Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


i5007206

Hard Link
i5007206 is a snp on gene MAT1A (methionine adenosyltransferase I, alpha)

GeneMAT1A Chromosome number Chromosome position
Alleles (transliterated to +) Minor Allele Minor Allele Frequency
Notation rs118204003 1070C>T Pro357Leu Clinical significance Orientation (dbSNP) - (negative/reverse strand)
SNP Function
[PMID: 7560086] mutations partially inactivate MAT activity.
Gene Function
Methionine adenosyltransferase I, alpha (MAT1A gene) provides instructions for producing the enzyme methionine adenosyltransferase. The enzyme is produced from the MAT1A gene in two forms, alpha and beta. The alpha form, called a homotetramer, is made up of four identical protein subunits. The beta form, called a homodimer, is made up of two of the same protein subunits. Both forms of the enzyme are found in the liver. Both the alpha and beta forms of MAT1A help break down a protein building block (amino acid) called methionine. The enzyme starts the reaction that converts methionine to S-adenosylmethionine (AdoMet or SAMe). AdoMet transfers methyl groups (one carbon atom and three hydrogen atoms) to other compounds- a process called transmethylation. Transmethylation is important in many cellular processes. These include determining whether the instructions in a segment of DNA are carried out, regulating reactions involving proteins and lipids, and controlling the processing of chemicals that relay signals in the nervous system (neurotransmitters).
 
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

NOT REPORTED




Ancestry DNA

NOT REPORTED




Genos Export for Promethease

NOT REPORTED




DSL/ Opus Chip

NOT REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





MOST RECENT SEARCHES:
rs36010656 () | rs174556 () | rs9282861 (SULT1A1) | rs1799732 () | i5007206 (MAT1A) | rs2994388 () | rs4933327 () | rs2993763 (MAT1A) | rs7097297 () | rs10509413 () | rs1832683 ()

MOST FREQUENTLY SEARCHED:
rs429358 (APOE) | rs9939609 (FTO) | rs1799941 (SHBG) | rs1801133 (MTHFR) | rs1801181 (CBS) | rs4680 (COMT) | rs6025 (F5) | rs20541 (IL13) | rs2569191 (CD14) | rs2235544 (DIO1) | rs2187668 (HLA-DQA1)








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