Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs10046

Hard Link
rs10046 is a snp on gene CYP19A1 (cytochrome P450, family 19, subfamily A, polypeptide 1)

GeneCYP19A1 Chromosome number Chromosome position
Alleles (transliterated to +) Minor Allele Minor Allele Frequency
Notation *19C>T Clinical significance Orientation (dbSNP) - (negative/reverse strand)
SNP Function
3' UTR variant in exon 10
Gene Function
CYP19A1 (also known as 'aromatase') catalyzes the last steps of in the synthesis of estrogen. Polymorphisms in this gene can result in either increased or decreased aromatase activity.  Aromatase activates many reactions involved in the production of steroids.  In particular, aromatase is responsible for the aromatization of androgens (testosterone, DHEA, DHT) into estrogens. The aromatase enzyme can be found in many tissues including gonads, brain, adipose tissue, placenta, blood vessels, skin, and bone, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer.  It is an important factor in sexual development. CYP450 family member plays a much greater role in the regulation of oxidative stress due to its redox effects. When upregulated it is a major contributor of ROS and major consumer of reducing agent NADPH, important in glutathione recycling. CYP450 family also play a major role in cell danger signaling and cell turnover as it interacts electrically with the apoptosis mechanisms controlled by mitochondria.
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

NOT REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

NOT REPORTED




DSL/ Opus Chip

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





MOST RECENT SEARCHES:
rs34116584 (AGXT) | rs41307258 (TBX22) | rs6993813 () | rs1495741 (NAT2) | rs10046 (CYP19A1) | rs1801198 (TCN2) | rs17036170 (PPARG) | rs2908004 () | Rs17036170 (PPARG) | Rs3856806 (PPARG) | rs2707466 (WNT16)

MOST FREQUENTLY SEARCHED:
rs429358 (APOE) | rs9939609 (FTO) | rs1799941 (SHBG) | rs1801133 (MTHFR) | rs1801181 (CBS) | rs4680 (COMT) | rs6025 (F5) | rs20541 (IL13) | rs2569191 (CD14) | rs2235544 (DIO1) | rs2187668 (HLA-DQA1)








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