Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs1019385

Hard Link
rs1019385 is a snp on gene GRIN2B (glutamate receptor, ionotropic, N-methyl D-aspartate 2B)

GeneGRIN2B Chromosome number 12 Chromosome position 13981909
Alleles C/A (transliterated to +) Minor Allele A Minor Allele Frequency 0.4287
Notation Clinical significance Orientation (dbSNP) - (negative/reverse strand)
Gene Function
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. Variations in the GRIN2B gene have been associated with bipolar disorder, schizophrenia, Alzheimer’s disease (AD) and obsessive–compulsive disorder. Both linkage and association studies showed that GRIN2B might play a role in schizophrenia and bipolar disorder in Ashkenazi Jewish population samples. In addition, the NMDA protein encoded by the GRIN2B gene is involved in learning and memory and is a therapeutic target in AD.  
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

NOT REPORTED




Opus 23 Curated

NOT CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





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