMES2
MALACOPLAKIA2
MALARIA2
MALARIA, FALCIPARUM2
MALIGNANT CARCINOID SYNDROME2
MALNUTRITION2
MAMMAPLASTY2
MANIPULATION, SPINAL2
MARINE TOXINS2
MASSAGE2
MASTECTOMY2
MEAT2
MEDIASTINAL DISEASES2
MEDICAL ERRORS2
MEDROXYPROGESTERONE2
MEGACOLON2
MEGESTROL2
MEGLUMINE2
MELANOMA2
MELANOSIS2
MEMBRANE GLYCOPROTEINS2
MEMORY DISORDERS2
MENINGEAL NEOPLASMS2
MENINGITIS2
MENINGITIS, BACTERIAL2
MENINGITIS, FUNGAL2
MENINGITIS, VIRAL2
MENINGOCOCCAL INFECTIONS2
MENSTRUATION DISTURBANCES2
MENTAL DISORDERS2
MENTAL RETARDATION2
MEPERIDINE2
MERCURY POISONING2
MERCURY POISONING, NERVOUS SYSTEM2
METABOLIC DISEASES2
METABOLISM, INBORN ERRORS2
METALS2
METALS, HEAVY2
METALS, LIGHT2
METALS, RARE EARTH2
METAPLASIA2
METHADONE2
METHIONINE2
METHYLMERCURY COMPOUNDS2
METHYLMETHACRYLATES2
METHYLNITRONITROSOGUANIDINE2
METHYLPREDNISOLONE2
METHYL ETHERS2
MIGRAINE DISORDERS2
MILK2
MILK PROTEINS2
MINERALS2
MIOSIS2
MITOCHONDRIAL DISEASES2
MITOCHONDRIAL ENCEPHALOMYOPATHIES2
MITOGENS2
MITRAL VALVE PROLAPSE2
MONOTERPENES2
MOOD DISORDERS2
MORPHINANS2
MOTION SICKNESS2
MOTOR NEURON DISEASE2
MOUTH, EDENTULOUS2
MOUTH DISEASES2
MOUTH NEOPLASMS2
MOVEMENT DISORDERS2
MUCINOSES2
MUCOPOLYSACCHARIDOSES2
MULTIPLE ENDOCRINE NEOPLASIA2
MULTIPLE SCLEROSIS2
MUMPS VACCINE2
MUSCULAR ATROPHY, SPINAL2
MUSCULAR DISEASES2
MUSCULAR DISORDERS, ATROPHIC2
MUSCULAR DYSTROPHIES2
MUSCULOSKELETAL ABNORMALITIES2
MUSCULOSKELETAL DISEASES2
MUSCULOSKELETAL MANIPULATIONS2
MUSTARD COMPOUNDS2
MUTAGENS2
MYASTHENIA GRAVIS2
MYCOPLASMA INFECTIONS2
MYCOSES2
MYCOTOXICOSIS2
MYCOTOXINS2
MYDRIATICS2
MYELITIS2
MYELODYSPLASTIC SYNDROMES2
MYELOGRAPHY2
MYELOPROLIFERATIVE DISORDERS2
MYOCARDIAL INFARCTION2
MYOCARDIAL ISCHEMIA2
MYOCARDIAL REVASCULARIZATION2
MYOCLONIC EPILEPSIES, PROGRESSIVE2
MYOSITIS2
MYOTONIC DISORDERS2
NAIL DISEASES2
NAPHTHALENES2
NAPHTHALENESULFONATES2
NAPROXEN2
NECK INJURIES2
NEISSERIACEAE INFECTIONS2
NEOPLASMS2
NEOPLASMS, ADIPOSE TISSUE2
NEOPLASMS, CONNECTIVE TISSUE2
NEOPLASMS, GERM CELL AND EMBRYONAL2
NEOPLASMS, MULTIPLE PRIMARY2
NEOPLASMS, MUSCLE TISSUE2
NEOPLASMS, NEUROEPITHELIAL2
NEOPLASMS, UNKNOWN PRIMARY2
NEOPLASMS, VASCULAR TISSUE2
NEOVASCULARIZATION, PATHOLOGIC2
NEPHRITIS2
NEPHRITIS, INTERSTITIAL2
NEPHROSIS2
NERVE BLOCK2
NERVE COMPRESSION SYNDROMES2
NERVE DEGENERATION2
NERVE GROWTH FACTORS2
NERVE SHEATH NEOPLASMS2
NERVOUS SYSTEM DISEASES2
NERVOUS SYSTEM MALFORMATIONS2
NEURAL TUBE DEFECTS2
NEURILEMMOMA2
NEUROBLASTOMA2
NEUROCUTANEOUS SYNDROMES2
NEURODEGENERATIVE DISEASES2
NEUROFIBROMATOSES2
NEUROMA2
NEUROMA, ACOUSTIC2
NEUROMUSCULAR BLOCKING AGENTS2
NEUROMUSCULAR DISEASES2
NEUROPEPTIDES2
NEUROSYPHILIS2
NEUROTOXICITY SYNDROMES2
NEUROTOXINS2
NEUROTRANSMITTER AGENTS2
NEUROTRANSMITTER UPTAKE INHIBITORS2
NICOTINIC ACIDS2
NICOTINIC AGONISTS2
NITRATES2
NITRILES2
NITRITES2
NITROGEN COMPOUNDS2
NITROGEN MUSTARD COMPOUNDS2
NITROGEN OXIDES2
NITROIMIDAZOLES2
NITROSAMINES2
NITROSOUREA COMPOUNDS2
NITROSO COMPOUNDS2
NITROUS ACID2
NITRO COMPOUNDS2
NOISE2
NORGESTREL2
NORPREGNENES2
NUCLEIC ACID SYNTHESIS INHIBITORS2
NUTRITION DISORDERS2
NYSTAGMUS, PATHOLOGIC2
OBESITY2
OBSTETRIC SURGICAL PROCEDURES2
OCULOMOTOR NERVE DISEASES2
ODONTOGENIC CYSTS2
OILS2
OKADAIC ACID2
OLEIC ACIDS2
OLIGOHYDRAMNIOS2
OLIGOPEPTIDES2
OMEPRAZOLE2
OPHTHALMOPLEGIA2
OPHTHALMOPLEGIA, CHRONIC PROGRESSIVE EXTERNAL2
OPIOID-RELATED DISORDERS2
OPPORTUNISTIC INFECTIONS2
OPTIC NERVE DISEASES2
ORGANIC CHEMICALS2
ORGANOMETALLIC COMPOUNDS2
ORGANOPHOSPHORUS COMPOUNDS2
ORGANOPLATINUM COMPOUNDS2
ORGANOTHIOPHOSPHORUS COMPOUNDS2
ORTHOMYXOVIRIDAE INFECTIONS2
ORTHOPEDIC FIXATION DEVICES2
ORTHOPEDIC PROCEDURES2
OSSIFICATION, HETEROTOPIC2
OSTEOARTHRITIS2
OSTEOCHONDRITIS2
OSTEOCHONDRODYSPLASIAS2
OSTEOCHONDROMATOSIS2
OSTEOPOROSIS2
OSTEOSARCOMA2
OSTEOTOMY2
OSTOMY2
OTITIS MEDIA2
OUABAIN2
OVARIAN CYSTS2
OVARIAN DISEASES2
OVARIAN NEOPLASMS2
OXAZINES2
OXIDANTS2
OXIDES2
OXIDOPAMINE2
OXIMES2
OXYGEN2
OXYGENATORS2
OXYTOCIN2
PAIN2
PALMITIC ACIDS2
PANAX2
PANCREATIC CYST2
PANCREATIC DISEASES2
PANCREATIC ELASTASE2
PANCREATIC NEOPLASMS2
PANCREATITIS2
PAPILLOMA2
PAPILLOMAVIRUS INFECTIONS2
PAPOVAVIRIDAE INFECTIONS2
PARACENTESIS2
PARAGANGLIOMA2
PARAGANGLIOMA, EXTRA-ADRENAL2
PARANASAL SINUS NEOPLASMS2
PARANEOPLASTIC ENDOCRINE SYNDROMES2
PARANEOPLASTIC SYNDROMES2
PARAPLEGIA2
PARAPROTEINEMIAS2
PARASYMPATHOLYTICS2
PARASYMPATHOMIMETICS2
PARATHYROIDECTOMY2
PARATHYROID DISEASES2
PARENTERAL NUTRITION2
PARKINSONIAN DISORDERS2
PARKINSON DISEASE, SECONDARY2
PAROTITIS2
PARTIAL THROMBOPLASTIN TIME2
PARVOVIRIDAE INFECTIONS2
PELVIC INFLAMMATORY DISEASE2
PENILE DISEASES2
PENTANOIC ACIDS2
PEPTIC ULCER2
PEPTIDES2
PEPTIDES, CYCLIC2
PERFUSION2
PERICARDITIS2
PERIODONTAL DISEASES2
PERIODONTITIS2
PERIOPERATIVE CARE2
PERIPHERAL NERVOUS SYSTEM DISEASES2
PERITONEAL DIALYSIS2
PERITONEAL DISEASES2
PERITONITIS2
PEROXIDES2
PERTUSSIS VACCINE2
PESTICIDES2
PETROLATUM2
PETROLEUM2
PHARMACEUTICAL PREPARATIONS2
PHARMACEUTICAL SOLUTIONS2
PHARMACEUTIC AIDS2
PHARYNGEAL DISEASES2
PHENACETIN2
PHENANTHRENES2
PHENETHYLAMINES2
PHENOBARBITAL2
PHENOLPHTHALEINS2
PHENOLS2
PHENOTHIAZINES2
PHENYLACETATES2
PHENYLKETONURIAS2
PHENYLPROPANOLAMINE2
PHENYLPROPIONATES2
PHENYLUREA COMPOUNDS2
PHENYL ETHERS2
PHLEBITIS2
PHOSPHATIDYLCHOLINES2
PHOSPHATIDYLGLYCEROLS2
PHOSPHORUS COMPOUNDS2
PHOSPHORUS METABOLISM DISORDERS2
PHOTOCHEMOTHERAPY2
PHOTOSENSITIVITY DISORDERS2
PHTHALIMIDES2
PHYSICAL STIMULATION2
PHYSICAL THERAPY MODALITIES2
PHYTOTHERAPY2
PICORNAVIRIDAE INFECTIONS2
PIGMENTATION DISORDERS2
PIPECOLIC ACIDS2
PIPERAZINES2
PIPERIDINES2
PIPERIDONES2
PIPERONYL BUTOXIDE2
PITUITARY DISEASES2
PITUITARY FUNCTION TESTS2
PITUITARY NEOPLASMS2
PITYRIASIS RUBRA PILARIS2
PLACENTAL LACTOGEN2
PLACENTA DISEASES2
PLANTS2
PLANTS, EDIBLE2
PLANT COMPONENTS, AERIAL2
PLANT EXTRACTS2
PLANT LECTINS2
PLANT OILS2
PLANT POISONING2
PLANT PREPARATIONS2
PLASMACYTOMA2
PLASMIN2
PLASMINOGEN ACTIVATORS2
PLATELET AGGREGATION INHIBITORS2
PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX2
PLATINUM COMPOUNDS2
PLEURAL EFFUSION2
PNEUMOCOCCAL INFECTIONS2
PNEUMOCONIOSIS2
PNEUMONIA2
PNEUMONIA, BACTERIAL2
PNEUMOPERITONEUM, ARTIFICIAL2
PODOPHYLLOTOXIN2
POLIOMYELITIS2
POLIOVIRUS VACCINES2
POLYCHLORINATED BIPHENYLS2
POLYCYCLIC COMPOUNDS2
POLYCYCLIC HYDROCARBONS, AROMATIC2
POLYCYSTIC KIDNEY DISEASES2
POLYETHYLENE GLYCOLS2
POLYMERS2
POLYMETHACRYLIC ACIDS2
POLYMYOSITIS2
POLYNEUROPATHIES2
POLYPS2
POLYRADICULONEUROPATHY2
POLYSACCHARIDES2
POLYSACCHARIDES, BACTERIAL2
POLYTETRAFLUOROETHYLENE2
POLYVINYLS2
PORPHYRIAS2
PORPHYRIAS, HEPATIC2
PORPHYRINS2
POTASSIUM COMPOUNDS2
PRAZOSIN2
PRE-ECLAMPSIA2
PRECANCEROUS CONDITIONS2
PREDIABETIC STATE2
PREDNISOLONE2
PREDNISONE2
PREGNADIENES2
PREGNANCY, ECTOPIC2
PREGNANCY IN DIABETICS2
PREGNENEDIONES2
PREIMPLANTATION DIAGNOSIS2
PREMEDICATION2
PRENATAL DIAGNOSIS2
PRESERVATION, BIOLOGICAL2
PRESSURE2
PROCAINE2
PROGESTERONE2
PROGESTERONE CONGENERS2
PROPANOLAMINES2
PROPIONIC ACIDS2
PROPIOPHENONES2
PROPYLAMINES2
PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES2
PROSTAGLANDINS E2
PROSTAGLANDINS E, SYNTHETIC2
PROSTAGLANDINS F, SYNTHETIC2
PROSTATECTOMY2
PROSTATIC DISEASES2
PROSTHESES AND IMPLANTS2
PROSTHESIS IMPLANTATION2
PROTEASE INHIBITORS2
PROTECTIVE CLOTHING2
PROTECTIVE DEVICES2
PROTEIN-ENERGY MALNUTRITION2
PROTEINS2
PROTEINURIA2
PROTEIN PRECURSORS2
PROTOZOAN INFECTIONS, ANIMAL2
PSEUDOHERMAPHRODITISM2
PSORALENS2
PSORIASIS2
PSYCHOPHYSIOLOGIC DISORDERS2
PSYCHOTIC DISORDERS2
PSYCHOTROPIC DRUGS2
PTERIDIUM2
PUERPERAL DISORDERS2
PULMONARY DISEASE, CHRONIC OBSTRUCTIVE2
PULMONARY EMPHYSEMA2
PUNCTURES2
PURINES2
PURPURA2
PURPURA, THROMBOCYTOPENIC2
PUVA THERAPY2
PYELONEPHRITIS2
PYODERMA2
PYRAZINES2
PYRAZOLES2
PYRENES2
PYRETHRINS2
PYRIDAZINES2
PYRIDINES2
PYRIDINIUM COMPOUNDS2
PYRIDONES2
PYRIMIDINES2
PYRIMIDINONES2
PYRROLES2
PYRROLIDINES2
PYRUVATE METABOLISM, INBORN ERRORS2
QUATERNARY AMMONIUM COMPOUNDS2
QUERCETIN2
QUINOLINES2
QUINOLINIC ACID2
QUINOLONES2
QUINOXALINES2
RADIATION, NONIONIZING2
RADIATION-PROTECTIVE AGENTS2
RADIATION-SENSITIZING AGENTS2
RADIATION INJURIES2
RADIOACTIVE POLLUTANTS2
RADIOGRAPHY2
RADIOTHERAPY2
RADIO WAVES2
RADIUS FRACTURES2
RADON2
RAYNAUD DISEASE2
REACTIVE NITROGEN SPECIES2
REACTIVE OXYGEN SPECIES2
RECOMBINANT PROTEINS2
RECTAL FISTULA2
RED-CELL APLASIA, PURE2
RENAL AGENTS2
RENAL DIALYSIS2
RENAL REPLACEMENT THERAPY2
RENAL TUBULAR TRANSPORT, INBORN ERRORS2
REOVIRIDAE INFECTIONS2
REPERFUSION2
REPERFUSION INJURY2
REPLANTATION2
RESINS, SYNTHETIC2
RESORCINOLS2
RESPIRATION DISORDERS2
RESPIRATORY DISTRESS SYNDROME, NEWBORN2
RESPIRATORY FUNCTION TESTS2
RESPIRATORY HYPERSENSITIVITY2
RESPIRATORY INSUFFICIENCY2
RESPIRATORY SYSTEM ABNORMALITIES2
RESPIRATORY SYSTEM AGENTS2
RESPIRATORY THERAPY2
RESPIRATORY TRACT INFECTIONS2
RESTRAINT, PHYSICAL2
RESUSCITATION2
RETINAL DISEASES2
RETINITIS PIGMENTOSA2
RETINOIDS2
RHEUMATIC DISEASES2
RHEUMATIC FEVER2
RHINITIS2
RIBONUCLEOSIDES2
RICKETS2
ROTATION2
ROTHMUND-THOMSON SYNDROME2
RUBBER2
RUBELLA2
RUBELLA VACCINE2
RUBULAVIRUS INFECTIONS2
SALICYLIC ACIDS2
SALIVARY GLAND NEOPLASMS2
SALMONELLA INFECTIONS2
SARCOIDOSIS2
SARCOMA2
SCALP DERMATOSES2
SCHISTOSOMIASIS2
SCHIZOPHRENIA2
SCLERODERMA, LIMITED2
SCLERODERMA, SYSTEMIC2
SEAFOOD2
SEIZURES2
SELF-INJURIOUS BEHAVIOR2
SEPSIS2
SEPSIS SYNDROME2
SEROTONIN AGENTS2
SERTRALINE2
SERUM ALBUMIN2
SEXUALLY TRANSMITTED DISEASES2
SEXUALLY TRANSMITTED DISEASES, BACTERIAL2
SEXUAL DYSFUNCTION, PHYSIOLOGICAL2
SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL2
SHOCK2
SIALIC ACIDS2
SIGMOID DISEASES2
SILICON2
SILICONES2
SILICON DIOXIDE2
SILICOSIS2
SINUSITIS2
SINUS THROMBOSIS, INTRACRANIAL2
SITUS INVERSUS2
SKIN DISEASES2
SKIN DISEASES, BACTERIAL2
SKIN DISEASES, VASCULAR2
SKIN DISEASES, VIRAL2
SKIN ULCER2
SKULL FRACTURES2
SKULL NEOPLASMS2
SLEEP APNEA, OBSTRUCTIVE2
SLEEP APNEA SYNDROMES2
SLEEP DISORDERS2
SLEEP INITIATION AND MAINTENANCE DISORDERS2
SMOKE2
SMOKING2
SNORING2
SODIUM2
SODIUM, DIETARY2
SODIUM CHLORIDE2
SODIUM CHLORIDE SYMPORTER INHIBITORS2
SODIUM COMPOUNDS2
SOFT TISSUE NEOPLASMS2
SOIL POLLUTANTS2
SOLANACEOUS ALKALOIDS2
SOLUTIONS2
SOLVENTS2
SOMATOFORM DISORDERS2
SOMATOMEDINS2
SOYBEANS2
SPECIMEN HANDLING2
SPINAL CORD DISEASES2
SPINAL CORD INJURIES2
SPINAL CURVATURES2
SPINAL DISEASES2
SPINAL DYSRAPHISM2
SPINAL INJURIES2
SPINAL OSTEOPHYTOSIS2
SPINOCEREBELLAR ATAXIAS2
SPLENIC RUPTURE2
SPONDYLARTHROPATHIES2
SPONDYLITIS2
SPRAINS AND STRAINS2
STAPHYLOCOCCAL INFECTIONS2
STATUS EPILEPTICUS2
STEARIC ACIDS2
STEREOTAXIC TECHNIQUES2
STERILIZATION, REPRODUCTIVE2
STEROIDS2
STEROID METABOLISM, INBORN ERRORS2
STEROLS2
STILBENES2
STOMACH DISEASES2
STREET DRUGS2
STREPTOCOCCAL INFECTIONS2
STRESS2
STRESS, PSYCHOLOGICAL2
STRESS DISORDERS, POST-TRAUMATIC2
STRONGYLOIDIASIS2
STYRENE2
SUBARACHNOID HEMORRHAGE2
SUBSTANCE-RELATED DISORDERS2
SUBSTANCE WITHDRAWAL SYNDROME2
SUCROSE2
SUGAR ACIDS2
SULFATES2
SULFONAMIDES2
SULFONES2
SULFONYLUREA COMPOUNDS2
SULFUR COMPOUNDS2
SULFUR OXIDES2
SUNLIGHT2
SUPPURATION2
SYMPATHOMIMETICS2
SYNCOPE2
SYNDACTYLY2
SYNOVIAL CYST2
SYPHILIS2
TACHYCARDIA2
TACHYCARDIA, SUPRAVENTRICULAR2
TACRINE2
TAMOXIFEN2
TANNINS2
TARS2
TAURINE2
TAXOIDS2
TELANGIECTASIS2
TELLURIUM2
TERATOGENS2
TERPENES2
TESTICULAR DISEASES2
TESTICULAR NEOPLASMS2
TESTOSTERONE2
TESTOSTERONE CONGENERS2
TETANUS TOXOID2
TETRAZOLES2
THALASSEMIA2
THIAMINE DEFICIENCY2
THIAZEPINES2
THIAZINES2
THIAZOLES2
THINNESS2
THIOCARBAMATES2
THIOPHENES2
THORACIC INJURIES2
THORACIC NEOPLASMS2
THORACIC OUTLET SYNDROME2
THORACIC SURGICAL PROCEDURES2
THROMBOCYTOPENIA2
THROMBOCYTOSIS2
THROMBOEMBOLISM2
THROMBOLYTIC THERAPY2
THROMBOPHILIA2
THROMBOSIS2
THYROIDECTOMY2
THYROIDITIS2
THYROID DISEASES2
THYROID HORMONES2
THYROID NEOPLASMS2
THYROTOXICOSIS2
THYROTROPIN2
TICK-BORNE DISEASES2
TISSUE ADHESIVES2
TOBACCO2
TOLUENE2
TONSILLITIS2
TOOTH DISEASES2
TOOTH EXTRACTION2
TOXEMIA2
TOXINS, BIOLOGICAL2
TOXOPLASMOSIS2
TRACHEAL DISEASES2
TRANQUILIZING AGENTS2
TRANSITION ELEMENTS2
TRANSPLANTATION2
TRANSPLANTATION, HOMOLOGOUS2
TRIALKYLTIN COMPOUNDS2
TRIAMCINOLONE2
TRIAZINES2
TRIAZOLES2
TRIGEMINAL NERVE DISEASES2
TRIHALOMETHANES2
TRIIODOBENZOIC ACIDS2
TRITERPENES2
TROPANES2
TROPHOBLASTIC NEOPLASMS2
TUBERCULOSIS2
TUBERCULOSIS, CARDIOVASCULAR2
TUBERCULOSIS, CENTRAL NERVOUS SYSTEM2
TUBERCULOSIS, CUTANEOUS2
TUBERCULOSIS, OSTEOARTICULAR2
TUBERCULOSIS, PLEURAL2
TUBERCULOSIS, PULMONARY2
TUBERCULOSIS, UROGENITAL2
TUMOR VIRUS INFECTIONS2
TYRAMINE2
TYROSINE2
ULCER2
ULNA FRACTURES2
ULTRAVIOLET THERAPY2
UNCONSCIOUSNESS2
UREA2
UREMIA2
URETERAL DISEASES2
URETHANE2
URETHRAL OBSTRUCTION2
URETHRITIS2
URINARY CALCULI2
URINARY DIVERSION2
URINARY TRACT INFECTIONS2
URINATION DISORDERS2
UROGENITAL ABNORMALITIES2
UROLOGIC DISEASES2
UROLOGIC NEOPLASMS2
URTICARIA2
UTERINE CERVICAL DISEASES2
UTERINE DISEASES2
UTERINE NEOPLASMS2
UTERINE RUPTURE2
UVEITIS, ANTERIOR2
VACCINES2
VACCINES, COMBINED2
VACCINES, INACTIVATED2
VAGINAL DISEASES2
VAGINITIS2
VALINE2
VANADIUM COMPOUNDS2
VARICOSE VEINS2
VASCULAR DISEASES2
VASCULAR FISTULA2
VASCULITIS2
VASCULITIS, CENTRAL NERVOUS SYSTEM2
VASCULITIS, HYPERSENSITIVITY2
VASOCONSTRICTOR AGENTS2
VASOPRESSINS2
VEGETABLES2
VENOMS2
VENOUS INSUFFICIENCY2
VENOUS THROMBOSIS2
VENTRICULAR DYSFUNCTION2
VERTEBROBASILAR INSUFFICIENCY2
VESTIBULAR DISEASES2
VIBRATION2
VINCA ALKALOIDS2
VINYL COMPOUNDS2
VIPER VENOMS2
VIRAL HEPATITIS VACCINES2
VIRAL VACCINES2
VIRILISM2
VIRUS DISEASES2
VISION DISORDERS2
VITAMIN A2
VITAMIN B 122
VITAMIN B 12 DEFICIENCY2
VITAMIN B DEFICIENCY2
VITAMIN D2
VITAMIN D DEFICIENCY2
VITAMIN K2
VITAMIN K DEFICIENCY2
VOMITING2
WARTS2
WASTE PRODUCTS2
WATER2
WATER-ELECTROLYTE IMBALANCE2
WATER POLLUTANTS2
WATER POLLUTION, CHEMICAL2
WEIGHTLESSNESS SIMULATION2
WHEELCHAIRS2
WILMS TUMOR2
WOUNDS, NONPENETRATING2
WOUNDS, PENETRATING2
WOUNDS, STAB2
WOUNDS AND INJURIES2
X-RAYS2
XANTHINES2
XANTHONES2
XEROSTOMIA2
YOHIMBINE2
ZYGOMYCOSIS2
METABOLOME ASSOCIATIONS: MTHFR
HMDB ID METABOLITE
HMDB01533 5,10-METHYLENE-THF
HMDB01396 5-METHYLTETRAHYDROFOLIC ACID