Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs10857796

Hard Link
rs10857796 is a snp on gene GSTM1 (glutathione S-transferase mu 1)

GeneGSTM1 Chromosome number 1 Chromosome position 109692410
Alleles A/G Minor Allele A Minor Allele Frequency 0.0835
Notation Clinical significance Orientation (dbSNP) + (positive/forward strand)
Gene Function
GSTM1 encodes an enzyme that functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. This classof enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. 'Null' mutations in GSTM1 have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. Research studies have indicated that people who have a GSTM1 "null genotype" might gain more benefit for preventing cancers from eating broccoli and cruciferous vegetables than those who lack this gene. This may be particularly relevant as a dietary intervention in families that carry increased genetic risk for prostate cancer.
This SNP is reported by one or more services.


23andme V3

NOT REPORTED




23andme V4

REPORTED




23andme V5

NOT REPORTED




Ancestry DNA

NOT REPORTED




Genos Export for Promethease

NOT REPORTED




Opus 23 Curated

NOT CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





MOST RECENT SEARCHES:
rs75472618 (PLCG2) | rs187956469 (PLCG2) | rs36049418 (SLC12A3) | rs2687116 (CYP3A4) | rs140310 (GSTT1) | rs10857796 (GSTM1) | rs123 (OSBPL3) | rs806368 (CNR1) | rs9290264 (LOC105374192) | rs1019385 (GRIN2B) | rs2522129 (SIRT4)

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rs1799941 (SHBG) | rs1801133 (MTHFR) | rs9939609 (FTO) | rs1801181 (CBS) | rs4680 (COMT) | rs6025 (F5) | rs2075252 (LRP2) | rs2569191 (CD14) | rs20541 (IL13) | rs2235544 (DIO1) | rs2844682 ()








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